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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cell death-inducing DFFA-like effector c

FSP27, Cidec, Fat specific protein 27, Cell Death-inducing DFFA-like Effector C
This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Insulin, ACID, ICAD, CIDEA, CAN
Papers on FSP27
Differential Roles of CIDE Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes.
Zhou et al., Taiwan. In J Biol Chem, Feb 2016
CIDE proteins including Cidea, Cideb and Cidec (also called Fsp27) play important roles in lipid metabolism.
Modulation Effect of Peroxisome Proliferator-Activated Receptor Agonists on Lipid Droplet Proteins in Liver.
Jia et al., Shanghai, China. In J Diabetes Res, Dec 2015
The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with hepatic steatosis and insulin sensitivity.
Microarray Analysis Reveals Altered Lipid and Glucose Metabolism Genes in Differentiated, Ritonavir-Treated 3T3-L1 Adipocytes.
Mullen et al., London, United Kingdom. In Curr Hiv Res, Dec 2015
Cidec (73.75-fold) and Pparg (5.63-fold).
Cidec promotes the differentiation of human adipocytes by degradation of AMPKα through ubiquitin-proteasome pathway.
Li et al., Xi'an, China. In Biochim Biophys Acta, Dec 2015
BACKGROUND: We previously showed that Cidec was localized on the surface of lipid droplets and could promote the differentiation of human adipocytes, but the molecular mechanism was still unknown.
Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.
Westendorf et al., Rochester, United States. In J Bone Miner Res, Aug 2015
Hdac3-deficient cultures accumulated lipid droplets in greater abundance than control cultures and expressed high levels of genes related to lipid storage (Fsp27/Cidec, Plin1) and glucocorticoid metabolism (Hsd11b1) despite normal levels of Pparγ2.
Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle.
Chen et al., China. In Sci Rep, 2014
Cell death-inducing DFFA-like effector c (CIDEC, also known as Fsp27) has emerged as an important regulator of metabolism associated with lipodystrophy, diabetes, and hepatic steatosis.
Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice.
Puri et al., Boston, United States. In Plos One, 2014
Cidea and Cidec play an important role in regulating triglyceride storage in liver and adipose tissue.
Polymorphisms in the bovine CIDEC gene are associated with body measurement traits and meat quality traits in Qinchuan cattle.
Zan et al., China. In Genet Mol Res, 2014
Previous studies have shown that the cell death-inducing DFF45-like effector-C (CIDEC) gene is involved in lipid storage and energy metabolism, suggesting that it is a potential candidate gene that affects body measurement traits (BMTs) and meat quality traits (MQTs).
Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver.
Sladek et al., Riverside, United States. In Plos One, 2014
Other genes involved in obesity (e.g., Cidec, Cd36), diabetes (Igfbp1), inflammation (Cd63), mitochondrial function (Pdk4) and cancer (H19) were also upregulated by the soybean oil diet.
Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.
Nolis, Canada. In J Hum Genet, 2014
In the acquired forms, genes such as LMNA, PPARG, CIDEC (cell-death-inducing DNA fragmentation factor a-like effector c) and PLIN1 are heavily involved in familial partial lipodystrophy (FPLD) type 2 (also known as the Dunnigan-Variety) and WRN along with RECQL5 in Werner Syndrome (WS).
[Research advances on CIDEC in insulin resistance].
Xiao et al., Xi'an, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2013
Recent studies have indicated that cell death-inducing DFF45-like effector C (CIDEC) is responsible for the development of insulin resistance.
Nuclear receptor-mediated regulation of lipid droplet-associated protein gene expression in adipose tissue.
Christian, Coventry, United Kingdom. In Horm Mol Biol Clin Investig, 2013
Of these genes, the greatest PPARγ binding was to regulatory regions for Plin1, Cidec, and G0s2.
How to diagnose a lipodystrophy syndrome.
Wémeau et al., Lille, France. In Ann Endocrinol (paris), 2012
Gene mutations encoding for PPAR-gamma, Akt2, CIDEC, perilipin and the ZMPSTE 24 enzyme are much more rare.
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites.
Li et al., Beijing, China. In J Cell Biol, 2012
A novel molecular mechanism of lipid droplet growth mediated by Fsp27 was uncovered.
[Novel mechanism for hepatic lipid accumulation: a physiological role for hepatic PPARγ-fsp27 signal].
Matsusue, Fukuoka, Japan. In Yakugaku Zasshi, 2011
Fat-specific protein 27 (fsp27) was originally isolated by screening for genes specifically expressed in fully differentiated mouse adipocytes.
Human cell-death-inducing DFF45-like effector C induces apoptosis via caspase-8.
Zhao et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2011
Results demonstrated that CIDEC-induced apoptosis was independent of FADD, suggesting that CIDEC-induced apoptosis might be in a death-receptor-independent, caspase-8-dependent manner.
Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes.
Murakami et al., Tochigi, Japan. In J Lipid Res, 2011
Insulin regulates CIDEA and CIDEC expression via PI3K, and it regulates expression of each protein via Akt1/2-and JNK2-dependent pathways, respectively, in human adipocytes.
Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27.
Bennett et al., New Haven, United States. In J Biol Chem, 2011
MKP-1 plays an important role in MAPK-mediated control of hepatic lipid homeostasis
Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype.
Koike et al., Sapporo, Japan. In Plos One, 2009
Findings demonstrate that overexpression of PeriA in white adipocytes reduces lipid droplet size by decreasing FSP27 expression and thereby inducing a brown adipose tissue-like phenotype.
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.
Gonzalez et al., Bethesda, United States. In Cell Metab, 2008
FSP27 is a direct mediator of PPARgamma-dependent hepatic steatosis.
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