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Frizzled family receptor 10

FZD10, Frizzled10
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Frizzled, FZD3, FZD7, ACID, FZD5
Papers on FZD10
Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
Towler et al., Grand Rapids, United States. In Circ Res, Aug 2015
Survey of ligands and Frizzled (Fzd) receptor profiles in LRP6-VKO revealed upregulation of canonical and noncanonical Wnts alongside Fzd10.
SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier.
Toguchida et al., Kyoto, Japan. In Plos One, 2014
We found that the expression of FZD10, identified as an SS-specific gene, was induced by SS18-SSX at the PSC and NCC stages, but not at the MSC stage.
Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathway.
Cheng et al., Wuhan, China. In Int J Oncol, 2014
Additionally, the activity of Wnt/β-catenin signaling appears to be consistent with Fzd10 expression.
Concentration-dependent effects of WNTLESS on WNT1/3A signaling.
Burrus et al., San Francisco, United States. In Dev Dyn, 2014
These effects appear to be Wnt-specific as overexpression of WLS inhibits the expression of FZD10, a target of β-catenin-dependent transcription.
Validation of DNA promoter hypermethylation biomarkers in breast cancer--a short report.
Moelans et al., Utrecht, Netherlands. In Cell Oncol (dordr), 2014
METHODS: The methylation status of a panel of 19 candidate genes (AKR1B1, ALX1, ARHGEF7, FZD10, GHSR, GPX7, GREM1, GSTP1, HOXD1, KL, LHX2, MAL, MGMT, NDRG2, RASGRF2, SFRP1, SFRP2, TM6SF1 and TMEFF2) was determined in formalin-fixed paraffin-embedded normal breast and breast cancer tissue samples using gel-based methylation-specific PCR (MSP).
Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.
Burrus et al., San Francisco, United States. In Dev Dyn, 2014
RESULTS: In this report, we show that the spatiotemporal expression patterns of FZD10 and WNT1/WNT3A are highly correlated.
Genome-wide microarray-based analysis of miRNAs expression in patients with acute-on-chronic liver failure.
Deng et al., Chongqing, China. In Hepatobiliary Pancreat Dis Int, 2014
CARD8, BCL2, IL1RAPL1, LTB, FZD10 and EDA were identified as the target genes of hsa-miR-16; MAP4K3, OPRM1, IGF2BP1 and CERCAM were verified as the target genes of hsa-let-7a.
Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders.
Riancho et al., Santander, Spain. In Gene, 2014
Six genes showed significant methylation differences between both groups of patients: FZD10, TBL1X, CSNK1E, WNT8A, CSNK1A1L and SFRP4.
BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10.
Song et al., Guangzhou, China. In Nat Commun, 2013
These effects are mediated by epigenetic silencing of FZD10, a receptor for Wnt signalling, through HDAC1 recruitment and histone H3K9 deacetylation at the promoter.
Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation.
Seruca et al., Porto, Portugal. In Bmc Cancer, 2013
Additionally, FZD6 and FZD10 genes, known to act as negative regulators of the canonical WNT signaling cascade and as positive regulators of the planar cell polarity (PCP) pathway, a non-canonic WNT pathway, were found to be up-regulated in P252H cells.
Genome-wide association study of a quantitative disordered gambling trait.
Slutske et al., Brisbane, Australia. In Addict Biol, 2013
Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status.
Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells.
Neth et al., München, Germany. In Biol Chem, 2012
Fzd9 and Fzd10 were not expressed in hMSCs.
Frizzled-10 promotes sensory neuron development in Xenopus embryos.
Wheeler et al., Norwich, United Kingdom. In Dev Biol, 2009
Results suggest that Frizzed 10 mediates Wnt1 signalling to determine sensory neural differentiation in Xenopus in vivo and in mouse cell culture.
Expression of Frizzled10 in mouse central nervous system.
Zhao et al., Nanjing, China. In Gene Expr Patterns, 2009
Frizzled10 expression is very strong during embryonic development of the CNS and may play an essential role in spatial and temporal regulation during neural development.
Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.
Toguchida et al., Kyoto, Japan. In Cancer Sci, 2009
there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10
Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development.
Zhao et al., Nanjing, China. In Genesis, 2009
Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development.
Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.
Katagiri et al., Tokyo, Japan. In Oncogene, 2009
FZD10 transactivation causes the activation of the Dvl-Rac1-JNK pathway and is associated with the development/progression of synovial sarcomas
WNT signaling in stem cell biology and regenerative medicine.
Katoh, Tokyo, Japan. In Curr Drug Targets, 2008
FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10, LRP5, LRP6, and ROR2 are transmembrane receptors transducing WNT signals based on ligand-dependent preferentiality for caveolin- or clathrin-mediated endocytosis.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
FZD4 and FZD10 are up-regulated in NT2 cells after ATRA treatment.
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