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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Lipase, gastric

gastric lipase, gastric lipase,
This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, AGE, fibrillin-1
Papers on gastric lipase
Yarrowia lipolytica Lipase 2 Is Stable and Highly Active in Test Meals and Increases Fat Absorption in an Animal Model of Pancreatic Exocrine Insufficiency.
Carrière et al., Marseille, France. In Gastroenterology, Dec 2015
YLLIP2 or other gastric (LIPF) and pancreatic (PNLIPD) lipases were added to a meal paste containing dietary triglycerides, at a range of pH values (pH 2-7), with and without pepsin or human bile and incubated at 37°C.
Impact of gastrointestinal lipolysis on oral lipid-based formulations and bioavailability of lipophilic drugs.
Carrière, Marseille, France. In Biochimie, Dec 2015
Lipolysis however starts within the stomach through the action of gastric lipase, the first enzyme involved in fat digestion in humans.
Relevant pH and lipase for in vitro models of gastric digestion.
Carrière et al., Marseille, France. In Food Funct, Dec 2015
In vivo data on gastric lipase and lipolysis have however been collected in humans and dogs during test meals.
New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression.
Roxo-Rosa et al., Rio de Mouro, Portugal. In World J Gastroenterol, Jul 2015
Entailing good gastric properties, both NCI-hTERT-clones were found to produce pepsinogen-5 and human gastric lipase.
Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase.
Carrière et al., Marseille, France. In Pharm Res, Apr 2015
Here, the impact of gastric lipase on the digestion of representative formulations from the Lipid Formulation Classification System has been investigated.
Selective factors governing in vitro β-carotene bioaccessibility: negative influence of low filtration cutoffs and alterations by emulsifiers and food matrices.
Bohn et al., Luxembourg. In Nutr Res, 2014
lecithin and taurocholate), (iii) addition of a gastric lipase, and (iv) final filtration (20 or 200 nm) of the digesta.
In vitro digestion of citric acid esters of mono- and diglycerides (CITREM) and CITREM-containing infant formula/emulsions.
Carrière et al., Marseille, France. In Food Funct, 2014
It was shown here that fatty acids are released from CITREM by gastric lipase, pancreatic lipase, pancreatic-lipase-related protein 2 and carboxyl ester hydrolase.
A standardised static in vitro digestion method suitable for food - an international consensus.
Brodkorb et al., Zeist, Netherlands. In Food Funct, 2014
Other parameters such as the presence of phospholipids, individual enzymes such as gastric lipase and digestive emulsifiers vs. their mixtures (e.g.
Investigation of novel chemical inhibitors of human lysosomal acid lipase: virtual screening and molecular docking studies.
Tahir et al., Islamabad, Pakistan. In Comb Chem High Throughput Screen, 2013
Specifically for this study a homology model of LipA enzyme was generated based on the structure of dog gastric lipase.
Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Goñi et al., Mumbai, India. In F1000res, 2012
A pancreatic lipase and a gastric lipase are among the proteins that are identified as proteins having promiscuous SPASE scaffolds that could interact with DPP4 inhibitors.
Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system.
Lomonossoff et al., Norwich, United Kingdom. In Protein Expr Purif, 2012
Recombinant human gastric lipase (hGL) was transiently expressed in Nicotiana benthamiana leaves using the CPMV-HT expression system.
Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems.
Carrière et al., Marseille, France. In Ther Deliv, 2012
It was established, however, that gastric lipase, pancreatic carboxyl ester hydrolaze and pancreatic lipase-related protein 2 are the major players involved in the lipolysis of lipid excipients containing acylglycerols and polyethyleneglycol esters.
Molecular dynamics simulations of human and dog gastric lipases: insights into domain movements.
Pennathur et al., Chennai, India. In Febs Lett, 2010
insights into the domain movements
Lipid digestion and absorption in early life: an update.
Hernell et al., Umeå, Sweden. In Curr Opin Clin Nutr Metab Care, 2010
Instead the PTL-related protein 2 and bile salt-stimulated lipase (BSSL) are the key enzymes secreted from pancreas, which in concerted action with gastric lipase operate to achieve efficient fat absorption during infancy.
An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer.
Yang et al., Seoul, South Korea. In Int J Oncol, 2010
down-regulated KLF4, CHGA, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA is an 8-gene signature for gastric cancer
The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.
Thummel et al., Salt Lake City, United States. In Cell Metab, 2009
We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis.
Putting the brakes on dietary fat breakdown.
Kühnlein, Göttingen, Germany. In Cell Metab, 2009
A Drosophila study (Sieber and Thummel, 2009 [this issue of Cell Metabolism]) now demonstrates that the orphan nuclear receptor DHR96 adjusts fat storage in flies by tuning gastric lipase expression.
Orlistat-associated adverse effects and drug interactions: a critical review.
Elisaf et al., Ioánnina, Greece. In Drug Saf, 2007
Interestingly, the use of orlistat has been associated with rare cases of acute kidney injury, possibly due to the increased fat malabsorption resulting from the inhibition of pancreatic and gastric lipase by orlistat, leading to the formation of soaps with calcium and resulting in increased free oxalate absorption and enteric hyperoxaluria.
Importance of the lid and cap domains for the catalytic activity of gastric lipases.
Canaan et al., Marseille, France. In Comp Biochem Physiol B Biochem Mol Biol, 2003
identidfied the cap and the lid residues involved in the binding with the lipidic substrate
Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase.
Armand et al., Marseille, France. In J Biol Chem, 2002
Mechanisms of inhibition of triacylglycerol hydrolysis
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