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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

FERM, RhoGEF and pleckstrin domain protein 2

This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, OUT, Cdc42
Papers using FRG antibodies
Effects of interferon-gamma 1b on biomarker expression in patients with idiopathic pulmonary fibrosis
Zissel Gernot et al., In Respiratory Research, 2003
... pyruvate from Biochrom (Berlin, FRG); trypsin/EDTA solution from Boehringer-Mannheim (Mannheim, FRG); collagen R from Serva (Heidelberg, FRG); chloroform and isopropanol from Merck (Darmstadt, FRG); recombinant human ...
Papers on FRG
Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model.
Cosset et al., Lyon, France. In J Biol Chem, Oct 2015
Sera from HCVcc-infected liver humanized FRG mice were separated by density gradients.
Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy.
Kang et al., Beijing, China. In Chin J Integr Med, Aug 2015
OBJECTIVE: To investigate the adjuvant therapeutic effects of fermented red ginseng (FRG) extract on non-small cell lung cancer (NSCLC) patients treated with chemotherapy.
Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice.
Kappe et al., Seattle, United States. In Cell Host Microbe, May 2015
To overcome this obstacle, we have used human liver-chimeric (huHep) FRG KO mice as a model for P. vivax infection.
Hepatoprotective effect of fermented ginseng and its major constituent compound K in a rat model of paracetamol (acetaminophen)-induced liver injury.
Kashiwada et al., Kōbe, Japan. In J Pharm Pharmacol, Apr 2015
OBJECTIVES: This work aimed at evaluating the effect of fermented ginseng (FG) and fermented red ginseng (FRG) against rat liver injury caused by paracetamol (acetaminophen (APAP)).
Novel SLC5A2 variants contribute to renal glucosuria in Chinese families: abnormal expression and dysfunction of variant SLC5A2.
Zhang et al., Hohhot, China. In Hum Mutat, 2015
Familial renal glucosuria (FRG) is characterized by persistent glucosuria despite normal serum glucose and the absence of overt tubular dysfunction.
Determination of the renal threshold for glucose excretion in Familial Renal Glucosuria.
Calado et al., Lisbon, Portugal. In Nephron, 2014
BACKGROUND/AIMS: Familial Renal Glucosuria (FRG) is characterized by the presence of persistent isolated glucosuria in the absence of hyperglycemia.
HBV whole-genome mutation profile in HIV-1/HBV coinfected patients in a long-term follow-up study.
Rapicetta et al., Roma, Italy. In Infection, 2014
METHODS: HIV-1 and HBV markers determinations (Roche, FRG; Abbott, USA) and HBV genome-length retrospective analysis were performed in follow-up isolates from patients who were either stably HBsAg-negative with a low level of HBV DNA (occult hepatitis B infection, OBI) or HBsAg-positive with a high level of HBV DNA.
In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling.
O'Shaughnessy et al., In Hum Reprod, 2014
212885, a Society for Reproduction & Fertility summer studentship, Medical Research Scotland (research grant 354 FRG) and the Medical Research Council (WBS: U.1276.00.002.00001 and G1100357).
Hypouricaemia and hyperuricosuria in familial renal glucosuria.
Calado et al., Lisbon, Portugal. In Clin Kidney J, 2013
We report a case of FRG displaying both severe glucosuria and renal hypouricaemia.
Effect of kidney disease on glucose handling (including genetic defects).
Rueff et al., Lisbon, Portugal. In Kidney Int Suppl, 2011
Mutations in SLC5A2, the SGLT2 coding gene, are responsible for familial renal glucosuria (FRG), a genetic disorder characterized by glucosuria in the absence of both hyperglycemia and generalized proximal tubular dysfunction.
Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.
Northrup et al., Houston, United States. In Birth Defects Res A Clin Mol Teratol, 2010
The rare alleles of specific single nucleotide polymorphisms within the FOLR1, FOLR2, and FOLR3 genes were statistically significant for association with meningomyelocele.
Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.
Calado et al., Lisbon, Portugal. In Clin J Am Soc Nephrol, 2010
Mutations in SGLT1 are associated with glucose-galactose malabsorption, SGLT2 with familial renal glucosuria (FRG), and GLUT2 with Fanconi-Bickel syndrome.
Glucose control by the kidney: an emerging target in diabetes.
Marsenic, Philadelphia, United States. In Am J Kidney Dis, 2009
The glucosuria induced by these compounds has a naturally occurring parallel in familial renal glucosuria (FRG), a condition in which SGLT2 mutations reduce renal reabsorptive capacity.
Frabin and other related Cdc42-specific guanine nucleotide exchange factors couple the actin cytoskeleton with the plasma membrane.
Takai et al., Kumamoto, Japan. In J Cell Mol Med, 2008
Frabin, together with, at least, FGD1, FGD2, FGD3 and FGD1-related Cdc42-GEF (FRG), is a member of a family of Cdc42-specific gua-nine nucleotide exchange factors (GEFs).
Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.
Itoh et al., Ikoma, Japan. In J Biol Chem, 2003
FRG is a member of Cdc42-GEF and plays an important role in the signaling pathway downstream of G protein-coupled receptors
Structure in solution of the major cold-shock protein from Bacillus subtilis.
Holak et al., München, Germany. In Nature, 1993
The same domain exists in the sequence of the Xenopus RNA-binding proteins FRG Y1 and FRG Y2 (refs 1, 3).
[Exogenous harmful substances in pregnancy and their effects on the embryo and fetus].
Fabel, In Zentralbl Gynakol, 1987
Malformations observed at birth or immediately afterwards happen according to the definition with a frequency of 2 to 4% (FRG), according to sources from other countries with a frequency of 2.5 to 6.5%.
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