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Forkhead box O4

This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: FOXO1, FOXO3a, Akt, CAN, Insulin
Papers on FOXO4
Overexpression of FOXO4 induces apoptosis of clear-cell renal carcinoma cells through downregulation of Bim.
Hu et al., Wuhan, China. In Mol Med Report, Feb 2016
UNASSIGNED: Forkhead box O4 (FOXO4) has been reported to be a novel tumor suppressor gene in gastrointestinal cancers; however, its role in clear‑cell renal carcinoma cells (ccRCC) has remained largely elusive.
Identification of miRNAs and differentially expressed genes in early phase non-small cell lung cancer.
Yuan et al., Cangzhou, China. In Oncol Rep, Feb 2016
Genes S100P, ALOX15B, CCL11, NLRP2, SERPINA3, FoxO4 and hsa-miR-491 may play important roles in the development of early-stage NSCLC.
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.
Link et al., Faro, Portugal. In Aging Cell, Jan 2016
Invertebrate genomes have one FOXO gene, while mammals have four FOXO genes: FOXO1, FOXO3, FOXO4, and FOXO6.
Atypical Fibroxanthoma: A case series and review of literature.
Stewart et al., Epsom, United Kingdom. In Auris Nasus Larynx, Dec 2015
INTRO/OBJECTIVE: Atypical Fibroxanthoma (AFX) is a rare cutaneous neoplasm arising from myofibroblast or fibroblast-like cells that predominantly affects the head and neck region.
Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.
Verstuyf et al., Leuven, Belgium. In J Steroid Biochem Mol Biol, Aug 2015
By crossing Collagen2-Cre mice with FoxO1(lox/lox);FoxO3a(lox/lox);FoxO4(lox/lox) mice, we generated mice in which the three main FoxO isoforms were deleted in growth plate chondrocytes (chondrocyte triple knock-out; CTKO).
SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch.
Jiang et al., In Cell Physiol Biochem, 2014
The expression of SIRT1 and FOXO3a was increased by the stretch, but the expression of FOXO4 was decreased.
Screening feature genes of lung carcinoma with DNA microarray analysis.
Yuan et al., Wuhan, China. In Int J Clin Exp Med, 2014
The transcription biding site analysis showed that these genes were regulated by LHX3, HNF3B, CDP, HFH1, FOXO4, STAT, SOX5, MEF2, FOXO3 and SRY.
High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review.
Kraut et al., Southfield, United States. In Am J Case Rep, 2014
BACKGROUND: A subset of undifferentiated small round cell sarcomas (USRCSs) is currently being recognized as emerging entities with unique gene fusions: CIC-DUX4 (the area of focus in this article), BCOR-CCNB3, or CIC-FOXO4 gene fusions.
microRNA-150 promotes cervical cancer cell growth and survival by targeting FOXO4.
Liu et al., Chongqing, China. In Bmc Mol Biol, 2014
Moreover, miR-150 directly reduced the expression of FOXO4, which regulates the expression of CyclinD1, p27, BIM, and FASL, by targeting its 3' UTR.
FoxO3a and disease progression.
Hergert et al., Minneapolis, United States. In World J Biol Chem, 2014
So far, FoxO1, FoxO3a, FoxO4 and FoxO6 proteins have been identified in humans.
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.
Dillin et al., Los Angeles, United States. In Nature, 2012
FOXO4, an insulin/insulin-like growth factor-I (IGF-I) responsive transcription factor associated with long lifespan in invertebrates, regulates proteasome activity by modulating the expression of PSMD11 in hESCs.
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
Coffer et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
To identify transcriptional targets of this network, we performed global transcriptional analyses after conditional activation of the key components PI(3)K, PKB/Akt, FOXO3 and FOXO4.
Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA.
You et al., Xiamen, China. In Proc Natl Acad Sci U S A, 2012
Inhibition of endogenous FOXO proteins attenuated tetradecanoylphorbol Acetate/PDGF-BB mediated differentiation of neuroblastoma cells.
Human labour is associated with decreased cytoplasmic FoxO4.
Lappas et al., Melbourne, Australia. In Placenta, 2012
Data suggest that expression of cytoplasmic FoxO4 in placenta, fetal membranes, and decidua is altered by parturition/labor, preterm chorioamnionitis, and pro-inflammatory stimuli; silencing of FoxO4 gene initiates apoptosis in placental cell lines.
FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells.
Liu et al., Dallas, United States. In Atherosclerosis, 2011
FoxO4 inhibits atherosclerosis through bone marrow derived cells, possibly by inhibition of reactive oxygen species and inflammatory cytokines that promote monocyte recruitment and/or retention.
Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor.
Tsuda et al., Ōbu, Japan. In Aging (albany Ny), 2011
In NIH3T3 cells, tetrahydrocurcumin induced nuclear accumulation of FOXO4
[Expression and clinical significance of FOX04 in colorectal cancer].
Hai-feng et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
FOXO4 may function as a tumor suppressor in the development and progression of colorectal cancer.
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Manolagas et al., Little Rock, United States. In Cell Metab, 2010
Conditional deletion of FoxO1, FoxO3, and FoxO4 in 3-month-old mice resulted in an increase in oxidative stress in bone and osteoblast apoptosis and a decrease in the number of osteoblasts, the rate of bone formation, and bone mass at cancellous and cortical sites.
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
DePinho et al., Boston, United States. In Cell, 2007
The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting genetic analysis of the role of FoxOs in the neoplastic phenotypes linked to PI3K-AKT activation.
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Gilliland et al., Boston, United States. In Cell, 2007
To understand the role of FoxO family members in hematopoiesis, we conditionally deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system.
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