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Forkhead box F1a

Foxf1, FREAC-1, HFH-8
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HNF-3, FOXC2, Gli, FOXL1
Papers on Foxf1
Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?
Le Maitre et al., Utrecht, Netherlands. In Oncotarget, Jan 2016
qRT-PCR results were used to select NP marker candidates for protein expression analysis.Differential expression at mRNA between AC and non-degenerate NP cells was only observed for Paired Box Protein 1 (PAX1) and Forkhead box F1 (FOXF1).
Prenatal Diagnosis of Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins.
Killen et al., Nashville, United States. In J Pediatr, Jan 2016
We present a presumptive prenatal diagnosis of ACDMPV based on chorionic villus sampling of a FOXF1 mutation in a fetus with extra-pulmonary anomalies often associated with ACDMPV.
Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association.
Hildebrandt et al., Bonn, Germany. In Hum Mutat, Dec 2015
As mutations in ciliary genes were observed in diseases related to VATER/VACTERL, we performed targeted resequencing of 25 ciliary candidate genes as well as disease-associated genes (FOXF1, HOXD13, PTEN, ZIC3) in 123 patients with VATER/VACTERL or VATER/VACTERL-like phenotype.
Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response.
Kalinichenko et al., Cincinnati, United States. In Oncotarget, Dec 2015
UNASSIGNED: Forkhead box F1 (Foxf1) transcription factor is an important regulator of embryonic development but its role in tumor cells remains incompletely understood.
Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma.
Schumacher et al., Bonn, Germany. In Cancer Med, Nov 2015
Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's esophagus.
FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.
Kouskoff et al., Göteborg, Sweden. In Development, Nov 2015
In the present study, we investigated both in vitro in differentiating embryonic stem cells, and in vivo in gastrulating embryos, the lineage specification of early mesodermal precursors expressing or not the Forkhead transcription factor FOXF1.
A 16q deletion involving FOXF1 enhancer is associated to pulmonary capillary hemangiomatosis.
Damante et al., Udine, Italy. In Bmc Med Genet, 2014
CGHa revealed a heterozygous chromosome 16q23.3q24.1 interstitial deletion, spanning about 2.6 Mb and involving a FOXF1 gene enhancer.
Prognostic relevance of cancer-associated fibroblasts in human cancer.
Micke et al., Stockholm, Sweden. In Semin Cancer Biol, 2014
This includes members of the platelet derived growth factor receptor (PDGFR) family, CAF-markers like podoplanin and fibroblast activation protein (FAP) as well as transcription factors (FoxF1) and secreted factors (matrix metalloproteinases (MMPs), SPARC).
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
Vaughan et al., Seattle, United States. In Nat Genet, 2013
We also refine a previously reported association with Barrett's esophagus near the putative tumor suppressor gene FOXF1 at 16q24 and extend our findings to now include esophageal adenocarcinoma.
Cancer genetics and genomics of human FOX family genes.
Katoh et al., Tokyo, Japan. In Cancer Lett, 2013
FOXF1 overexpression in breast cancer is associated with epithelial-to-mesenchymal transition (EMT).
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.
Wellcome Trust Case Control Consortium 2 et al., Oxford, United Kingdom. In Nat Genet, 2012
for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure.
The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.
Sukumar et al., Columbia, United States. In Cell Signal, 2012
FOXF1 expression is predominantly silenced in breast and colorectal cancer cell lines with inactive p53
Analysis of FOXF1 and the FOX gene cluster in patients with VACTERL association.
Solomon et al., Bethesda, United States. In Eur J Med Genet, 2011
Results from mutational analysis of FOXF1 showed normal sequences and no genomic imbalances affecting the FOX gene cluster on chromosome 16q24 in the studied patients.
Differential expression of invasion promoting genes in childhood rhabdomyosarcoma.
Seitz et al., Tübingen, Germany. In Int J Oncol, 2011
FOFOXF1 was highly expressed in metastatic rhabdomyosarcoma, alveolar tumor samples and with a significant lower expression in non-metastatic samples
Review of genetic factors in intestinal malrotation.
Shaw-Smith et al., Cambridge, United Kingdom. In Pediatr Surg Int, 2010
Recognition of a specific syndrome is possible, one of several examples discussed being the recently described association of intestinal malrotation with alveolar capillary dysplasia, due to mutations in the forkhead box transcription factor FOXF1.
Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.
Ostman et al., Stockholm, Sweden. In Cancer Res, 2010
Observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors.
Genetic factors in esophageal atresia, tracheo-esophageal fistula and the VACTERL association: roles for FOXF1 and the 16q24.1 FOX transcription factor gene cluster, and review of the literature.
Shaw-Smith, Cambridge, United Kingdom. In Eur J Med Genet, 2010
A role for FOXF1 in esophageal atresia, tracheoesophageal fistula and the VACTERL association is presented.
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Katoh et al., Japan. In Curr Mol Med, 2009
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin.
Transcriptional control of lung morphogenesis.
Whitsett et al., Cincinnati, United States. In Physiol Rev, 2007
In contrast, a group of distinct proteins, including FOXF1, POD1, GLI, and HOX family members, play important roles in the developing lung mesenchyme, from which pulmonary vessels and bronchial smooth muscle develop.
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