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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Far upstream element

FUSE-binding protein, far upstream element-binding protein 1, FUBP1, HDH V, DNA helicase V
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: c-Myc, Cic, Id1, p53, Fir
Papers on FUSE-binding protein
Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing MYC Expression Levels.
Levens et al., Bethesda, United States. In Am J Pathol, Feb 2016
UNASSIGNED: The transcription factor far upstream element binding protein (FBP) binds the MYC promoter when far upstream element is melted.
The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas.
Louis et al., Bangkok, Thailand. In J Neuropathol Exp Neurol, Jan 2016
This review summarizes the current experience using immunohistochemistry of glioma samples to identify mutations in IDH1, TP53, ATRX, histone H3 genes, BRAF, EGFR, MGMT, CIC, and FUBP1 as well as guidelines for prudent use of DNA sequencing as a supplemental method.
ETV/Pea3 family transcription factor-encoding genes are overexpressed in CIC-mutant oligodendrogliomas.
Shirsat et al., Mumbai, India. In Genes Chromosomes Cancer, Dec 2015
Somatic mutations were found in the CIC and FUBP1 genes.
Far upstream element-binding protein 1 (FUBP1) is a potential c-Myc regulator in esophageal squamous cell carcinoma (ESCC) and its expression promotes ESCC progression.
Ji et al., Nantong, China. In Tumour Biol, Nov 2015
UNASSIGNED: The human far upstream element (FUSE) binding protein 1 (FUBP1) belongs to an ancient family which is required for proper regulation of the c-Myc proto-oncogene.
Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1.
Cairncross et al., Boston, United States. In Cns Oncol, Oct 2015
More recently, recurrent molecular genetic alterations have been identified to occur concurrently with 1p/19q-codeletion, and definitively identify these tumors, including mutations in IDH1/2, CIC, FUBP1, and the TERT promoter, as well as the absence of ATRX and TP53 alterations.
Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.
van den Bent et al., Paris, France. In Neuro Oncol, Oct 2015
We investigated a series of patients with locally diagnosed anaplastic oligodendroglial tumors included in the EORTC phase III trial 26951 on procarbazine/lomustine/vincristine (PCV) chemotherapy to explore the diagnostic, prognostic, and predictive value of targeted next-generation sequencing (NGS) in diffuse glioma and to assess the prognostic impact of FUBP1 and CIC mutations.
[Alternative Splicing Detection as a Biomarker for Cancer Diagnosis: A Novel Progressive Mechanism of Acute Lymphoblastic Leukemia with Alternative Splicing as a Biomarker Candidate].
Nomura et al., In Rinsho Byori, Sep 2015
FUSE-binding protein (FBP) -interacting repressor (FIR) is a transcriptional repressor of the c-myc gene.
Molecular Markers in Low-Grade Glioma-Toward Tumor Reclassification.
Sulman et al., Houston, United States. In Semin Radiat Oncol, Jul 2015
In this review, we discuss the effect of the most critical molecular alterations described in diffuse (IDH1/2, 1p/19q codeletion, ATRX, TERT, CIC, and FUBP1) and circumscribed (BRAF-KIAA1549, BRAF(V600E), and C11orf95-RELA fusion) gliomas.
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
Zhang et al., In N Engl J Med, Jul 2015
Their gliomas harbored mutations in CIC, FUBP1, NOTCH1, and the TERT promoter.
[Investigation of trichloroethylene-induced effects on subcellular proteomes in L-02 hepatic cells].
Liu et al., Guangzhou, China. In Zhonghua Yu Fang Yi Xue Za Zhi, Mar 2015
The expression of ATP synthase subunit beta (ATP5B), heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) and far up steam element-binding protein 1 (FUBP1) were measured under TCE treatment by Western blot.
[Alternative Splicing Detection as Biomarker Candidates for Cancer Diagnosis and Treatment with Establishment of Clinical Biobank in Chiba University].
Nomura et al., In Rinsho Byori, Mar 2015
FUSE-binding protein (FBP) -interacting repressor (FIR) is a c-myc transcriptional suppressor.
Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression.
Zeng et al., Guangzhou, China. In Cell Death Dis, 2014
Previous studies identified that far upstream element-binding protein 1 (FBP1), a transcriptional regulator of c-Myc that is one of the most frequently aberrantly expressed oncogenes in various human cancers, including NPC, is an important biomarker for many cancers.
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas.
Hartmann et al., Heidelberg, Germany. In Acta Neuropathol, 2012
Found CIC and FUBP1 mutations in oligodendrogliomas and demonstrate the presence of these mutations in oligoastrocytomas.
Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry site.
Miskimins et al., Sioux Falls, United States. In Int J Biochem Cell Biol, 2011
The central domain of FBP1, containing four K homology motifs, was required for p27 5'-UTR RNA binding and the N terminal domain was important for translational activation.
Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
Kinzler et al., Baltimore, United States. In Science, 2011
CIC gene was mutated in 6 oligodendrogliomas and FUBP1 gene was mutated in 2; 27 additional oligodendrogliomas showed 12 and 3 more tumors with mutations of CIC and FUBP1; results suggest role of these genes in biology and pathology of oligodendrocytes
USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1.
Dent et al., Anderson, United States. In Embo Rep, 2011
increased polyubiquitination of FBP1 does not alter its protein stability, but instead modulates the stable recruitment of FBP1 to target loci
FUSE binding protein 1 interacts with untranslated regions of Japanese encephalitis virus RNA and negatively regulates viral replication.
Lin et al., Taipei, Taiwan. In J Virol, 2011
The authors suggest that FUSE binding protein 1 binds with the Japanese encephalitis virus untranslated RNA and functions as a host anti-virus defense molecule by repressing viral protein expression.
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.
Kim et al., Seoul, South Korea. In Nat Genet, 2003
p38 was found to interact with FUSE-binding protein (FBP), a transcriptional activator of c-myc.
Structure and dynamics of KH domains from FBP bound to single-stranded DNA.
Clore et al., Bethesda, United States. In Nature, 2002
The KH domains of the FUSE-binding protein (FBP), a regulator of c-myc expression, bind in vivo and in vitro to the single-stranded far-upstream element (FUSE), 1,500 base pairs upstream from the c-myc promoter.
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