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Growth arrest-specific 2 like 1

The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gas2, Actin, SET, merlin, beta-adaptin
Papers on GAR22
GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.
Ballestrem et al., Manchester, United Kingdom. In J Cell Sci, 2014
By using fluorescence microscopy, we demonstrate that three members of this family, GAS2-like 1, GAS2-like 2 and GAS2-like 3 (G2L1, G2L2 and G2L3, also known as GAS2L1, GAS2L2 and GAS2L3, respectively) are differentially involved in mediating the crosstalk between F-actin and MTs.
An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.
Akiyama et al., Mibu, Japan. In Psychiatry Res, 2011
There was no significant difference in the frequency six marker haplotype in the GAS2L1 gene between the cases of schizophreina and controls.
GAR22: a novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells.
Zenke et al., Aachen, Germany. In Exp Hematol, 2009
T3-induced genes identified basic transcription element binding protein 1/Kruppel-like factor 9 (BTEB1/KLF9) and GAR22 as TR target genes
Discovery of epigenetically silenced genes in acute myeloid leukemias.
Koeffler et al., Los Angeles, United States. In Leukemia, 2007
Gas2l1, tfIIs, ehd3, enolase 2, mx1, dral, astml and pxdn were diminished across all AML karyotypes examined.
[Cytogenetic alterations in meningioma tumors and their impact on disease outcome].
MaĆ­llo et al., Salamanca, Spain. In Med Clin (barc), 2007
Accordingly, while the presence of monosomy 22/22q-, associated with mutation of the NF2, BAM22, RRP22, GAR22, MN1, SMARCB1, CLH22 and/or LARGE genes, is associated with neoplasic transformation, other alterations such us monosomy 14, del(1p), different chromosomal abnormalities localized at 9p, 10q and 17q and complex karyotypes are frequently related to tumor progression.
Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines.
Kawasaki et al., Bethesda, United States. In Stem Cells Dev, 2006
GAS2L1 and GAS3 members of this family appear to be transcriptionally regulated by OCT4, SOX2, or NANOG, whereas GAS5 and GAS6 are not; all of the genes are differentially expressed, as determined by microarray and validated via quantitative (Q)- PCR.
Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules.
Liem et al., New York City, United States. In J Cell Sci, 2003
The beta isoforms of hGAR17 and hGAR22 appear to be able to crosslink microtubules and microfilaments
Expression of the mouse Macf2 gene during inner ear development.
Lomax et al., Ann Arbor, United States. In Brain Res Mol Brain Res, 2002
Characteristic features of macrophins include variable actin binding domains, a central rod domain containing both plectin and spectrin repeats, and a C-terminus containing EF hands and GAS2/GAR22 domain.
Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins.
Liem et al., New York City, United States. In J Cell Sci, 2001
Structurally, MACF can be divided into 3 domains: an N-terminal domain that contains both a calponin type actin-binding domain and a plakin domain; a rod domain that is composed of 23 dystrophin-like spectrin repeats; and a C-terminal domain that includes two EF-hand calcium-binding motifs, as well as a region that is homologous to two related proteins, GAR22 and Gas2.
Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region.
Thomas et al., Paris, France. In Genomics, 1997
One of them, GAR22, is closely related to mouse Gas2, a gene isolated as being negatively regulated by serum and growth factors and exhibiting a high expression in growth arrested mouse fibroblasts.
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