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Ferritin, light polypeptide

FTL, ferritin L subunit
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, apoferritin, HAD, ACID, Fos
Papers on FTL
Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.
Fernández-Real et al., Girona, Spain. In J Clin Endocrinol Metab, Feb 2016
Design, setting, patients and outcome measures: Markers of iron accumulation were measured in 3 different territories: Iron gene markers (TFRC1, TF, SLC11A2, FTL, FTH1 and SLC40A1) were studied in abdominal rectus abdominis (cohort 1, n=26) and quadriceps (cohort 2, n= 13) muscle using real time PCR, while paravertebral muscle R2* signal (as surrogate of iron content) (cohort 3, n=43) was evaluated by means of MRI.
AtRAV1 and AtRAV2 overexpression in cotton increases fiber length differentially under drought stress and delays flowering.
Rock et al., Lubbock, United States. In Plant Sci, Dec 2015
The transgenic AtRAV1 and AtRAV2 lines flowered later and retained bolls at higher nodes, which correlated with repression of endogenous GhFT-Like (FTL) transcript accumulation.
Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death.
Connor et al., Thailand. In Oncol Rep, Nov 2015
The impact of decreasing ferritin light chain (FTL) and ferritin heavy chain (FTH) expression on doxorubicin sensitivity was assessed using siRNA.
Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy.
Moingeon et al., Antony, France. In J Allergy Clin Immunol, Nov 2015
At an individual patient level, DC2-associated markers, such as CD141, GATA3, OX40 ligand, and receptor-interacting serine/threonine-protein kinase 4 (RIPK4), were downregulated after a 4-month sublingual AIT course concomitantly with an upregulation of DCreg cell-associated markers, including complement C1q subcomponent subunit A (C1QA), FcγRIIIA, ferritin light chain (FTL), and solute carrier organic anion transporter family member 2B1 (SLCO2B1), in the blood of clinical responders as opposed to nonresponders.
Voxel-based analysis in neuroferritinopathy expands the phenotype and determines radiological correlates of disease severity.
Blamire et al., Newcastle upon Tyne, United Kingdom. In J Neurol, Oct 2015
Neuroferritinopathy is an autosomal dominant adult-onset movement disorder which occurs due to mutations in the ferritin light chain gene (FTL).
Exome Sequencing and Epigenetic Analysis of Twins Who Are Discordant for Congenital Cataract.
Yan et al., Wuhan, China. In Twin Res Hum Genet, Aug 2015
METHODS: A patient with a congenital cataract and her twin sister were assessed for genetic factors that might contribute to their discordant phenotypes by mutation screening of 11 candidate genes (CRYGC, CRYGD, CRYAA, CRYAB, CRYBA1, CRYBB1, CRYBB2, MIP, HSF4, GJA3, and GJA8), exome analysis followed by Sanger sequencing of 10 additional candidate genes (PLEKHO2, FRYL, RBP3, P2RX2, GSR, TRAM1, VEGFA, NARS2, CADPS, and TEKT4), and promoter methylation analysis of five representative genes (TRAM1, CRYAA, HSF4, VEGFA, GJA3, DCT) plus one additional candidate gene (FTL).
Tracking the fear memory engram: discrete populations of neurons within amygdala, hypothalamus, and lateral septum are specifically activated by auditory fear conditioning.
Murphy et al., Melbourne, Australia. In Learn Mem, Aug 2015
We have previously used fos-tau-lacZ (FTL) transgenic mice to identify discrete populations of neurons in amygdala and hypothalamus, which were specifically activated by fear conditioning to a context.
Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.
Wray et al., London, United Kingdom. In Neuropathol Appl Neurobiol, May 2015
Mutations in 10 genes have been associated with NBIA that include Ceruloplasmin (Cp) and ferritin light chain (FTL), both directly involved in iron homeostasis, as well as Pantothenate Kinase 2 (PANK2), Phospholipase A2 group 6 (PLA2G6), Fatty acid hydroxylase 2 (FA2H), Coenzyme A synthase (COASY), C19orf12, WDR45 and DCAF17 (C2orf37).
Inner retinal change in a novel rd1-FTL mouse model of retinal degeneration.
Fletcher et al., Melbourne, Australia. In Front Cell Neurosci, 2014
In this study, the rd1-Fos-Tau-LacZ (rd1-FTL) mouse model was used to explore inner retinal change at a late stage of retinal degeneration, after the loss of photoreceptor nuclei.
Morphogenesis, Flowering, and Gene Expression of Dendranthema grandiflorum in Response to Shift in Light Quality of Night Interruption.
Jeong et al., Chinju, South Korea. In Int J Mol Sci, 2014
The transcriptional factors phyA, cry1 and FTL (FLOWERING LOCUS T) were positively affected, while phyB and AFT were negatively affected.
The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.
Yeo, Cambridge, United Kingdom. In Mol Cell Endocrinol, 2014
Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity.
Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms.
Finazzi et al., Milano, Italy. In Front Pharmacol, 2013
Two forms are linked to mutations in genes directly involved in iron metabolism: neuroferritinopathy, associated to mutations in the FTL gene and aceruloplasminemia, where the ceruloplasmin gene product is defective.
Neurodegeneration with Brain Iron Accumulation Disorders Overview
Hayflick et al., Seattle, United States. In Unknown Journal, 2013
The ten genes known to be associated with types of NBIA are PANK2, PLA2G6, C19orf12, FA2H, ATP13A2, WDR45, COASY, FTL, CP, and DCAF17.
The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise.
Liu et al., Beijing, China. In Biol Trace Elem Res, 2012
Data suggest that soluble transferrin receptor (sTfR) indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training.
A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage.
Vidal et al., Indianapolis, United States. In Free Radic Biol Med, 2012
data demonstrate an enhanced propensity of mutant ferritin to undergo iron-catalyzed oxidative damage and support this as a mechanism causing disruption of ferritin structure and iron mishandling that contribute to pathology of hereditary ferritinopathy
Two novel mutations in the L ferritin coding sequence associated with benign hyperferritinaemia unmasked by glycosylated ferritin assay.
Grandchamp et al., Farnborough, United Kingdom. In Ann Clin Biochem, 2012
Two novel missense L-ferritin variants are associated with hyperglycosylation, p.Gln26Ile and p.Ala27Val, and with benign hyperferritinemia in two unrelated patients.
Pretransplant serum ferritin level may be a predictive marker for outcomes in patients having undergone allogeneic hematopoietic stem cell transplantation.
Eser et al., Kayseri, Turkey. In Neoplasma, 2011
High ferritin is associated with poor treatment response in hematological neoplasms.
Ferritin light chain and squamous cell carcinoma antigen 1 are coreceptors for cellular attachment and entry of hepatitis B virus.
Huang et al., Shanghai, China. In Int J Nanomedicine, 2011
The data strongly suggest that FTL and SCCA1 may serve as coreceptors in HBV cellular attachment and virus entry into hepatocytes.
Bimodal lentiviral vector encoding myc-tagged human ferritin heavy chain and green fluorescent protein (GFP)
Shan, Bethesda, United States. In Unknown Journal, 2011
Ferritin is a globular protein that consists of two subunits, heavy chain (FTH) and light chain (FTL).
Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease.
Burn et al., Newcastle upon Tyne, United Kingdom. In Nat Genet, 2001
We mapped the disorder, by linkage analysis, to 19q13.3, which contains the gene for ferritin light polypeptide (FTL).
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