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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Forkhead box O6

Top mentioned proteins: FOXO1, FOXO3a, FOXO4, V1a, Insulin
Papers on FoxO6
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.
Link et al., Faro, Portugal. In Aging Cell, Jan 2016
Invertebrate genomes have one FOXO gene, while mammals have four FOXO genes: FOXO1, FOXO3, FOXO4, and FOXO6.
Suppression of FoxO6 by lipopolysaccharide in aged rat liver.
Chung et al., Pusan, South Korea. In Oncotarget, Nov 2015
However, the correlation between FoxO6 and NF-κB during aging has not fully been explored.The main purpose of the present study was to elucidate mechanisms underlying the protective role of FoxO6 in the maintenance of cellular homeostasis under potent pro-inflammatory conditions induced by LPS.
FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.
Guo et al., Xinxiang, China. In Mol Med Report, Jul 2015
The present study demonstrated that the expression levels of forkhead box O6 (FOXO6) were downregulated in lung cancer tissue samples, as compared with those in adjacent normal tissue.
Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice.
Dong et al., Sapporo, Japan. In J Biol Chem, Jul 2015
FoxO6 is a distinct member of the FoxO subfamily.
Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways.
Haber et al., United States. In Elife, 2014
We show that erlotinib relieves EGFR-dependent suppression of FOXO6, leading to its induction of SOX2, which in turn represses the pro-apoptotic BH3-only genes BIM and BMF.
FoxO3a and disease progression.
Hergert et al., Minneapolis, United States. In World J Biol Chem, 2014
So far, FoxO1, FoxO3a, FoxO4 and FoxO6 proteins have been identified in humans.
FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis.
Bernardi et al., In Cell Mol Life Sci, 2014
The four FoxO members in humans, FoxO1, FoxO3, FoxO4, and FoxO6, are all expressed in skeletal muscle, but the first three members are the most studied in muscle.
PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor.
Khosravi-Far et al., Boston, United States. In Discoveries (craiova), 2014
UNASSIGNED: FOXO family members (FOXOs: FOXO1, FOXO3, FOXO4 and FOXO6) are important transcription factors and tumor suppressors controlling cell homeostasis and cell fate.
FoxO6 integrates insulin signaling with MTP for regulating VLDL production in the liver.
Dong et al., Pittsburgh, United States. In Endocrinology, 2014
To understand the underlying mechanism, we studied hepatic regulation of VLDL-TG production by (forkhead box O6) FoxO6, a forkhead transcription factor that integrates insulin signaling to hepatic metabolism.
Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin αvβ3 receptor in undifferentiated and differentiated PC-12 cells.
Mikeladze et al., Tbilisi, Georgia. In Cell Biochem Funct, 2014
Differentiation was induced by treatment of PC-12 cells with fisetin and the levels of phosphorylated extracellular signal-regulated kinase (ERK) and Akt in cytoplasm, as well as the content of FoxO6 transcription factor in nuclei was analysed in undifferentiated and differentiated conditions.
The essential role of FoxO6 phosphorylation in aging and calorie restriction.
Chung et al., Pusan, South Korea. In Age (dordr), 2013
However, the precise role that FoxO6, a novel member of the FoxO class of transcription factors, plays in the aging kidney has not been determined.
FOXO3a involvement in the release of TNF-α stimulated by ATP in spinal cord astrocytes.
Zhu et al., Shenyang, China. In J Mol Neurosci, 2013
However, ATP had no effect on the expression of FOXO4 and FOXO6, and EGFR, Akt, and ERK1/2 all involve in the release of interleukin (IL)-6 and tumor necrosis factor-α (TNF-α) induced by ATP.
FoxO6 in glucose metabolism (FoxO6).
Dong et al., Pittsburgh, United States. In J Diabetes, 2013
The forkhead box O (FoxO) subfamily has four members, namely FoxO1, FoxO3, FoxO4, and FoxO6.
ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.
Takahashi et al., Kanazawa, Japan. In Mol Cell Biol, 2013
Here we report that the genetic interaction of Rb and ATM regulates DNMT1 protein stability and hence controls the DNA methylation status in the promoters of at least the Ink4a, Shc2, FoxO6, and Noggin genes.
Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging.
Schubert et al., Köln, Germany. In Exp Clin Endocrinol Diabetes, 2012
Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging.
Role of forkhead transcription factors in diabetes-induced oxidative stress.
Graves et al., Philadelphia, United States. In Exp Diabetes Res, 2011
The FOXO family of forkhead transcription factors including FOXO1, FOXO3, FOXO4, and FOXO6 play important roles in the regulation of many cellular and biological processes and are critical regulators of cellular oxidative stress response pathways.
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins.
Ramakrishnan et al., Jackson, United States. In Biochim Biophys Acta, 2011
Studies indictet that the mammalian FoxO family consists of FoxO1, 3, 4 and 6 and are regulated by by AKT and 14-3-3 proteins.
FoxO6 integrates insulin signaling with gluconeogenesis in the liver.
Dong et al., Pittsburgh, United States. In Diabetes, 2011
investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in hepatocytes orchestrates insulin regulation of gluconeogenesis.
Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.
Nebel et al., Kiel, Germany. In Aging Cell, 2011
gene study of FOXO6, reveals no association with human longevity in Germans
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
Schmitt et al., Marburg an der Lahn, Germany. In Genes Dev, 2007
FoxO factors mediate Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity.
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