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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

YEATS domain containing 4

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Lysozyme, p53, NuMA, Histone
Papers on GAS41
Drosophila oncogene Gas41 is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway.
Bhadra et al., Hyderābād, India. In Febs J, 2015
Glioma amplified sequence41 (Gas41) is a highly conserved putative transcription factor that is frequently abundant in human gliomas.
Characterization and inhibition of AF10-mediated interaction.
Arndt et al., Potsdam, Germany. In J Pept Sci, 2014
The AF10 coiled-coil domain, which is crucial for the leukemogenic effect, has been shown to interact with GAS41, a protein previously identified as the product of an amplified gene in glioblastoma.
NuMA is required for the selective induction of p53 target genes.
Enari et al., Tokyo, Japan. In Mol Cell Biol, 2013
Although NuMA has been shown to colocalize with several nuclear proteins, including high-mobility-group proteins I and Y and GAS41, the role of NuMA during interphase remains unclear.
GAS41 amplification results in overexpression of a new spindle pole protein.
Meese et al., Homburg, Germany. In Genes Chromosomes Cancer, 2012
Previously, we identified a frequently amplified gene in glioma termed glioma-amplified sequence 41 (GAS41).
In vivo binding of Orc2 to a region of the chicken lysozyme GAS41 origin containing multiple Sp1-binding sites.
Phi-van et al., Celle, Germany. In Dna Cell Biol, 2012
The origin of bidirectional DNA replication of the chicken lysozyme GAS41 locus was identified in a CpG island covering the GAS41 gene promoter.
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
Roeder et al., Palmerston North, New Zealand. In J Biol Chem, 2011
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability
Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours.
Negri et al., Roma, Italy. In Acta Biochim Pol, 2010
Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas.
Sp1 and Sp3 regulate transcription of the chicken GAS41 gene.
Phi-van et al., Celle, Germany. In Biochim Biophys Acta, 2010
Mapping by a technique of indirect end labeling demonstrated that the Sp1-binding sites contained in this region exactly co-map with two previously identified DNase I hypersensitive (HS) sites, which suggests the important role of Sp1 binding in maintaining an open chromatin structure of the GAS41 promoter.
The YEATS family member GAS41 interacts with the general transcription factor TFIIF.
Meese et al., Homburg, Germany. In Bmc Mol Biol, 2009
The in vivo interaction of GAS41 and endogenous RAP30 and RAP74 was confirmed by co-immunoprecipitation. GAS41 binds to two non-overlapping regions of the C-terminus of RAP30.
The chromatin of active genes is not in a permanently open conformation.
Crane-Robinson et al., Portsmouth, United Kingdom. In J Mol Biol, 2009
Similar observations were made at the lysozyme locus containing the active Gas41 gene and also at the GAPDH locus.
YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.
Kobor et al., Vancouver, Canada. In Biochem Cell Biol, 2009
Yaf9, Taf14, and Sas5 are the only YEATS domain proteins in Saccharomyces cerevisiae.
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.
Pedeutour et al., Nice, France. In Int J Cancer, 2008
Overexpression of YEATS4 is associated with well-differentiated and dedifferentiated liposarcomas
A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma.
Meese et al., Homburg, Germany. In Mol Cancer Res, 2008
Expression analysis of the amplified region revealed 10 overexpressed genes (i.e., KUB3, CTDSP2, CDK4, OS-9, DCTN2, RAB3IP, FRS2, GAS41, MDM2, and RAP1B) that were consistently overexpressed in all cases that carried this amplification.
The chromatin structure of the lysozyme GAS41 origin of DNA replication changes during the cell cycle.
Phi-van et al., Celle, Germany. In Biol Res, 2006
Using this protocol, we analyzed the chromatin structure of the region surrounding two overlapping elements, an origin of bidirectional DNA replication and the GAS41 promoter, in chicken myelomonocytic HD11 cells arrested in G0, G1 and S phases as well as at the G1/S border.
The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication.
Klempnauer et al., Münster, Germany. In Bmc Mol Biol, 2006
We have recently demonstrated that the chicken Gas41 gene, whose promoter co-localizes with an origin of DNA replication, is a bona fide Myb target gene.
GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation.
Roeder et al., New York City, United States. In Mol Cell Biol, 2006
GAS41 plays a role in repressing the p53 tumor suppressor pathway during the normal cell cycle by a TIP60-independent mechanism.
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