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RNA binding motif protein 6

G16, 3G2, RNF5, RBM6
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, G-15, HAD, CAN, ACID
Papers on G16
Synthesis, antiviral activity, 3D-QSAR, and interaction mechanisms study of novel malonate derivatives containing quinazolin-4(3H)-one moiety.
Song et al., Guiyang, China. In Bioorg Med Chem Lett, Feb 2016
Notably, compounds g15, g16, g17, and g18 exhibited excellent curative activities in vivo against CMV, with 50% effective concentration (EC50) values of 208.36, 153.78, 181.47, and 164.72μg/mL, respectively, which were better than that of Ningnanmycin (256.35μg/mL) and Ribavirin (523.34μg/mL).
Triple-layer dissection of the lung adenocarcinoma transcriptome: regulation at the gene, transcript, and exon levels.
Chen et al., Yü-ching, Taiwan. In Oncotarget, Nov 2015
Of the 28 selected exonic regions, 26 regions correspond to alternative exons located in such regulators as tumor suppressor (GDF10), signal receptor (LYVE1), vascular-specific regulator (RASIP1), ubiquitination mediator (RNF5), and transcriptional repressor (TRIM27).
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
Ronai et al., Los Angeles, United States. In Cancer Cell, Apr 2015
We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the ubiquitin ligase RNF5.
Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.
Pedemonte et al., Genova, Italy. In Sci Rep, 2014
Our analysis identified RNF5 as a protein whose inhibition promoted significant F508del-CFTR rescue and displayed an additive effect with the investigational drug VX-809.
RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.
Shu et al., Wuhan, China. In Plos Pathog, 2014
Interestingly, RNF26 promoted K11-linked polyubiquitination of MITA at lysine 150, a residue also targeted by RNF5 for K48-linked polyubiquitination.
Leptin does not induce an inflammatory response in the murine placenta.
Dötsch et al., Köln, Germany. In Horm Metab Res, 2014
from day g13 to g16, resulting in a 3-fold increase of maternal circulating serum leptin levels.
Autoadaptive ER-associated degradation defines a preemptive unfolded protein response pathway.
Molinari et al., Bellinzona, Switzerland. In Mol Cell, 2014
We show that HRD1 dislocon integrity relies on the presence of HRD1 clients that interrupt, in a dose-dependent manner, the UBC6e/RNF5/p97/proteasome-controlled relay that controls HERP turnover.
RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Valcárcel et al., Barcelona, Spain. In Mol Cell, 2014
RBM5, a regulator of alternative splicing of apoptotic genes, and its highly homologous RBM6 and RBM10 are RNA-binding proteins frequently deleted or mutated in lung cancer.
RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).
Delaunay-Moisan et al., Gif-sur-Yvette, France. In J Biol Chem, 2013
Cystic fibrosis transmembrane conductance regulator (CFTR) is one ERAD substrate targeted to co-translational degradation by the E3 ligase RNF5/RMA1.
Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.
Parent et al., Sherbrooke, Canada. In Mol Endocrinol, 2013
Among β2AR-associated proteins is Ring finger protein 5 (RNF5), an E3 ubiquitin ligase anchored to the outer membrane of the ER.
Roles of 17-AAG-induced molecular chaperones and Rma1 E3 ubiquitin ligase in folding and degradation of Pendrin.
Hahn et al., Seoul, South Korea. In Febs Lett, 2012
Rma1, an E3 ubiquitin ligase localized in the ER membrane, is involved in Pendrin degradation
Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.
Ronai et al., Los Angeles, United States. In Plos Genet, 2011
Here, we show that the membrane-associated E3 ligase RNF5 regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B.
The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.
Cyr et al., Chapel Hill, United States. In Mol Biol Cell, 2011
JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTRDeltaF508 for degradation.
RBM5 as a putative tumor suppressor gene for lung cancer.
Robinson et al., Greater Sudbury, Canada. In J Thorac Oncol, 2010
RBM5 is one member of a group of structurally related genes that includes RBM6 and RBM10.
Roles of E3 ubiquitin ligases in cell adhesion and migration.
Huang, Chapel Hill, United States. In Cell Adh Migr, 2010
RNF5 and XRNF185 modulate cell migration by ubiquitinating paxillin.
Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).
Ronai et al., Los Angeles, United States. In J Biol Chem, 2009
RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP.
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
Shu et al., Wuhan, China. In Immunity, 2009
E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner
RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours.
Sutherland et al., Greater Sudbury, Canada. In Bmc Genomics, 2006
RBM6 mRNA experiences altered co-transcriptional gene regulation in certain cancers. RBM6-RBM5 transcription-induced chimerism might be a process that is linked to the tumour-associated increased transcriptional activity of the RBM6 gene
Detection of exfoliated bladder cancer cells by monoclonal antibodies to tumor-associated cell surface antigens.
Prout et al., Boston, United States. In J Occup Med, 1990
A Mab generated by our laboratory, 3G2-C6, reacts with high affinity to a cell-surface component expressed by bladder tumor cells.
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