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Forkhead box D2

FOXD2, freac-9, FKHL17
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, satin, Lun, Foxe3, Foxf1
Papers on FOXD2
Prenatal mercury concentration is associated with changes in DNA methylation at TCEANC2 in newborns.
Fallin et al., Baltimore, United States. In Int J Epidemiol, Aug 2015
RESULTS: Total mercury concentration was associated with methylation at DMRs inside ANGPT2 and near PRPF18 genes [false discovery rate (FDR) < 0.05], as well as DMRs near FOXD2 and within TCEANC2 (FDR< 0.1) genes.
Methylome profiling reveals functions and genes which are differentially methylated in serrated compared to conventional colorectal carcinoma.
Conesa et al., Santa Lucía, Spain. In Clin Epigenetics, 2014
Microarray data showed a higher representation of morphogenesis-, neurogenesis-, cytoskeleton- and vesicle transport-related functions and also significant differential methylation of 15 genes, including the iodothyronine deiodinase DIO3 and the forkhead family transcription factor FOXD2 genes which were validated at the CpG, mRNA and protein level using pyrosequencing, methylation-specific PCR, quantitative polymerase chain reaction (qPCR) and immunohistochemistry.
Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP.
Yasuda et al., Fukui, Japan. In Free Radic Biol Med, 2012
identified transcription factors FOXD2 and GABP that bind to specific elements in the promoter of the RhitH gene
Gene expression of forkhead transcription factors in the normal and diseased human prostate.
Jenster et al., Rotterdam, Netherlands. In Bju Int, 2009
FOXD1 and FOXD2 were more highly expressed in prostate cancer and lymph node metastases.
Forkhead transcription factors in immunology.
Peng et al., Saint Louis, United States. In Cell Mol Life Sci, 2005
Roles for other forkhead genes have also been proposed, including Foxp1 in macrophage differentiation, Foxq1 in natural killer cell effector function and Foxd2 in T cell activation.
Human FOX gene family (Review).
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34.
Brodeur et al., Philadelphia, United States. In Oncogene, 2004
In all, 17 of these were selected as likely candidates based on annotation using Gene Ontology Consortium terms, including the MUTYH, PRDX1, FOXD2, FOXE3, PTCH2, and RAD54L genes.
A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha.
Taskén et al., Oslo, Norway. In J Biol Chem, 2003
FOXD2 is a physiological regulator which increases cAMP sensitivity and sets the threshold for cAMP-mediated negative modulation of T cell activation
An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.
Holland et al., San Diego, United States. In Dev Dyn, 2002
Phylogenetic analysis indicates that the AmphiFoxD is basal to vertebrate FoxD1, FoxD2, FoxD3, FoxD4, and FoxD5.
Temporal and spatial expression patterns of FoxD2 during the early development of Xenopus laevis.
Knöchel et al., Ulm, Germany. In Mech Dev, 2002
We have investigated the sequence and expression pattern of the Xenopus laevis FoxD2 gene, a member of the fork head/winged helix multigene family.
Cloning and characterization of freac-9 (FKHL17), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34.
Enerbäck et al., Stockholm, Sweden. In Genomics, 1997
We describe the cloning of a near full-length cDNA of 4258 nucleotides encoding freac-9 (HGMW-approved symbol FKHL17), a novel human forkhead gene.
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