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Forkhead box P4

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FOXP1, FOXP2, Foxp3, HAD, MEN
Papers on Foxp4
Identification of differentially methylated regions in new genes associated with knee osteoarthritis.
Westendorf et al., Rochester, United States. In Gene, Feb 2016
In particular, this approach uncovered promising candidates for functional studies such as the hypermethylated protein-coding genes FOXP4 and SHROOM1, which appear to be linked to OA pathology in humans and warrant further investigation.
Association of THADA, FOXP4, GPRC6A/RFX6 genes and 8q24 risk alleles with prostate cancer in Northern Chinese men.
Yang et al., Yinchuan, China. In J Buon, Sep 2015
CONCLUSION: Our results provide further support for association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with Pca in Asian populations.
FOXP4 modulates tumor growth and independently associates with miR-138 in non-small cell lung cancer cells.
Chen et al., Xi'an, China. In Tumour Biol, Sep 2015
Family of forkhead box transcription factors, including forkhead box P4 (FOXP4), plays an important role in oncogenesis.
The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.
Stein et al., Nashville, United States. In Diabetologia, Aug 2015
In this study we have examined the importance of FOXP1, FOXP2 and FOXP4 of the FOXP subfamily in islet cell development and function.
Differential coexpression of FoxP1, FoxP2, and FoxP4 in the Zebra Finch (Taeniopygia guttata) song system.
Scharff et al., Berlin, Germany. In J Comp Neurol, Jul 2015
In vitro, transcriptional activity of FoxP2 requires dimerization with itself or with paralogs FoxP1 and FoxP4.
Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization.
Crawford et al., Toronto, Canada. In J Mol Neurosci, Feb 2015
FOXP1, FOXP2, and FOXP4 are three members of the FOXP gene subfamily of transcription factors involved in the development of the central nervous system.
Association of FOXP4 Gene with Prostate Cancer and the Cumulative Effects of rs4714476 and 8q24 in Chinese Men.
Yang et al., In Clin Lab, 2014
BACKGROUND: The tumor suppressor forkhead box P4 (FOXP4) plays important roles in oncogenesis, and the FOXP4 variant rs1983891 is associated with prostate cancer (PCa) in several studies.
MicroRNA-338-3p inhibits cell proliferation in hepatocellular carcinoma by target forkhead box P4 (FOXP4).
Sun et al., Jinan, China. In Int J Clin Exp Pathol, 2014
Using bio-informatic method and report assay we identified a novel miR-338-3p target, FOXP4 in HCC cells.
Susceptibility loci associations with prostate cancer risk in northern Chinese men.
Wang et al., Beijing, China. In Asian Pac J Cancer Prev, 2012
G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays important roles in the development of PCa.
A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.
Reik et al., In Genome Biol, 2012
Only a few proteins were identified with a preference for 5hmC (such as RPL26, PRP8 and the DNA mismatch repair protein MHS6), but proteins with a strong preference for 5fC were more numerous, including transcriptional regulators (FOXK1, FOXK2, FOXP1, FOXP4 and FOXI3), DNA repair factors (TDG and MPG) and chromatin regulators (EHMT1, L3MBTL2 and all components of the NuRD complex).
Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.
Morrisey et al., Philadelphia, United States. In Development, 2012
Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2).
Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.
Novitch et al., Los Angeles, United States. In Neuron, 2012
the data of this study revealed a Foxp-based transcriptional mechanism that regulates the integrity and cytoarchitecture of neuroepithelial progenitors
Foxp4 is dispensable for T cell development, but required for robust recall responses.
Maltzman et al., Philadelphia, United States. In Plos One, 2011
Foxp4, an additional member of the Foxp family, is highly homologous to Foxp1 and has been shown to dimerize with other Foxp proteins.
The role of the FOXP family of transcription factors in ASD.
Konopka et al., Dallas, United States. In Dis Markers, 2011
The FOXP family of genes includes three genes expressed in the central nervous system: FOXP1, FOPX2, and FOXP4.
Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum.
Kwan et al., Hong Kong, Hong Kong. In Neuroscience, 2011
Foxp4 is dispensable for the early Purkinje cell (PC) dendrite outgrowth but is essential for the maintenance of PC dendritic arborization and subsequent association with Bergmann glial fibers.
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
Nakagawa et al., Tokyo, Japan. In Nat Genet, 2010
In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)).
Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.
Morrisey et al., Philadelphia, United States. In J Biol Chem, 2010
Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.
Expression of Foxp4 in the developing and adult rat forebrain.
Takahashi et al., Tokyo, Japan. In J Neurosci Res, 2008
Foxp4 was developmentally down-regulated such that Foxp4 was undetectable in the forebrain after postnatal day 14
Human FOX gene family (Review).
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
Advanced cardiac morphogenesis does not require heart tube fusion.
Morrisey et al., Philadelphia, United States. In Science, 2004
We present evidence that, in Foxp4 mutant embryonic mice, each bilateral heart-forming region is capable of developing into a highly differentiated four-chambered mammalian heart in the absence of midline fusion.
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