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Forkhead box I1

Foxi1, HFH-3
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PGD2, Kir4.1, CAN, int-2, FATE
Papers using Foxi1 antibodies
Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS).
Callaerts Patrick, In PLoS ONE, 1995
... Antibodies were diluted as follows: goat anti-Foxi1 1∶500 (AbCam); rabbit anti-B1 subunit of ...
Papers on Foxi1
Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw.
Yan et al., Shanghai, China. In Stem Cells, Mar 2015
By combining the hierarchical gene ontology term network, the DAVID annotation system, and Euclidean distance clustering, we identified four signaling pathways: foxi1-foxo1b-pou3f1, pax3a-mant3a-col11/col2, pou5f1-cdx4-kdrl, and isl1-wnt11 PCP-sox9a.
Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist.
Ozinsky et al., Seattle, United States. In Bmc Genomics, 2014
Analysis of the promotors of LPS-responsive genes that were perturbed by Type A Francisella infection identified candidate transcription factors that were potentially modulated by the bacteria, including multiple members of the forkhead transcription factor family (FoxA1, Foxa2, FoxD1, Foxd3, Foxf2, FoxI1, Fox03, Foxq1), IRF1, CEBPA, and Mef2.
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish.
Liu et al., Beijing, China. In Dev Dyn, 2014
The caudal PPR fate dominates when foxi1 expression is enhanced at the late gastrula stage, and depleting Foxi1 after 6 hours postfertilization (hpf) reduces the otic-epibranchial placodal domain.
Early embryonic specification of vertebrate cranial placodes.
Schlosser, Galway, Ireland. In Wiley Interdiscip Rev Dev Biol, 2014
During gastrulation, domains of ventrally (e.g., Dlx3/Dlx5, GATA2/GATA3, AP2, Msx1, FoxI1, and Vent1/Vent2) and dorsally (e.g., Zic1, Sox3, and Geminin) restricted transcription factors are established in response to a gradient of BMP and help to define non-neural and neural competence territories, respectively.
Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
Groves et al., Houston, United States. In Dev Biol, 2014
Zebrafish foxi1 is also expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 also causes apoptosis of neural crest in the branchial arches.
Intrafamilial phenotypic variability in families with biallelic SLC26A4 mutations.
Choi et al., South Korea. In Laryngoscope, 2014
Genetic analysis for SLC26A4 and other genes including FOXI1, FOXI1-DBD, and KCNJ10 was performed.
A screen of zebrafish mutants identifies ethanol-sensitive genetic loci.
Eberhart et al., Austin, United States. In Alcohol Clin Exp Res, 2014
Phenotypes of hinfp, mars, and foxi1 mutants were also exacerbated by EtOH.
[Current status and perspectives of the research in Pendred syndrome].
Hosoya et al., Tokyo, Japan. In Nihon Rinsho, 2013
Recently, mutations in FOXI1 and KCNJ10 have also been identified in DFNB4.
Mutation analysis of the SLC26A4, FOXI1 and KCNJ10 genes in individuals with congenital hearing loss.
Schrijver et al., Stanford, United States. In Peerj, 2013
We also examined the potential involvement of digenic inheritance in PDS/DFNB4 by sequencing the coding regions of FOXI1 and KCNJ10.
Molecular etiology of hearing impairment associated with nonsyndromic enlarged vestibular aqueduct in East China.
Yang et al., Shanghai, China. In Am J Med Genet A, 2013
Recessive mutations in SLC26A4 and in rarer cases double heterozygous mutations of FOXI1/SLC26A4 and KCNJ10/SLC26A4 lead to hearing impairment associated with enlarged vestibular aqueduct (EVA), the most common inner ear malformation.
Lack of significant association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations in Pendred syndrome/enlarged vestibular aqueducts.
Bitner-Glindzicz et al., London, United Kingdom. In Bmc Med Genet, 2012
Two genes, KCNJ10, encoding an inwardly rectifying potassium channel and FOXI1, a transcriptional factor gene, are thought to play a role in the disease phenotypes.
Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish.
Zhang et al., Beijing, China. In Cell Death Dis, 2012
Miles-apart (Mil) dysregulation also caused abnormal expression of hearing-associated genes, including hmx2, fgf3, fgf8a, foxi1, otop1, pax2.1 and tmieb during zebrafish organogenesis.
Screening of SLC26A4, FOXI1, KCNJ10, and GJB2 in bilateral deafness patients with inner ear malformation.
Jiang et al., Guangzhou, China. In Otolaryngol Head Neck Surg, 2012
No FOXI1 mutations were present in bilateral deafness patients with inner ear malformation.
Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24.
Riley et al., College Station, United States. In Dev Biol, 2011
pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development
Molecular and functional characterization of human pendrin and its allelic variants.
Paulmichl et al., Salzburg, Austria. In Cell Physiol Biochem, 2010
In performing genetic studies, the possibility that the mutation could affect regions other than the pendrin coding region, such as its promoter region and/or the coding regions of functionally related genes (FOXI1, KCNJ10), should be taken into account.
Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct.
Marlin et al., Paris, France. In Int J Pediatr Otorhinolaryngol, 2010
SLC26A4, FOXI1 and KCNJ10 are not major determinants in unilateral deafness and enlarged vestibular aqueduct
Requirement for Shh and Fox family genes at different stages in sweat gland development.
Schlessinger et al., Baltimore, United States. In Hum Mol Genet, 2009
Foxa1 and Foxi1 are required for later stage sweat gland development.
The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis.
Enerbäck et al., Göteborg, Sweden. In Plos One, 2008
Data suggestthat Foxi1 is necessary for expression of at least four subunits in three different epithelia and most likely is a major determinant for proper assembly of a functional vacuolar H(+)-ATPase complex at these locations.
Human FOX gene family (Review).
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
Pendred Syndrome/DFNB4
Smith et al., Seattle, United States. In Unknown Journal, 1998
Pathogenic variants in three known genes account for approximately half of PDS/DFNB4 cases: SLC26A4 (~50% of affected individuals), FOXI1 (<1%), and KCNJ10 (<1%), suggesting further genetic heterogeneity.
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