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Neuromedin U receptor 2

receptor for the Nmu neuropeptide involved in the central control of feeding [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Actin, V1a, CAN, ACID, HAD
Papers using FM4 antibodies
Isolation, expression analysis, and functional characterization of the first antidiuretic hormone receptor in insects.
Lee Leo T. O., In PLoS ONE, 2009
... The ORF of the human neuromedin U receptor 2 (also referred to as FM4) was amplified from full-length cDNA clone (MHS1010-98075312, Thermo scientific) using specific primers: ...
Papers on FM4
The AP-2 complex is required for proper temporal and spatial dynamics of endocytic patches in fission yeast.
Valdivieso et al., Salamanca, Spain. In Mol Microbiol, Feb 2016
Here we report co-immunoprecipitation between the fission yeast AP-2 component Apl3p and clathrin, as well as the genetic interactions between apl3Δ and clc1 and sla2Δ/end4Δ mutants.Furthermore, a double clc1 apl3Δ mutant was found to be defective in FM4-64 uptake.
An aquaporin PvTIP4;1 from Pteris vittata may mediate arsenite uptake.
Ma et al., Beijing, China. In New Phytol, Jan 2016
Images and FM4-64 staining suggest that PvTIP4;1 localizes to the plasma membrane in P. vittata cells.
Stable Pseudohyphal Growth in Budding Yeast Induced by Synergism between Septin Defects and Altered MAP-kinase Signaling.
Rose et al., Princeton, United States. In Plos Genet, Dec 2015
They contain septin structures distinct from classical pseudo-hyphae and FM4-64 labeling at actively growing tips similar to the Spitzenkörper observed in true hyphal growth.
Evaluation of lower facial heights as related to different anthropometric measurements in dentate and completely edentulous subjects.
Hassan et al., In Quintessence Int, Dec 2015
Base of chin-subnasale measurement (FM1), base of chin-tip of the nose measurement (FM2), Willis' measurement (FM3), glabella-subnasale measurement (FM4), length of the index finger measurement (AM1), and tip of thumb-tip of index finger measurement (AM2) of subjects of G1 and G2 were measured by using a modified caliper while the subjects in G1 closed in centric occlusion, and the subjects of G2 were asked to close the maxillary and mandibular complete dentures in centric relation.
Characterization of Cytokinetic Mutants Using Small Fluorescent Probes.
Bozhkov et al., Pullman, United States. In Methods Mol Biol, Dec 2015
This chapter describes techniques for staining DNA with the probes DAPI and SYTO82, for staining membranes with FM4-64, and for staining cell wall with propidium iodide.
Exocyst-Positive Organelles and Autophagosomes Are Distinct Organelles in Plants.
Jiang et al., Shanghai, China. In Plant Physiol, Nov 2015
Tonoplast staining with FM4-64/YFP-Rab7-like GTPase/YFP-vesicle-associated membrane protein711 confirmed the internalization of tonoplast membrane concomitant with the sequestration of EXPO and autophagosomes.
Modification of hippocampal excitability in brain slices pretreated with a low nanomolar concentration of Zn2+.
Tamano et al., Shizuoka, Japan. In J Neurosci Res, Nov 2015
When mossy fiber excitation was assessed in brain slices with FM4-64, an indicator of presynaptic activity, attenuation of FM 4-64 fluorescence based on presynaptic activity was suppressed in the stratum lucidum of brain slices pretreated with ACSF containing Zn2+.
Characterization of the cellular response triggered by gold nanoparticle-mediated laser manipulation.
Heinemann et al., Hannover, Germany. In J Biomed Opt, Nov 2015
Experiments based on the inflow of FM4-64 indicated that the membrane remains permeable for a few minutes for small molecules.
[Optimization of labeling and localizing bacterial membrane and nucleus with FM4-64 and Hoechst dyes].
Zhao et al., In Wei Sheng Wu Xue Bao, Sep 2015
METHODS: FM4-64 and Hoechst were dyed that can label cell membrane and nucleus, respectively.
Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast.
Li et al., Beijing, China. In Plos One, 2014
As a result, the vesicle trafficking was disturbed, as determined by FM4-64 labeling.
Neuromedin U(2) receptor signaling mediates alteration of sleep-wake architecture in rats.
Drinkenburg et al., Beerse, Belgium. In Neuropeptides, 2011
Results show that central-activation of neuromedin U2 receptor markedly reduced sleep duration and disrupted the mechanisms underlying NREM-REM sleep transitions.
Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.
Davenport et al., Cambridge, United Kingdom. In Br J Pharmacol, 2009
Neuromedin U (NMU) has been paired with the G-protein-coupled receptors (GPRs) NMU(1) (formerly designated as the orphan GPR66 or FM-3) and NMU(2) (FM-4 or hTGR-1).
Neuromedin U directly stimulates growth of cultured rat calvarial osteoblast-like cells acting via the NMU receptor 2 isoform.
Malendowicz et al., Poznań, Poland. In Int J Mol Med, 2008
cultured rat calvarial osteoblast-like cells are provided with NMUR2, the receptor isoform typical for the central nervous system
Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue.
Willars et al., Leicester, United Kingdom. In J Pharmacol Exp Ther, 2008
endogenous rat NmU receptors couple to both Galpha(q/11) and Galpha(i) G-proteins. Challenge of either circular or longitudinal rat isolated colonic smooth muscle. preparations with NmU resulted in robust contractions
Neuromedin S: discovery and functions.
Kangawa et al., Suita, Japan. In Results Probl Cell Differ, 2007
Neuromedin S, a novel neuropeptide of 36 amino acids, was isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, identified to date as type-1 and type-2 neuromedin U (NMU) receptors, respectively.
Neuromedin s as novel putative regulator of luteinizing hormone secretion.
Tena-Sempere et al., Córdoba, Spain. In Endocrinology, 2007
Expression of NMS and NMU2R genes was detected at the hypothalamus along postnatal development, with significant fluctuations of their relative levels (maximum at prepubertal stage and adulthood).
Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.
Hu et al., Shanghai, China. In Neurosci Lett, 2006
A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist.
Endocytotic cycling of PM proteins.
Peer et al., West Lafayette, United States. In Annu Rev Plant Biol, 2004
The use of the styryl dye FM4-64 to define the course of endocytotic uptake and the fungal toxin brefeldin A to dissect the internalization pathways are particularly emphasized.
FM-dyes as experimental probes for dissecting vesicle trafficking in living plant cells.
Satiat-Jeunemaitre et al., Gif-sur-Yvette, France. In J Microsc, 2004
In this way, staining of the Golgi with FM4-64 has been demonstrated for the first time.
Identification of receptors for neuromedin U and its role in feeding.
Liu et al., Rahway, United States. In Nature, 2000
FM-3, designated NMU1R, is abundantly expressed in peripheral tissues whereas FM-4, designated NMU2R, is expressed in specific regions of the brain.
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