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BCL2-associated athanogene 6

G-3, BAT3, Scythe, HLA-B-associated transcript 3
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HLA-B, CAN, Ubiquitin, MHC, HSP70
Papers using G-3 antibodies
The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.
Buratti Emanuele, In PLoS ONE, 2009
... Antibodies against the hemagglutinin (HA) epitope tag were purchased from Roche (3F10), antibodies against BAT3 were obtained from Abcam (ab88292).
Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells.
Zimmer Jacques, In PLoS ONE, 2006
... Multhoff, München) and chicken polyclonal anti-BAT3 (ab37751, Abcam, Germany) ...
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
Ashwell Jonathan D., In PLoS Biology, 2004
... Anti-p97 and anti-BAT3 antibodies were purchased from Fitzgerald Industries and Abcam, respectively ...
Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.
Tailleux Ludovic, In PLoS ONE, 1996
... Primers used in the cloning and real-time PCR of BAT3 were designed with Oligoperfect Designer software (Life Technologies, NY) and are described ...
Papers on G-3
A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.
Kawahara et al., Tokyo, Japan. In Febs J, Jan 2016
UNASSIGNED: BAG6 (also called Scythe) interacts with the exposed hydrophobic regions of newly synthesized proteins and escorts them to the degradation machinery through mechanisms that remain to be elucidated.
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Liaudet-Coopman et al., Montpellier, France. In Oncotarget, Oct 2015
We identified TRPS1 (tricho-rhino-phalangeal-syndrome 1), a repressor of GATA-mediated transcription, and BAT3 (Scythe/BAG6), a nucleo-cytoplasmic shuttling chaperone protein, as new Cath-D-interacting nuclear proteins.
mRNA encoding Sec61β, a tail-anchored protein, is localized on the endoplasmic reticulum.
Palazzo et al., Toronto, Canada. In J Cell Sci, Oct 2015
Our data suggests that this process is independent of p180 (also known as RRBP1), a known mRNA receptor on the ER, and the transmembrane domain recognition complex (TRC) pathway components, TRC40 (also known as ASNA1) and BAT3 (also known as BAG6).
Inhibition of the NF-κB signaling pathway by a novel heterocyclic curcumin analogue.
Vanden Berghe et al., Thessaloníki, Greece. In Molecules, 2014
Our novel curcumin analogue BAT3 was identified to be the most potent NF-κB inhibitor and EMSA assays clearly showed inhibition of NF-κB/DNA-binding in the presence of BAT3, in agreement with reporter gene results.
NKp44 and Natural Cytotoxicity Receptors as Damage-Associated Molecular Pattern Recognition Receptors.
Mathew et al., Fort Worth, United States. In Front Immunol, 2014
Recent identification of the cellular ligands for NKp44 and NKp30 as exosomal proliferating cell nuclear antigen (PCNA) and HLA-B-associated transcript 3 (BAT3), respectively, implicate that NCRs may function as receptors for damage-associated molecular pattern (DAMP) molecules.
BAG-6, a jack of all trades in health and disease.
Koch et al., Frankfurt am Main, Germany. In Cell Mol Life Sci, 2014
BCL2-associated athanogene 6 (BAG-6) (also Bat-3/Scythe) was discovered as a gene product of the major histocompatibility complex class III locus.
Papillomavirus binding factor (PBF) is an intrinsically disordered protein with potential participation in osteosarcoma genesis, in silico evidence.
Barrón et al., Mexico. In Theor Biol Med Model, 2013
The in silico analysis to find out PBF interactions with cellular factors, confirmed the experimentally demonstrated interaction of PBF with two key cellular proteins involved in regulation of cellular apoptosis, 14-3-3β and Scythe/BAT3 proteins.
Genetic susceptibility to lung cancer and co-morbidities.
Fong et al., Brisbane, Australia. In J Thorac Dis, 2013
Large scale, multi-cohort GWAS of mainly Caucasian, smoking, populations have identified strong associations for lung cancer mapped to chromosomal regions 15q [nicotinic acetylcholine receptor (nAChR) subunits: CHRNA3, CHRNA5], 5p (TERT-CLPTM1L locus) and 6p (BAT3-MSH5).
Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.
Ye et al., Bethesda, United States. In Bioessays, 2013
The key component, Bag6/Bat3/Scythe, can effectively shield long hydrophobic segments exposed on the surface of a polypeptide, preventing aggregation or inappropriate interactions before a triaging decision is made.
HLA-dependent tumour development: a role for tumour associate macrophages?
Masucci et al., Stockholm, Sweden. In J Transl Med, 2012
BAT3, a positive regulator of MHC class II expression in normal macrophages, seems to be secreted by TAMs, consequently lacking its intracellular function, it looks like acting as an immunosuppressive factor.In conclusion HLA could cover a considerable role in tumour-development orchestrated by tumour-associated macrophages.
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Kuchroo et al., Boston, United States. In Nat Med, 2012
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion.
Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.
Wang et al., Durham, United States. In Embo J, 2012
These findings identify a novel role for Bat3 in regulating DOT1L function, which plays a critical role in DNA damage response.
Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis.
Fadeel et al., Stockholm, Sweden. In Febs Lett, 2012
Data show that cleavage of Scythe by caspase-3 occurs after activation of both the extrinsic (i.e. Fas/APO-1-mediated) and the intrinsic (i.e. staurosporine-induced) apoptosis pathway.
A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localization.
Koch et al., Bonn, Germany. In Plos One, 2011
Cell type-specific subcellular expression of BAT3 suggests distinct functions in the cytosol and in the nucleus.
BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum.
Ploegh et al., Cambridge, United States. In Plos One, 2010
BAT3, a cytosolic chaperone, is recruited to the site of dislocation through its interaction with Derlin2.
A ribosome-associating factor chaperones tail-anchored membrane proteins.
Hegde et al., Bethesda, United States. In Nature, 2010
Here we identify a conserved three-protein complex composed of Bat3, TRC35 and Ubl4A that facilitates TA protein capture by TRC40.
Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma.
Christiani et al., Boston, United States. In J Clin Oncol, 2010
High-order interactions among reflux, BMI, smoking, and functional polymorphisms in five apoptotic genes (FAS, FASL, IL1B, TP53BP, and BAT3) were investigated by entropy-based multifactor dimensionality reduction (MDR), classification and regression tree (CART), and traditional logistic regression (LR) models.
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
Houlston et al., United Kingdom. In Nat Genet, 2008
Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.
Engert et al., Köln, Germany. In Immunity, 2007
HLA-B-associated transcript 3 (BAT3) was released from tumor cells, bound directly to NKp30, and engaged NKp30 on NK cells. BAT3 triggered NKp30-mediated cytotoxicity and was necessary for tumor rejection in a multiple myeloma model.
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