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Fragile X mental retardation, autosomal homolog 2

FXR2, Fxr2h, FMR1L2
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FMR1, FXR1, beta 2-adrenoceptor, CAN, STEP
Papers on FXR2
Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.
Zhao et al., Beijing, China. In Cell Rep, Jul 2015
In the present study, we discovered that FXR2P (also known as FXR2) is important for neuronal dendritic development.
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
Ehrenreich et al., Göttingen, Germany. In Embo Mol Med, 2014
It is unknown, however, whether normal variants (independent of mutations) in the fragile X gene family (FMR1, FXR1, FXR2) and in FMR2 modulate autistic features.
Gene expression profiles on predicting protein interaction network and exploring of new treatments for lung cancer.
Zhang et al., Shenyang, China. In Mol Biol Rep, 2014
In addition, three DGEs, FXR2, ARFGAP1 and ELAVL1 were discovered as potential lung cancer related genes.
De novo duplication of 17p13.1-p13.2 in a patient with intellectual disability and obesity.
Kurosawa et al., Yokohama, Japan. In Am J Med Genet A, 2014
encompassing TP53, FXR2, NLGN2, and SLC2A4, which encodes the insulin-responsive glucose transporter 4 (GLUT4) associated with insulin-stimulated glucose uptake in adipocytes and muscle.
Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.
Huang et al., Philadelphia, United States. In Embo J, 2013
We identified a novel ribonucleoprotein (RNP) complex, consisting of RNA-binding proteins (hnRNP K, FXR1, and FXR2), PUF60 and SF3B3, that is required for this treRNA functions.
FMRP targets distinct mRNA sequence elements to regulate protein expression.
Tuschl et al., New York City, United States. In Nature, 2013
Here we report the discovery of distinct RNA-recognition elements that correspond to the two independent RNA-binding domains of FMRP, in addition to the binding sites within the messenger RNA targets for wild-type and I304N mutant FMRP isoforms and the FMRP paralogues FXR1P and FXR2P (also known as FXR1 and FXR2).
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases.
Yamamoto et al., Tokyo, Japan. In Gene Regul Syst Bio, 2012
The set of ChIP-Seq-based NRF1 target genes included known NRF1 targets such as EIF2S1, EIF2S2, CYCS, FMR1, FXR2, E2F6, CD47, and TOMM34.
FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124.
Gao et al., San Francisco, United States. In J Neurosci, 2011
Surprisingly, the levels of miR-9 and miR-124 are elevated in fmr1/fxr2 double-knock-out mice, in part reflecting posttranscriptional upregulation of FXR1P.
RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.
Zhao et al., Albuquerque, United States. In Neuron, 2011
Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.
Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.
Broadie et al., Nashville, United States. In Dis Model Mech, 2010
These results indicate that FMR1 gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.
17p13.1 microdeletion involving the TP53 gene in a boy presenting with mental retardation but no tumor.
Edery et al., Lyon, France. In Am J Med Genet A, 2010
Array CGH using a 244 K oligonucleotide array showed a homogeneous de novo 17p13.1 microdeletion of 400 kb involving TP53 and 25 other genes, including genes involved in brain function (EFNB3, FXR2).
Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Min et al., Toronto, Canada. In Plos One, 2009
Data show that the nuclear localization signals of the FXR1 and FXR2 comprise tandem Tudor domain architectures.
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.
Darnell et al., New York City, United States. In Hum Mol Genet, 2009
FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.
Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish.
Willemsen et al., Rotterdam, Netherlands. In J Exp Biol, 2009
We know little of the roles that fragile X related (FXR) gene family members (FMR1, FXR2 and FXR1) play during embryonic development.
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons.
de Vrij et al., Rotterdam, Netherlands. In Neurobiol Dis, 2009
Co-transfection of FXR2, an FMRP homologue, also resulted in redistribution of both variants into dendritic RNA-granules.
Genes and pathways differentially expressed in the brains of Fxr2 knockout mice.
Oostra et al., Catania, Italy. In Neurobiol Dis, 2008
to unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice; genes and gene groups de-regulated in the brains of Fxr2 knockout mice were identified
Molecular mechanisms of fragile X syndrome.
Siomi et al., Tokushima, Japan. In J Med Invest, 2000
FMR1 encodes a cytoplasmic RNA-binding protein which interacts with two autosomal homologs, FXR1 and FXR2.
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