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Fucosyltransferase 1

fucosyltransferase, HSC, FUT1
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, Actin, ACID
Papers using fucosyltransferase antibodies
Targeting mTOR signaling in lung cancer.
Sherman Michael, In PLoS ONE, 2006
... N-CoR (C-20), PDI and Hsc-70 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.
Cheriyath Venugopalan, In PLoS ONE, 2005
... Polyclonal antibodies against CIB1 and HSC-70 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells.
Belkhiri Abbes, In PLoS ONE, 2002
BD Biosciences) and Hsc-70 (clone B6, Santa Cruz Biotechnology, Tebu-bio, Le Perray en ...
Evolutionary pattern of angiosperm bZIP factors homologous to the maize Opaque2 regulatory protein
Vincentz Michel GA et al., In BMC Evolutionary Biology, 2002
... Classification of α-fucosyltransferase PoGOs by taxonomic ranking and the complete list of gene IDs.
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Papers on fucosyltransferase
Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential.
Snoeck et al., New York City, United States. In Nature, Feb 2016
These findings provide a mechanism underlying clonal heterogeneity among HSCs and may lead to the design of approaches to bias HSC differentiation into desired lineages after transplantation.
Megakaryocyte and megakaryocyte precursor related gene therapies.
Wilcox, Milwaukee, United States. In Blood, Feb 2016
UNASSIGNED: Hematopoietic stem cells (HSC) can be safely collected from the body, genetically modified and re infused into a patient with the goal to express the transgene product for an individual's lifetime.
The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib.
Höchst et al., Bonn, Germany. In Cancer Immunol Immunother, Feb 2016
Our results indicate that sorafenib, nilotinib and dasatinib, but not sunitinib, decrease the HSC-mediated differentiation of monocytes into functional MDSCs.
Angiotensin II Regulation of Proliferation, Differentiation, and Engraftment of Hematopoietic Stem Cells.
Raizada et al., Gainesville, United States. In Hypertension, Feb 2016
This, coupled with the intimate involvement of the hyperactive renin-angiotensin system in hypertension, led us to investigate the hypothesis that chronic angiotensin II (Ang II) infusion affects hematopoietic stem cell (HSC) regulation at the level of the bone marrow.
Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.
Restifo et al., Bethesda, United States. In Cell Metab, Feb 2016
This metabolism-based approach to cell selection may be broadly applicable to therapies involving the transfer of HSC or lymphocytes for the treatment of viral-associated illnesses and cancer.
Dramatic Expansion of HSCs: New Possibilities for HSC Transplants?
Ritz et al., Boston, United States. In Cell Stem Cell, Feb 2016
The identification of mechanisms that regulate stem cell renewal has led to the development of innovative approaches to expand hematopoietic stem cells ex vivo.
Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma.
Naito et al., Tokyo, Japan. In Int J Oncol, Feb 2016
In human skin SCC cell lines, HSC-1 and HSC-5, and the human keratinocyte cell line, HaCaT, IMP3 mRNA levels were significantly higher than that of normal human skin.
Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy.
Medin et al., Toronto, Canada. In World J Stem Cells, Jan 2016
While some resounding clinical successes have recently been demonstrated, ample room remains to increase the therapeutic output from HSC-directed gene therapy.
Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact.
Bonnet et al., London, United Kingdom. In Expert Opin Biol Ther, Jan 2016
Despite an increase in our understanding of the different pathways regulated by HIF-1α and HIF-2α, the role played by each factor in HSC maintenance and leukemogenesis is still controversial.
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.
Li et al., Kansas City, United States. In Cell Stem Cell, Dec 2015
Through transcriptome profiling in 17 hematopoietic cell types, we found that ncRNAs expressed from the Dlk1-Gtl2 locus are predominantly enriched in fetal liver HSCs and the adult LT-HSC population and sustain long-term HSC functionality.
Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ.
Feldstein et al., San Diego, United States. In Cell Mol Gastroenterol Hepatol, Dec 2015
We investigated the role and molecular mechanism of extracellular vesicles (EVs) released by hepatocytes during lipotoxicity in modulation of HSC phenotype.
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
Morrison et al., Dallas, United States. In Nature, Nov 2015
We find that approximately 30% of α-catulin-GFP(+)c-kit(+) cells give long-term multilineage reconstitution of irradiated mice, indicating that α-catulin-GFP(+)c-kit(+) cells are comparable in HSC purity to cells obtained using the best markers currently available.
Maintenance of hematopoietic stem cell integrity and regulation of leukemogenesis by p53 and its coactivator Aspp1.
Suda et al., In Rinsho Ketsueki, 2014
Aspp1, an apoptosis-stimulating protein of p53, is highly expressed in HSCs and coordinates with p53 to maintain the genomic soundness of the HSC pool.
The Hematopoietic Niche in Myeloproliferative Neoplasms.
Zeiser et al., Freiburg, Germany. In Mediators Inflamm, 2014
The characterization of the cellular and molecular networks operating in the HSC niche has opened new perspectives for the understanding of the bidirectional cross-talk between HSCs and stromal cell populations in normal and malignant conditions.
Glucagon-like peptide-1 receptor agonists inhibit hepatic stellate cell activation by blocking the p38 MAPK signaling pathway.
Lu et al., Hangzhou, China. In Genet Mol Res, 2014
All cells were cultured for 120 h followed by detection of phosphorylated p38 MAPK (p-p38 MAPK) and α-smooth muscle actin (α-SMA, a measure of HSC activation) by western blot.
Macrophages regulate expression of α1,2-fucosyltransferase genes in human endometrial epithelial cells.
Robertson et al., Adelaide, Australia. In Mol Hum Reprod, 2012
Macrophage-derived factors including LIF might facilitate development of an implantation-receptive endometrium by regulating surface glycan structures in epithelial cells by up-regulating FUT1 and FUT2.
[Mutational analysis for FUT1 gene in two cases with para-Bombay blood type].
Zhao et al., Ningbo, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2011
FUT1 allele 547-548delAG deletion and 658C>T missense mutation in part form the molecular basis of para-Bombay blood types.
Molecular genetic analysis for the para-Bombay blood group revealing two novel alleles in the FUT1 gene.
Xiang et al., Shanghai, China. In Blood Transfus, 2011
In summary, two novel non-functional FUT1 alleles (FUT1 649T and FUT1 35T, 423A) were identifi ed in para-Bombay individuals
[Study on the expression stability of mutant alpha-1,2 fucosyltransferase gene 293C to T and 658C to T in eukaryotic cells].
Yan et al., Hangzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2011
mutations of FUT1 gene did not affect the RNA and protein expression levels, but the enzyme activity of cells with FUT1 mutations was significantly decreased which resulted in the reduced expressin of H antigen.
Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.
Kiyono et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
These results indicate that Fut2-mediated fucosylated epithelial cells (F-ECs) share M cell-related fucosylated molecules but maintain distinctive EC characteristics, Fut1 is, therefore, a reliable marker for M cells.
More papers using fucosyltransferase antibodies
Specificity of short interfering RNA determined through gene expression signatures
Mukhopadhyay Partha, In PLoS ONE, 2002
... Unlabeled negative control siRNA, 5′-carboxyfluorescein (FAM)-labelled negative control siRNA, GFP siRNA (GFP-22) and CXCR4 siRNA (HSC.RNAI.N001008540.12.1) were purchased from Ambion (Austin, TX), Shanghai GenePharma Co., Ltd (Shanghai, China) and Qiagen (Toronto, ON) and IDT ...
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