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Galactose-3-O-sulfotransferase 2

Gal3ST-2, GP3ST, Gal3ST-3, a Gal 3-O-sulphotransferase
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, sialyltransferase, V1a, Alpha-1
Papers on Gal3ST-2
3'-Sulfo-Le(x) is important for regulation of integrin subunit alphaV.
Wu et al., Shanghai, China. In Biochemistry, 2010
Carbohydrate structures with a 3'-sulfo betaGal linkage, such as 3'-sulfo-Le(x), can be synthesized by Gal:3-O-sulfotransferase-2 (Gal3ST-2) catalysis, but little is known about their roles in many biological processes.
Polyoxometalates as effective inhibitors for sialyl- and sulfotransferases.
Yamashita et al., Yokohama, Japan. In J Inorg Biochem, 2009
By certain vanadate-type PMs, ST3Gal-I and Gal 3-O-sulfotransferase-2 (Gal3ST-2) were specifically inhibited at nanomolar levels.
Serum 3'-sulfo-Lea indication of gastric cancer metastasis.
Wu et al., Shanghai, China. In Clin Chim Acta, 2009
Cell adhesion to HUVEC and sL-selectin, and cell migration were performed in gastric cancer cells SCG7901 with 3'-sulfo-Le(a) silence by Gal3ST-2 RNAi.
In vitro sulfation of N-acetyllactosaminide by soluble recombinant human beta-Gal-3'-sulfotransferase.
Thiem et al., Hamburg, Germany. In Carbohydr Res, 2006
Membrane-bound beta-Gal-3'-sulfotransferase (GP3ST) was expressed and used for in vitro sulfation of Tamm-Horsfall glycoprotein.
Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activity.
Yamashita et al., Tokyo, Japan. In Biochem J, 2005
The substrate specificity and cofactor requirements of human, porcine, and murine GAL3ST are reported
Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins.
Wu et al., Shanghai, China. In Biochem Biophys Res Commun, 2005
Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3
Down-regulation of Gal 3-O-sulfotransferase-2 (Gal3ST-2) expression in human colonic non-mucinous adenocarcinoma.
Yamashita et al., Tokyo, Japan. In Jpn J Cancer Res, 2002
In this study, we first examined the substrate specificities of four Gal3STs cloned so far, and found that Galbeta1 3GlcNAcbeta1 3Galbeta1 4Glc (LNT) can be utilized only by Gal3ST-2 as an acceptor substrate.
The possibility of reducing xenoantigen levels with a novel gal 3'-sulfotransferase (GP3ST).
Taniguchi et al., Suita, Japan. In J Biochem, 2002
Glycoprotein-3-sulfotransferase (GP3ST) is a key enzyme in downregulating the expression of Galalpha1,3Galbeta1,4GlcNAc-R (the alpha-Gal epitope), via enzymatic competition with an alpha1,3 galactosyltransferase (alpha1,3GT), such as alpha2,6 sialyltransferase (alpha2,6ST).
A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes.
Honke et al., Suita, Japan. In J Biol Chem, 2001
To elucidate the physiological functions of 3'-sulfated Lewis epitopes, a remodeling system was developed using a combination of a betaGal-3-O-sulfotransferase GP3ST, hitherto known alpha1,3/1,4-fucosyltransferases (FucT-III, IV, V, VI, VII, and IX) and arylsulfatase A. The pyridylaminated (PA) lacto-N-tetraose (Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc) was first converted to 3'-sulfolacto-N-fucopentaose II (sulfo-3Galbeta1-3(Fucalpha1-4)GlcNAcbeta1-3Galbeta1-4Glc)-PA by sequential reactions with GP3ST and FucT-III.
A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc.
Muramatsu et al., Nagoya, Japan. In J Biol Chem, 2001
The novel sulfotransferase gene was present on human chromosome 11q13; the location was different from human CST and from that of the recently cloned human beta-Gal 3'-sulfotransferase (GP3ST).
Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans.
Yamashita et al., Tokyo, Japan. In J Biol Chem, 2001
The amino acid sequence of Gal3ST-4 revealed 33%, 39%, and 30% identity to human Gal3ST-1, Gal beta 1-->3/4GlcNAc:-->3'-sulfotransferase (Gal3ST-2) and Gal beta 1-->4GlcNAc:-->3'-sulfotransferase (Gal3ST-3), respectively.
Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans.
Fukuda et al., Los Angeles, United States. In J Biol Chem, 2001
Moreover, Gal3ST-3 but not Gal3ST-2 can act on Galbeta1-->4(sulfo-->6)GlcNAc, indicating that disulfated sulfo-->3Galbeta1-->4(sulfo-->6) GlcNAc-->R may be formed by Gal3ST-3 in combination with GlcNAc 6-O-sulfotransferase.
Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides.
Taniguchi et al., Suita, Japan. In J Biol Chem, 2001
A novel sulfotransferase gene (designated GP3ST) was identified on human chromosome 2q37.3
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