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Chromosome 6 open reading frame 25

G6b, immunoglobulin-receptor, G6b protein
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Syk, C-reactive protein, NS1, SHP1
Papers on G6b
An investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b.
Campbell et al., Oxford, United Kingdom. In Plos One, 2011
G6B-b is an inhibitory platelet receptor with an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM).
Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets.
Gibbins et al., Reading, United Kingdom. In Proteomics, 2009
Furthermore, many platelet proteins revealed changes in location associated with function, including G6B and Hip-55.
An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus.
Dehnugara et al., Leicester, United Kingdom. In Hum Mutat, 2009
The immunoglobulin-receptor genes FCGR3A and FCGR3B on chromosome 1q23.3
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.
Watson et al., Birmingham, United Kingdom. In J Biol Chem, 2009
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.
G6b-B cell surface inhibitory receptor expression is highly restricted to CD4+ T-cells and induced by interleukin-4-activated STAT6 pathway.
Deng et al., New York City, United States. In Hum Immunol, 2007
G6b-B expression is highly restricted to peripheral CD4+ T cells and up-regulated by the IL-4-induced STAT6 pathway, suggesting that G6b-B is involved in regulation of the immune response by CD4+ T cell-mediated and IL-4 induced regulatory mechanisms.
The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro.
Campbell et al., Cambridge, United Kingdom. In Blood, 2007
G6B represents a novel inhibitory receptor found on the surface of platelets
The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin.
Campbell et al., Cambridge, United Kingdom. In Febs Lett, 2005
Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand
Secretory antibodies do not affect the composition of the bacterial microbiota in the terminal ileum of 10-week-old mice.
Janssen et al., Melbourne, Australia. In Appl Environ Microbiol, 2003
Polymeric-immunoglobulin-receptor-deficient (pIgR(-/-)) mice that were unable to secrete antibodies across mucosal surfaces were cohoused with normal and otherwise genetically identical wild-type (C57BL/6) mice for 4 weeks.
Single-nucleotide polymorphism detection by denaturing high-performance liquid chromatography and direct sequencing in genes in the MHC class III region encoding novel cell surface molecules.
Campbell et al., Cambridge, United Kingdom. In Immunogenetics, 2001
These molecules are members of two different superfamilies, the immunoglobulin superfamily (1C7, G6B, and G6F genes) and the leucocyte antigen-6 superfamily (G6C, G6D, G6E, G5C, and G5B genes).
Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.
Campbell et al., Oxford, United Kingdom. In J Immunol, 1999
The sequence analysis has revealed the localization of seven genes, whose precise position and order is cen-G7-G6-G6A-G6B-G6C-G6D-G6E-tel, five of which are fully encoded in the sequence, allowing their genomic structures to be defined.
Secretory component, the receptor for polymeric immunoglobulin, has nothing to do with beta-galactosyltransferase in human milk.
Taniguchi et al., Sapporo, Japan. In Immunol Lett, 1996
Secretory component (SC) in external secretions is a soluble form of the polymeric immunoglobulin-receptor that is expressed on the cell membrane of mucosal epithelial cells.
Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.
Marshak-Rothstein et al., Boston, United States. In Nature, 1995
Protection against Fas-dependent apoptosis afforded by immunoglobulin-receptor engagement may constitute a fail-safe mechanism that eliminates bystander B cells activated by CD40L-expressing T cells, but ensures survival of antigen-specific B cells.
Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.
Hodgkin et al., Australia. In Proc Natl Acad Sci U S A, 1994
In contrast, the low immunoglobulin receptor levels on anergic B cells were associated with reduced de novo presentation of HEL and a failure to upregulate costimulatory ligands for CD28.
The role of clonal selection and somatic mutation in autoimmunity.
Weigert et al., In Nature, 1987
They harbour numerous somatic mutations which are distributed in a way that suggests immunoglobulin-receptor-dependent selection of these mutations.
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