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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Actin, gamma 1

gamma-actin, ACTG
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: Actin, beta-actin, HAD, CAN, ACID
Papers on gamma-actin
Brief Report: Significant Decreases in Both Total and Unbound Lopinavir and Amprenavir Exposures During Coadministration: ACTG Protocol A5143/A5147s Results.
Collier et al., Chapel Hill, United States. In J Acquir Immune Defic Syndr, Jan 2016
This secondary analysis explored changes in protein-unbound concentrations of lopinavir and amprenavir when coadministered in HIV-infected subjects.
Ritchie et al., United States. In Pac Symp Biocomput, Dec 2015
Therefore in this study, we propose a pipeline to identify interactions among genetic variants that are associated with multiple phenotypes by prioritizing previously published results from main effect association analysis (genome-wide and phenome-wide association analysis) based on a-priori biological knowledge in AIDS Clinical Trials Group (ACTG) data.
Efficacy and Tolerability of Integrase Inhibitors in Antiretroviral-Naive Patients.
Abrescia et al., Napoli, Italy. In Aids Rev, Jul 2015
Raltegravir was also superior to atazanavir/ritonavir and darunavir/ritonavir in the ACTG 5257 study for the combined virologic/tolerability endpoint.
Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection.
Cai et al., Shanghai, China. In Plos One, 2014
The frequencies of the five haplotypes (high to low) were as follows: CCTG (0.328), ACTG (0.280), ACCT (0.189), ATTG (0.186) and ACCG (0.017).
Presence of Plasmodium falciparum DNA in Plasma Does Not Predict Clinical Malaria in an HIV-1 Infected Population.
Schooley et al., Boston, United States. In Plos One, 2014
METHODS: ACTG study A5175 compared two NNRTI-based regimens and one PI-based anti-retroviral (ARV) regimen in antiretroviral therapy naïve participants.
Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy.
Funderburg et al., Columbus, United States. In Plos One, 2014
METHODS: Cryopreserved peripheral blood mononuclear cells (PBMCs) were obtained at baseline (prior to ART initiation) and at weeks 12, 24, and 48 of treatment from 29 patients participating in ACTG clinical trial A5248, an open label study of raltegravir/emtricitibine/tenofovir administration.
Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells affect herpes simplex virus 1 infection and replication.
Wang et al., Guangzhou, China. In J Virol, 2012
These results showed the biphasic F-actin dynamics in herpes simplex virus 1 neuronal infection and confirmed the association of F-actin with the changes in the expression and activity of cofilin 1.
NNRTIs: future prospects.
Garraffo et al., Nice, France. In Med Mal Infect, 2012
Recent clinical data on efavirenz and nevirapine in naive patients confirms their effectiveness compared to protease inhibitors such as lopinavir/r (ACTG 5142) or atazanavir/r (ACTG 5202) for efavirenz, or such as atazanavir/r (ARTEN trial) for nevirapine.
De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.
Dobyns et al., Seattle, United States. In Nat Genet, 2012
identified de novo missense changes in the cytoplasmic actin-encoding genes ACTB and ACTG1 in one and two probands, respectively; suggest that Baraitser-Winter syndrome is the predominant phenotype associated with mutation of these two genes
γ-Actin regulates cell migration and modulates the ROCK signaling pathway.
Kavallaris et al., Australia. In Faseb J, 2011
knockdown of gamma-actin significantly reduced speed of motility and severely affected the cell's ability to explore, which was, in part, due to a loss of cell polarity
Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes.
Vassalli et al., Genève, Switzerland. In Biol Reprod, 2011
Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes.
β-Actin specifically controls cell growth, migration, and the G-actin pool.
Ervasti et al., Minneapolis, United States. In Mol Biol Cell, 2011
These data support an essential role for beta-actin in regulating cell migration and gene expression through control of the cellular G-actin pool
Efavirenz: a decade of clinical experience in the treatment of HIV.
Maggiolo, Bergamo, Italy. In J Antimicrob Chemother, 2009
In the ACTG A5142 study, efavirenz showed greater virological efficacy than the boosted protease inhibitor (PI), lopinavir.
Effects of nucleoside reverse transcriptase inhibitor backbone on the efficacy of first-line boosted highly active antiretroviral therapy based on protease inhibitors: meta-regression analysis of 12 clinical trials in 5168 patients.
Sawyer et al., Liverpool, United Kingdom. In Hiv Med, 2009
The ACTG 5202 and BICOMBO trials suggested higher efficacy for TDF/FTC, whereas the HEAT trial showed no efficacy difference between the nucleoside reverse transcriptase inhibitor (NRTI) backbones.
Short review of some properties of muscular proteins.
Jílek et al., Praha, Czech Republic. In Cesk Fysiol, 2007
Among the regulatory proteins, troponin, tropomyosin, M-protein, beta-actin, gamma-actin and C-protein are great importance.
Predictive value of quantitative plasma HIV RNA and CD4+ lymphocyte count in HIV-infected infants and children.
Baker et al., Newark, United States. In Jama, 1998
DESIGN: Data from a cohort of 566 infants and children who participated in a randomized, placebo-controlled trial of nucleoside reverse transcriptase inhibitors (ACTG 152) were analyzed.
Identification of a widespread nuclear actin binding protein.
Franke et al., Heidelberg, Germany. In Nature, 1990
This nucleus contains high concentrations (4-6 mg ml-1) of mostly soluble, although polymerization-competent beta- and gamma-actin, which exists in a nucleocytoplasmic exchange pool.
Smooth muscle alpha-action is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cells.
Jariwalla et al., In Nature, 1985
All human fibroblast strains, normal and transformed, synthesize two electrophoretic forms of actin (beta- and gamma-actin).
Cell commitment and gene expression in the axolotl embryo.
Slack et al., In Cell, 1980
In intact embryos beta-and gamma-actin are made at all stages of development and in all tissues.
Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products.
Cowan et al., In Cell, 1978
The mRNAs for beta- and gamma-actin have also been resolved on native gels, but migrate as an unresolved peak (molecular weight 6500,000-700,000 daltons) under denaturing conditions.
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