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FOS-like antigen 1

Fra-1, FRA
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AP-1, Fos, CAN, V1a, HAD
Papers on Fra-1
HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells.
Yuan et al., Guangzhou, China. In Oncotarget, Jan 2016
We report here that HDACIs including trichostatin A, suberoylanilidehydroxamic acid, valproic acid and M344 can transcriptionally suppress both c-Jun and Fra-1, preceding their inhibition of cell growth.
Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.
Peeper et al., Amsterdam, Netherlands. In Oncotarget, Jan 2016
Fra-1 (Fos-related antigen-1) is a member of the AP-1 (activator protein-1) family of transcription factors.
The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.
von Amsberg et al., Hamburg, Germany. In Int J Cancer, Jan 2016
We investigated efficacy, toxicity and mechanism of action of marine triterpene glycoside frondoside A (FrA) using CRPC cell lines in vitro and in vivo.
Endoplasmic reticulum stress in the brain subfornical organ contributes to sex differences in angiotensin-dependent hypertension in rats.
Peng et al., Shenyang, China. In Acta Physiol (oxf), Jan 2016
Molecular studies revealed that ANG II elevated expression of ER stress biomarkers and Fra-like activity in the SFO in both males and females; however, elevations in these parameters were less in intact females than in males or OVX females.
Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex.
Geller et al., Pittsburgh, United States. In Plos One, Dec 2015
Furthermore, our ChIP analysis demonstrated that p300 was binding to Jun D and Fra-2 proteins at -5.3 kb AP-1 binding site in vivo.
FRA-1 as a driver of tumour heterogeneity: a nexus between oncogenes and embryonic signalling pathways in cancer.
Tulchinsky et al., Melbourne, Australia. In Oncogene, Sep 2015
In this review, we examine a growing body of work implicating the transcription factor FOS-related antigen 1 (FRA-1) as a central node in tumour cell plasticity networks, and discuss mechanisms regulating its activity in cancer cells.
Therapy-induced tumour secretomes promote resistance and tumour progression.
Massagué et al., New York City, United States. In Nature, May 2015
The tumour-promoting secretome of melanoma cells treated with the kinase inhibitor vemurafenib is driven by downregulation of the transcription factor FRA1.
A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer.
Wang et al., Jinan, China. In Drug Des Devel Ther, 2014
Folate receptor alpha (FRA) is overexpressed in the majority of NSCLC, particularly in lung adenocarcinomas.
Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers.
Wagner et al., Spain. In Cell Metab, 2014
Fos-related antigen 1 (Fra-1) and Fos-related antigen 2 (Fra-2) prevent dietary NAFLD by inhibiting prosteatotic PPARγ signaling.
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells.
Weinberg et al., Cambridge, United States. In Cancer Cell, 2013
The formation of CSCs from non-stem cells involves a shift from EGFR to PDGFR signaling and results in the PKCα-dependent activation of FRA1.
Stress-triggered changes in peripheral catecholaminergic systems.
Ziegler et al., Bratislava, Slovakia. In Adv Pharmacol, 2012
However, repeated stress gives a longer-lived response utilizing transcription factors such as Egr-1 and Fra-2.
The tumor microenvironment: a target for combination therapy of breast cancer.
Reisfeld, Los Angeles, United States. In Crit Rev Oncog, 2012
Particular emphasis is placed on targeting such components of the TME as tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) overexpressing specific therapy targets such as Legumain, an asparaginyl endopeptidase, proto-oncogene Fra-1, transcription factor Stat3 and fibroblast activation protein (FAP) as well as HER-2, respectively.
Estrogen-induced expression of Fos-related antigen 1 (FRA-1) regulates uterine stromal differentiation and remodeling.
Bagchi et al., Urbana, United States. In J Biol Chem, 2012
FRA-1, induced in response to estrogen signaling via ESR1, is a key regulator of stromal differentiation and remodeling during early pregnancy.
Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9.
Chang et al., Tainan City, Taiwan. In J Virol, 2012
Fra-1 was induced by Epstein-Barr virus LMP2A and is essential for LMP2A-triggered MMP9 expression.
Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone.
Leigh et al., Calgary, Canada. In J Immunol, 2012
Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone.
FOSL1 as a candidate target gene for 11q12 rearrangements in desmoplastic fibroblastoma.
Nord et al., Lund, Sweden. In Lab Invest, 2012
the molecular data suggest that the functional outcome of the 11q12 rearrangements is deregulated expression of FOSL1.
Effects of expression of transcriptional factor AP-1 FOSL1 gene on psoriatic process.
Piruzyan et al., Moscow, Russia. In Bull Exp Biol Med, 2011
Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index. High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.
Inhibition of osteoblastic bone formation by nuclear factor-kappaB.
Wang et al., Los Angeles, United States. In Nat Med, 2009
Inhibition of IKK-NF-kappaB enhances the expression of Fos-related antigen-1 (Fra-1), an essential transcription factor involved in bone matrix formation in vitro and in vivo.
A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance.
Bashaw et al., Philadelphia, United States. In Science, 2009
Here, we show that the Fra receptor has two genetically separable functions in regulating midline guidance in Drosophila.
Neuronal expression of AP-1 proteins in excitotoxic-neurodegenerative disorders and following nerve fiber lesions.
Herdegen et al., Heidelberg, Germany. In Prog Neurobiol, 1995
This review tries to survey the expression patterns of inducible transcription factors (ITFs) of the Jun (c-Jun, JunB, JunD) and Fos (c-Fos, FosB, Fra) families as well as of zinc finger proteins (Krox-20 and Krox-24) and their mRNAs following ischemia, epileptic seizures, hypoglycemia, axotomy and(programmed) neuronal death in the mammalian brain.
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