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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


follistatin, FST
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, SFRP1, V1a, Brain-derived neurotrophic factor
Papers using follistatin antibodies
Structural basis for the inhibition of activin signaling by follistatin
Hogan Brigid L. M, In PLoS Biology, 2005
... K14-Follistatin transgenic mice in a B6D2F1 × ...
Papers on follistatin
Antidepressant Effect of Cnestis ferruginea Vahl ex DC (Connaraceae): Involvement of Cholinergic, Monoaminergic and L-arginine-nitric Oxide Pathways.
Adeyemi et al., Lagos, Nigeria. In Drug Res (stuttg), Feb 2016
Methods: Male albino mice were pretreated with monoaminergic or cholinergic receptor antagonists, L-arginine or N(G)-nitro-L-arginine (nitric oxide synthase inhibitor) (at doses reported to block the in vivo effect of the agonists), 15 min before oral administration of CF (100 mg/kg), 1 h later, the forced swim test (FST) in mice was carried out.
Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress.
Galea et al., Colombia. In Horm Behav, Feb 2016
Testosterone also facilitated the effects of imipramine by reducing the latency to immobility in the FST and increasing sucrose preference.
Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.
Shoenfeld et al., Ramat Gan, Israel. In Vaccine, Feb 2016
At six months of age, Gardasil and Al-injected mice spent significantly more time floating in the forced swimming test (FST) in comparison to vehicle-injected mice (Al p=0.009;
Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice.
Li et al., Zhengzhou, China. In Neurosci Lett, Feb 2016
The present results showed that exogenous corticosterone injection caused depressive-like behaviors in mice, such as decreased sucrose intake in sucrose preference test (SPT) and increased immobility time in forced swimming test (FST).
The Sertoli cell as the orchestra conductor of spermatogenesis: spermatogenic cells dance to the tune of testosterone.
Sofikitis et al., In Hormones (athens), Feb 2016
Activin A, follistatin and FSH control germ cell development.
Angiogenic factors and inflammation in steroid-refractory acute graft-vs-host disease.
Arora et al., Minneapolis, United States. In Transl Res, Jan 2016
In this review, we summarize the data relevant to angiogenic factors that may contribute to healing after aGVHD (epidermal growth factor and vascular endothelial growth factor A) and angiogenic factors that may promote inflammation after aGVHD (placental growth factor and follistatin).
The potential role of activin and follistatin in lung transplant dysfunction.
Snell et al., Melbourne, Australia. In Expert Rev Respir Med, Dec 2015
Dysregulation of activin A and its naturally occurring antagonist follistatin, contribute to the development of disease in multiple organ systems.
Recent research advances in eosinophilic esophagitis.
Oyoshi, Boston, United States. In Curr Opin Pediatr, Dec 2015
Epithelial barrier protein desmoglein 1, bone morphogenetic protein antagonist follistatin, neurotrophic tyrosine kinase receptor type 1, and CAPN14 have been defined as new potential therapeutic targets in EoE as regulators of the inflammatory interleukin-13-axis.
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart.
Ruiz-Lozano et al., San Diego, United States. In Nature, Oct 2015
Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1).
The Involvement of GABAB signaling in the Antipsychotic-like Action of the Novel Orthosteric Agonist of mGlu4 Receptor, LSP4-2022.
Wieronska et al., Kraków, Poland. In Curr Neuropharmacol, Jun 2015
Social interaction,modified forced swim test (FST)and novel object recognition (NOR) test were used as the models for negative and cognitive symptoms of schizophrenia.LSP4-2022 dose-dependently (0.5-2 mg/kg) inhibited hyperactivity induced by MK-801 or amphetamine, and DOI-induced head twitches.
Association of follistatin-like 3 concentrations in serum and synovial fluid with the radiographic severity of knee osteoarthritis.
Bu et al., Tianjin, China. In Int J Clin Exp Med, 2014
OBJECTIVE: Follistatin-like 3 (FSTL3), a circulating glycoprotein, is correlated with obesity and inflammation, which are potential mechanisms of osteoarthritis (OA).
'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing.
Sampath et al., Singapore, Singapore. In Nature, 2013
Expression of primate-specific exonic microRNA-198 (miR-198), located in the 3'-untranslated region of follistatin-like 1 (FSTL1) messenger RNA, switches to expression of the linked open reading frame of FSTL1 upon wounding in a human ex vivo organ culture system.
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
Gregorevic et al., Australia. In J Cell Biol, 2012
regulation of Smad3- and mTOR-dependent events by follistatin occurred independently of overexpression or knockout of myostatin, a key repressor of muscle development that can regulate Smad3 and mTOR signaling and that is itself inhibited by follistatin
Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women.
Schroeder et al., Los Angeles, United States. In J Strength Cond Res, 2012
After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed higher levels of follistatin while postmenopausal women using HT showed a significant increased expression over controls.
Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action.
Singh et al., Los Angeles, United States. In Mol Cell Endocrinol, 2012
We conclude that testosterone stimulation of satellite cell proliferation and myogenic differentiation are associated with up regulation of Fst and inhibition of TGF-beta-signaling.
Strength training with blood flow restriction diminishes myostatin gene expression.
Tricoli et al., São Paulo, Brazil. In Med Sci Sports Exerc, 2012
LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression.
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma.
Pfister et al., Heidelberg, Germany. In J Clin Oncol, 2011
The prognostic power of follistatin-like 5 (FSTL5) immunopositivity was tested for 235 nonoverlapping medulloblastoma samples on two independent tissue microarrays.
A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood.
Liu et al., Nantong, China. In Genet Mol Res, 2010
The ratio of follistatin/myostatin could be used to monitor the progress of target muscle atrophy and recovery.
Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects.
Liu et al., Toronto, Canada. In Nat Med, 2010
Administration of an interfering peptide that disrupts the D1-D2 receptor complex substantially reduced immobility in the forced swim test (FST) without affecting locomotor activity, and decreased escape failures in learned helplessness tests in rats.
The extraction of 3D shape in the visual system of human and nonhuman primates.
Orban, Leuven, Belgium. In Annu Rev Neurosci, 2010
Such neurons occur in CIP, AIP, TEs, and F5 (for first- or second-order disparity gradients), in MT/V5, in FST (for speed gradients), and in CIP and TEs (for texture gradients).
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