GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Colony stimulating factor 1 receptor
FMS, CSF-1R
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008] (from
NCBI)
Top mentioned proteins:
FLT3, CsF, CAN, M-CSF, HAD
Papers using
FMS
antibodies
Platelet-derived growth factor-AA increases IL-1beta and IL-8 expression and activates NF-kappaB in rheumatoid fibroblast-like synoviocytes
Supplier
In Arthritis Research & Therapy, 2003
... Anti-c-Fms, anti-phospho-c-Fms, and isotype control antibodies were from Santa Cruz Biotechnology, Inc ...
Papers on
FMS
Induced Apoptosis Investigation in Wild-Type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single Cell qRT-PCR.
New
Columbus, United States. In Mol Ther, Feb 2016
UNASSIGNED: Nanochannel electroporation (NEP) was applied to deliver precise dosages of myeloid cell leukemia-1 (Mcl-1) specific siRNA and molecular beacons to two types of acute myeloid leukemia (AML) cells, FMS-like tyrosine kinase-3 wild type (WT) and internal tandem duplications (ITD) type at the single cell level.
Exploring new biomarkers in the tumour microenvironment of canine inflammatory mammary tumours.
New
Vila Real, Portugal. In Vet Comp Oncol, Feb 2016
Gene expression differences between CIMC and non-CIMC types were obtained for cyclooxygenase 2 (COX-2) (P = 0.004), synuclein gamma (SNCG) (P = 0.006), tribbles 1 (P = 0.025), vascular endothelial growth factor (VEGF) (P = 0.017) and CSF1R (P = 0.045).
Hereditary diffuse leukoencephalopathy with spheroids - a volumetric and radiological comparison with multiple sclerosis patients and healthy controls.
New
Stockholm, Sweden. In Eur J Neurol, Feb 2016
BACKGROUND AND PURPOSE: Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominant disorder caused by colony-stimulating factor 1 receptor (CSF1R) gene mutations, resulting in demyelination and axonal degeneration with spheroids.
The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia.
Review
New
Rotterdam, Netherlands. In Ther Adv Cardiovasc Dis, Feb 2016
Eventually, this results in the release of anti-angiogenic factors [in particular, soluble Fms-like tyrosine kinase-1 (sFlt-1)] and cytokines, leading to generalized vascular dysfunction.
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.
New
Southampton, United Kingdom. In Brain, Feb 2016
This mechanism is regulated by the activation of the colony-stimulating factor 1 receptor (CSF1R), thus providing a target that may prevent the progression of conditions such as Alzheimer's disease.
Avian dendritic cells: phenotype and ontogeny in lymphoid organs.
Review
New
Budapest, Hungary. In Dev Comp Immunol, Feb 2016
Bursal secretory dendritic cells (BSDC) are elongated cells which express vimentin intermediate filaments, MHC II molecules, macrophage colony-stimulating factor 1 receptor (CSF1R), and produce 74.3+ secretory granules.
Role of endothelin in preeclampsia and hypertension following antiangiogenesis treatment.
Review
New
Rotterdam, Netherlands. In Curr Opin Nephrol Hypertens, Jan 2016
PURPOSE OF REVIEW: Preeclampsia is a systemic, pregnancy-related disorder featuring hypertension and proteinuria arising from placental overproduction of soluble FMS-like tyrosine kinase-1, resulting in an antiangiogenic state because of the inhibition of the vascular endothelial growth factor (VEGF) family.
CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study.
New
Impact
Lyon, France. In Lancet Oncol, Aug 2015
CSF1 receptor (CSF1R) activation leads to the recruitment of CSF1R-expressing cells of the mononuclear phagocyte lineage that constitute the tumor mass in dt-GCT.
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.
New
Impact
Boca Raton, United States. In N Engl J Med, Aug 2015
This observation has led to the discovery and clinical development of therapy targeting the CSF1 receptor (CSF1R).
Therapeutic targeting of macrophages in lupus nephritis.
Review
New
United States. In Discov Med, Jul 2015
The current literature explores targeting macrophages by several different means, including the CSF-1/CSF-1R signaling axis, the CX3CL1/CX3CR1 signaling axis, the CCL2/CCR2 signaling axis, and Bruton's Tyrosine Kinase (BTK), all of which hold promise as targets for future LN treatments.
Overexpression of CSF-1R in nasopharyngeal carcinoma.
China. In Rom J Morphol Embryol, 2014
OBJECTIVES: The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis for assessing the role CSF-1÷CSF-1R in nasopharyngeal carcinoma.
Coexistent t(8;21)(q22;q22) Translocation and 5q Deletion in Acute Myeloid Leukemia.
Review
In J Clin Exp Hematop, 2014
Fluorescence in situ hybridization (FISH) on metaphase spreads detected a RUNX1/RUNX1T1 fusion signal on the der(8)t(8;21)(q22;q22), and confirmed deletion of CSF1R signaling at 5q33-q34 on the del(5)(q?).
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Impact
Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
Impact
Penzberg, Germany. In Cancer Cell, 2014
We generated a monoclonal antibody (RG7155) that inhibits CSF-1 receptor (CSF-1R) activation.
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.
Impact
New York City, United States. In Cancer Cell, 2014
This crosstalk enforces aggressive CD44(+)IGF1R(+)CSF1R(+) LC phenotypes, including extranodal invasion and chemoresistance.
The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation.
GeneRIF
New York City, United States. In Dev Biol, 2012
ablation of the Csf1r gene in Nestin-positive neural progenitors led to a smaller brain size, an expanded neural progenitor pool and elevated cellular apoptosis in cortical forebrain
Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis.
GeneRIF
San Antonio, United States. In Fertil Steril, 2012
Suggest that CSF-1 and its receptor, C-FMS, are involved in the genesis of early endometriotic lesions and that endometriotic lesions contribute to elevated CSF-1 levels in the peritoneal fluid of women with endometriosis.
Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807.
GeneRIF
New York City, United States. In J Biol Chem, 2012
Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.
Impact
GeneRIF
Jacksonville, United States. In Nat Genet, 2012
Genome-wide linkage analysis plus exome sequencing identified 14 different mutations affecting the tyrosine kinase domain of the colony stimulating factor 1 receptor in 14 families with hereditary diffuse leukoencephalopathy with spheroids.
Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.
GeneRIF
New York City, United States. In Mol Med, 2011
Study results provide a mechanistic explanation for the involvement of CSF-1 in glioblastoma progression and indicate that inhibition of CSF-1R signaling could provide a novel approach to limiting glioblastoma invasion
