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Fascin homolog 2, actin-bundling protein, retinal

FSCN2, RP-30, Retinal fascin, Fascin 2
This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Fascin, HAD, ADRP, Actin, ACID
Papers on FSCN2
[Genotype-phenotype correlation in patients with PRPH2-mutations].
Rudolph et al., Tübingen, Germany. In Klin Monbl Augenheilkd, Mar 2015
Blood samples were taken for DNA extraction and mutation analysis of PRPH2 and ABCA4, BEST1, C1QTNF5, CDH3, CNGB3, ELOVL4, FSCN2, PROM1, RDH12, RP1L1, RPGR, TIMP3 was performed.
Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector.
van den Pol et al., New Haven, United States. In Virology, Feb 2015
We compared 12 antiviral compounds to control infection of VSV-CT9-M51 and VSV-rp30 using murine and human brain cultures, and in vivo mouse models.
Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice.
Kikkawa et al., Tokyo, Japan. In Exp Anim, 2014
It is known that the early-onset hearing loss of DBA/2J mice is caused by affects in the ahl (Cdh23(ahl)) and ahl8 (Fscn2(ahl8)) alleles of the cadherin 23 and fascin 2 genes, respectively.
Whole exome sequencing in Thai patients with retinitis pigmentosa reveals novel mutations in six genes.
Atchaneeyasakul et al., Bangkok, Thailand. In Invest Ophthalmol Vis Sci, 2014
In addition, two patients carried variants of uncertain significance in genes FSCN2 and NR2E3.
Correlation of actin crosslinker and capper expression levels with stereocilia growth phases.
Barr-Gillespie et al., Portland, United States. In Mol Cell Proteomics, 2014
fascins, plastins, and espin) are expressed dynamically during cochlear epithelium development between E7 and E21, with FSCN2 replacing FSCN1 and plastins remaining low in abundance.
Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes.
van den Pol et al., New Haven, United States. In J Virol, 2013
Several recombinant VSVs were compared, and all infected and killed most melanomas with differences in the time course with increasing rates of melanoma infection, as follows: VSV-CT9-M51 < VSV-M51 < VSV-G/GFP < VSV-rp30.
Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization.
Antonacci et al., Bahrain. In Rapid Commun Mass Spectrom, 2013
biomass, produced in closed photobioreactors, was determined by reversed-phase C30 (RP-30) high-performance liquid chromatography coupled with diode-array detector mass spectrometry using positive electrospray ionization (HPLC/DAD-MS/ESI(+) ) analysis.
Modulation of monocyte chemoattractant protein-1 expression by ischaemic preconditioning in a lung autotransplant model.
González-Aragoneses et al., Madrid, Spain. In Eur J Cardiothorac Surg, 2012
Blood samples and lung biopsies were obtained at prepneumonectomy (PPn), at prereperfusion (PRp) and up to 30 min after reperfusion of the implanted lobe (Rp-10' and Rp-30').
The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin.
Hoffmann et al., Jülich, Germany. In Cell Adh Migr, 2011
The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin
Simultaneous HPLC-DAD-MS (ESI+) determination of structural and geometrical isomers of carotenoids in mature grapes.
Antonacci et al., Casamassima, Italy. In J Mass Spectrom, 2010
Carotenoid compounds in a typical wine grape variety (Negroamaro) grown in Apulian region were investigated by reversed-phase C(30) (RP-30) HPLC-DAD-MS (ESI(+)) analysis.
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.
Johnson et al., Portland, United States. In J Neurosci, 2010
A nonsynonymous nucleotide substitution in the mouse fascin-2 gene (Fscn2) is responsible for this phenotype, confirmed by wild-type BAC transgene rescue of hearing loss in DBA/2J mice.
Fascin expression predicts survival after potentially curative resection of node-positive colon cancer.
Clarke et al., Sydney, Australia. In Am J Surg Pathol, 2010
Fascin expression predicts survival after potentially curative resection of node-positive colon cancer.
Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells.
van den Pol et al., New Haven, United States. In J Virol, 2010
In the first group, wild-type-based VSV-G/GFP, tumor-adapted VSV-rp30, and VSV-CT9 showed a strong antitumor profile but also retained some toxicity toward noncancer control cells.
Effects of small interfering RNAs targeting Fascin on gene expression in oral cancer cells.
Nieh et al., Taiwan. In J Oral Pathol Med, 2009
expression may play an essential role in regulation of progression of oral squamous cell carcinoma and contributes to the event of epithelial-mesenchymal transition in the early aggressiveness of OSCC
Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma.
Jin et al., Taiwan. In Dis Esophagus, 2008
Higher fascin scores correlated positively with tumor differentiation of esophageal SqCC. Significantly worse prognosis in patients with high scores of fascin, poor differentiation, T4 stage, positive for lymph node metastasis and distant metastasis
[Genetic aspects of age-related macular degeneration].
Błasiak et al., In Klin Oczna, 2008
The results of some research indicate that the genes, which products may play a role in the pathogenesis of AMD could be CFB, C2, CFHR1, CFHR3, C3, ABCR, APOE, CCL2, CFH, CX3CR1, ERCC6, FSCN2, HMCN1, HTRA1, LOC387715, PLEKHA1, TIMP3 and VEGF-A.
Allelic copy number variation in FSCN2 detected using allele-specific genotyping and multiplex real-time PCRs.
Takahashi et al., Kōbe, Japan. In Invest Ophthalmol Vis Sci, 2008
Real-time PCR-based genotyping method developed here is useful for investigations of allelic asymmetries within genomic regions with variations found in retinitis pigmentosa and retinl degeneration.
Fascin in ovarian epithelial tumors.
Koukoulis et al., Lárisa, Greece. In Histol Histopathol, 2008
In ovarian tumors fascin is associated with certain features of increased tumor aggressiveness.
A high-resolution RNA expression atlas of retinitis pigmentosa genes in human and mouse retinas.
Marigo et al., Napoli, Italy. In Invest Ophthalmol Vis Sci, 2008
Different expression patterns were observed for the CNGB1, USH2A, and FSCN2 genes, compared with those in previously reported profiles.
Reactivity of synthetic SAG1 (p30) peptide sequences with RH, S273 and Beverley strain-induced anti-Toxoplasma gondii antibodies.
Suzuki et al., Obihiro, Japan. In Pathobiology, 2006
OBJECTIVES: We compared the reactivity of IgG1 and IgG2a antibodies in mouse sera after infection with virulent RH and low-virulent S273 and Beverley strains of Toxoplasma gondii against RH SAG1 recombinant p30 (rp30) and synthetic SAG1 peptides.
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