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Flavin containing monooxygenase 5

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: FMO3, FMO2, ACID, CAN, CYP3A4
Papers on FMO5
Mattevi et al., In Acs Chem Biol, Feb 2016
While human FMO isoforms are typically involved in oxidation of soft nucleophiles, the biocatalytic activity of human FMO5 (along its physiological role) has long remained unexplored.
Preliminary study of FMO1, FMO5, CYP21, ESR1, PLIN2 and SULT2A1 as candidate gene for compounds related to boar taint.
Uddin et al., Bonn, Germany. In Meat Sci, Oct 2015
Significant association (P<0.05) was detected for SNP of FMO5 (g.494A>G) with all boar taint compounds, SNP of CYP21 (g.3911T>C) with skatole and indole, and SNP of ESR1 (g.672C>T) with androstenone and indole.
The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.
Shephard et al., London, United Kingdom. In Biochem Pharmacol, Sep 2015
We report the production and metabolic phenotype of a mouse line in which the Fmo5 gene is disrupted.
Metabolism of MRX-I, a novel antibacterial oxazolidinone, in humans: the oxidative ring opening of 2,3-Dihydropyridin-4-one catalyzed by non-P450 enzymes.
Chen et al., Shanghai, China. In Drug Metab Dispos, May 2015
Based on these results, the mechanism proposed for the DHPO ring opening involves the metabolism of MRX-I via FMO5-mediated Baeyer-Villiger oxidation to an enol lactone, hydrolysis to an enol, and enol-aldehyde tautomerism to an aldehyde.
Leveraging an Electronic Health Record-Linked Biorepository to Generate a Metformin Pharmacogenomics Hypothesis.
Pathak et al., Rochester, United States. In Amia Summits Transl Sci Proc, 2014
Using a cohort of 258 T2DM patients who had new metformin exposure, existing genetic data, and longitudinal electronic health records, we compared genetic variation within FMO5 to change in glycemic response.
The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent.
Rigas et al., Stony Brook, United States. In Biochem Pharmacol, 2014
FMO1, FMO3 and FMO5 were all capable of catalyzing the sulfoxidation (but not hydroxylation) of PSA, with FMO1 being by far the most active isoform.
Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque.
Yamazaki et al., Kainan, Japan. In Biochem Pharmacol, 2013
Among the 10 tissue types analyzed, cynomolgus FMO1, FMO2, FMO4, and FMO6 were most abundantly expressed in kidney, while cynomolgus FMO3 and FMO5 were most abundantly expressed in liver.
Regulation of FMO and PON detoxication systems in ALS human tissues.
Cereda et al., Pavia, Italy. In Neurotox Res, 2013
In contrast to FMO5 expression, the PON2 gene was down-regulated in ALS patients compared to the controls.
RNA deep sequencing reveals novel candidate genes and polymorphisms in boar testis and liver tissues with divergent androstenone levels.
Cinar et al., Bonn, Germany. In Plos One, 2012
Moreover, polymorphism and association analysis revealed mutation in IRG6, MX1, IFIT2, CYP7A1, FMO5 and KRT18 genes could be potential candidate markers for androstenone levels in boars.
Human gene copy number spectra analysis in congenital heart malformations.
Mitchell et al., Milwaukee, United States. In Physiol Genomics, 2012
Furthermore, CNV gene frequency spectra were enriched (P ≤ 0.05) for losses at: FKBP6, ELN, GTF2IRD1, GATA4, CRKL, TBX1, ATRX, GPC3, BCOR, ZIC3, FLNA and MID1; and gains at: PRKAB2, FMO5, CHD1L, BCL9, ACP6, GJA5, HRAS, GATA6 and RUNX1.
pH dependence on functional activity of human and mouse flavin-containing monooxygenase 5.
Cashman et al., San Diego, United States. In Biochem Pharmacol, 2012
A comparison of FMOs showed that the pH-dependence profile for functional activity of FMO5 differed significantly from that of other FMO enzymes.
Identification of enzymes responsible for the N-oxidation of darexaban glucuronide, the pharmacologically active metabolite of darexaban, and the glucuronidation of darexaban N-oxides in human liver microsomes.
Usui et al., Ōsaka, Japan. In Biol Pharm Bull, 2011
Recombinant human FMO3 and FMO1 were capable of efficiently catalyzing YM-222714 N-oxidation, but not FMO5 or any recombinant human cytochrome P450 (CYP) isoforms.
The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
Mazerska et al., Gdańsk, Poland. In Drug Metab Dispos, 2011
In contrast, both compounds were good substrates for human recombinant FMO1 and FMO3 but not for FMO5.
A rapid and sensitive CE method with field-enhanced sample injection and in-capillary derivatization for selenomethionine metabolism catalyzed by flavin-containing monooxygenases.
Van Schepdael et al., Leuven, Belgium. In Electrophoresis, 2010
The results showed that both FMO1 and FMO3, but not FMO5 could catalyze the Se-oxygenation of SeMet.
Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5.
Cashman et al., San Diego, United States. In J Biochem Mol Toxicol, 2006
The functional activity of Fmo5 was determined.
Quantitative analysis of FMO gene mRNA levels in human tissues.
Cashman et al., San Diego, United States. In Drug Metab Dispos, 2006
fmo5 displayed a significant, dominant liver-specific mRNA profile.
Pesticide-metabolizing enzymes.
Levi et al., Raleigh, United States. In Toxicol Lett, 1995
In mouse liver, the level of FMO1 is gender dependent, FMO3 is gender specific, while FMO5 appears to be gender independent.
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