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Cyclin G associated kinase

GAK, cyclin G-associated kinase
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CAN, p15, HSC70, HAD
Papers using GAK antibodies
Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals
Höning Stefan et al., In The Journal of Cell Biology, 1995
... GAK was identified by a monoclonal antibody (MoBiTec) or a rabbit serum provided ...
Papers on GAK
The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
Xu et al., Nanchang, China. In Mol Neurobiol, Jan 2016
UNASSIGNED: The genetic factors about the pathogenesis of sporadic Parkinson's disease (sPD) is not completely clear at present; therefore, we performed a genome-wide association study, high-throughput sequencing analysis (HTPSA) of all cyclin G-associated kinase (GAK) exons, loss-of-function assessment, and sorting intolerant from tolerant analysis of HTPSA data in 250 typical sPD and 250 controls, which found 55 candidate single nucleotide polymorphisms (SNPs).
The clathrin-binding and J-domains of GAK support the uncoating and chaperoning of clathrin by Hsc70 in the brain.
Greene et al., Bethesda, United States. In J Cell Sci, Nov 2015
Cyclin-G-associated kinase (GAK), the ubiquitously expressed J-domain protein, is essential for the chaperoning and uncoating of clathrin that is mediated by Hsc70 (also known as HSPA8).
Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.
Jiang et al., Harbin, China. In Tumour Biol, Sep 2015
We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005).
Quantitative assessment of the association between GAK rs1564282 C/T polymorphism and the risk of Parkinson's disease.
Xu et al., Qingdao, China. In J Clin Neurosci, Jul 2015
The aim of this meta-analysis was to evaluate the association between cyclin G-associated kinase (GAK) rs1564282 C/T polymorphism and Parkinson's disease (PD) susceptibility.
The endosomal pathway in Parkinson's disease.
Tofaris et al., Oxford, United Kingdom. In Mol Cell Neurosci, May 2015
In this review, we summarized the evidence that a number of Parkinson's associated genetic mutations or polymorphisms (LRRK2, VPS35, GBA, ATP13A2, ATP6AP2, DNAJC13/RME-8, RAB7L1, GAK) disrupt protein trafficking and degradation via the endosomal pathway and discussed how such defects could arise from or contribute to the accumulation and misfolding of α-synuclein in Lewy bodies.
Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.
Herdewijn et al., Leuven, Belgium. In J Med Chem, May 2015
Cyclin G associated kinase (GAK) emerged as a promising drug target for the treatment of viral infections.
AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
Einav et al., Stanford, United States. In J Virol, Apr 2015
AP-2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in the endocytic and secretory pathways.
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Singleton et al., Bethesda, United States. In Nat Genet, 2014
Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant.
Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630.
Nojima et al., Suita, Japan. In Plos One, 2013
Cyclin G-associated kinase (GAK), a key player in clathrin-mediated membrane trafficking, is overexpressed in various cancer cells.
Early amniocentesis as a method of choice in diagnosing gynecological diseases.
Mehmedbasic et al., Sarajevo, Bosnia and Herzegovina. In Acta Inform Med, 2013
Performed is 299 analysis of amniotic fluid after amnion puncture done in the Institute or at the Clinic of Gynecology and Obstetrics (GAK) Sarajevo.
Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease.
Chen et al., Shanghai, China. In Prog Neurobiol, 2012
Causative and risk gene products associated with PD include protein kinases (such as PINK1, LRRK2 and GAK) and proteins related phosphorylation signaling pathways (such as SNCA, DJ-1).
GWAS-linked GAK locus in Parkinson's disease in Han Chinese and meta-analysis.
Peng et al., Chengdu, China. In Hum Genet, 2012
study demonstrated that the rs1564282 variant in GAK (PARK17) increases the risk of Parkinson's disease in Han Chinese patients from mainland China
Cyclin G-associated kinase regulates protein phosphatase 2A by phosphorylation of its B'γ subunit.
Nojima et al., Suita, Japan. In Cell Cycle, 2012
GAK as a regulator of dephosphorylation events under the control of the PP2A B'gamma subunit.
Genetic variants in sporadic Parkinson's disease: East vs West.
Tan et al., Singapore, Singapore. In Parkinsonism Relat Disord, 2012
Numerous GWAS linked loci including BST1 (bone marrow stromal cell antigen 1), PARK16 (parkinson disease 16 susceptibility), GAK (cyclin G associated kinase), and HLA (human leukocyte antigen) have also been identified.
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.
Myers et al., Boston, United States. In Hum Mol Genet, 2011
cyclin G associated kinase is associated with Parkinson disease risk and suggest that cyclin G associated kinase and alpha-synuclein interact in a pathway involved in disease pathogenesis
Replication of GWAS associations for GAK and MAPT in Parkinson's disease.
Ritz et al., Los Angeles, United States. In Ann Hum Genet, 2011
GAK is a new candidate for investigation in future studies.
Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction.
Nojima et al., Ōsaka, Japan. In Plos One, 2010
These results suggest that inhibition of GAK by gefitinib may cause pulmonary alveolar dysfunction.
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
Payami et al., Albany, United States. In Nat Genet, 2010
We confirmed associations with SNCA and MAPT, replicated an association with GAK (using data from the NGRC and a previous study, P = 3.2 x 10(-9)) and detected a new association with the HLA region (using data from the NGRC only, P = 2.9 x 10(-8)), which replicated in two datasets (meta-analysis P = 1.9 x 10(-10)).
Endocytosis: clathrin-mediated membrane budding.
Hinrichsen et al., Hannover, Germany. In Curr Opin Cell Biol, 2007
Finally, a burst of auxilin/GAK initiates the uncoating of the vesicle.
Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis.
Drubin et al., Berkeley, United States. In Nat Cell Biol, 2005
The yeast protein kinases Prk1p and Ark1p, which are related to the mammalian proteins GAK and AAK1, are key regulators of this process.
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