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Fragile X mental retardation, autosomal homolog 1

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FMR1, FXR2, CAN, beta 2-adrenoceptor, ACID
Papers on FXR1
A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.
Greenwood et al., Shanghai, China. In J Affect Disord, Feb 2016
RESULTS: The most significant genome-wide finding was observed bipolar with comorbid eating disorder vs. controls within SOX2-OT (p=8.9×10(-8) for rs4854912) with a secondary peak in the adjacent FXR1 gene (p=1.2×10(-6)
Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung.
Massion et al., Nashville, United States. In Genom Data, Sep 2015
We further demonstrated one of the 12 top amplified driver Fragile X mental retardation-related protein 1 (FXR1) as a novel cancer gene in NSCLC and FXR1 executes its regulatory function by forming a novel complex with two other oncogenes, protein kinase C, iota ( PRKCI) and epithelial cell transforming 2 (ECT2) within the same amplicon in lung cancer cell.
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
Ehrenreich et al., Göttingen, Germany. In Embo Mol Med, 2014
It is unknown, however, whether normal variants (independent of mutations) in the fragile X gene family (FMR1, FXR1, FXR2) and in FMR2 modulate autistic features.
Gene expression analysis at the onset of sex differentiation in turbot (Scophthalmus maximus).
Viñas et al., Santiago de Compostela, Spain. In Bmc Genomics, 2014
Two genes placed on the SD region of turbot (sox2, fxr1) did not show any expression pattern suggestive of a sex determining function.
Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein.
Zarnescu et al., Tucson, United States. In Plos One, 2014
More recently, alterations in the levels of Fragile X Related 1 protein, FXR1, the predominant FraX member expressed in vertebrate striated muscle, have been linked to structural and functional defects in mice and zebrafish models.
The construction of cDNA library and the screening of related antigen of ascitic tumor cells of ovarian cancer.
Shan et al., In Eur J Gynaecol Oncol, 2014
They were then divided into six categories: (1) the homologous genes which related to the known ovarian cancer genes, such as BARD 1 gene, etc; (2) the homologous genes which were associated with other tumors, such as TM4SFI gene, etc; (3) the genes which were expressed in a special organization, such as ILF3, FXR1 gene, etc; (4) the genes which were the same with some protein genes of special function, such as TIZ, ClD gene; (5) the homologous genes which possessed the same source with embryonic genes, such as PKHD1 gene, etc; (6) the remaining genes were the unknown genes without the homologous sequence in the gene pool, such as OV-189 genes.
Fragile hearts: new insights into translational control in cardiac muscle.
Gregorio et al., Tucson, United States. In Trends Cardiovasc Med, 2013
New data have recently emerged, linking the RNA-binding protein FXR1 to the translation of key cytoskeletal components such as talin and desmoplakin in heart muscle.
FMRP targets distinct mRNA sequence elements to regulate protein expression.
Tuschl et al., New York City, United States. In Nature, 2013
Here we report the discovery of distinct RNA-recognition elements that correspond to the two independent RNA-binding domains of FMRP, in addition to the binding sites within the messenger RNA targets for wild-type and I304N mutant FMRP isoforms and the FMRP paralogues FXR1P and FXR2P (also known as FXR1 and FXR2).
FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124.
Gao et al., San Francisco, United States. In J Neurosci, 2011
FXR1P is required for efficient processing of pre-microR-9 and pre-microR-124 in vitro and forms a complex with Dicer and pre-miRNAs.
Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.
Gregorio et al., Tucson, United States. In Circ Res, 2011
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.
Murai et al., Montréal, Canada. In Plos One, 2010
FXR1P was highly expressed during hippocampal development and co-localized with ribosomes and mRNAs in the dendrite and at a subset of spines.
Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteins.
Nicholson et al., Bristol, United Kingdom. In Prog Retin Eye Res, 2010
These include tristetraprolin (TTP), T cell antigen-1 (TIA-1), TIA-1-related protein (TIAR), human antigen R (HuR) and fragile-X-related protein 1 (FXR1).
Fragile X-related protein FXR1 controls post-transcriptional suppression of lipopolysaccharide-induced tumour necrosis factor-alpha production by transforming growth factor-beta1.
Nicholson et al., Bristol, United Kingdom. In Febs J, 2010
Targeting the p38 mitogen-activated protein kinase pathway of LPS-treated cells with small molecule inhibitors can induce FXR1 protein expression.
Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Min et al., Toronto, Canada. In Plos One, 2009
Data show that the nuclear localization signals of the FXR1 and FXR2 comprise tandem Tudor domain architectures.
miRNPs: versatile regulators of gene expression in vertebrate cells.
Vasudevan et al., New Haven, United States. In Biochem Soc Trans, 2009
Under these conditions, called quiescence, the miRNP (microribonucleoprotein)-associated proteins FXR1 (Fragile X mental retardation-related protein 1) and AGO2 (Argonaute 2), which are usually considered negative regulators, are transformed into effector molecules that bind the ARE to activate translation.
Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway.
Ceman et al., Chicago, United States. In Rna Biol, 2009
The fragile X mental retardation protein family members, FMRP, FXR1P and FXR2P are RNA binding proteins that regulate translation of their cargo mRNAs.
Switching from repression to activation: microRNAs can up-regulate translation.
Steitz et al., New Haven, United States. In Science, 2008
Upon cell cycle arrest, the ARE in tumor necrosis factor-alpha (TNFalpha) mRNA is transformed into a translation activation signal, recruiting Argonaute (AGO) and fragile X mental retardation-related protein 1 (FXR1), factors associated with micro-ribonucleoproteins (microRNPs).
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.
Steitz et al., New Haven, United States. In Cell, 2007
A crosslinking-coupled affinity purification method was used to isolate TNF-alpha AU-rich element-associated proteins: two microRNP-related proteins, FXR1 and AGO2 were found that associate during translation activation.
Argonautes and company: sailing against the wind.
Filipowicz et al., Basel, Switzerland. In Cell, 2007
In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1--two proteins that have been linked to the regulation of microRNAs and translation repression.
Molecular phenotype of Fragile X syndrome: FMRP, FXRPs, and protein targets.
Ho et al., Baltimore, United States. In Microsc Res Tech, 2002
By immunoblotting, we found that a marked reduction in FMRP levels is associated with a modest increase in FXR1P and no changes in FXR2P levels.
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