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Filaggrin family member 2

flg-2, Ifapsoriasin, filaggrin-2
Top mentioned proteins: Filaggrin, S-100, PrP, ACID, caspase-14
Papers on flg-2
Skin-Derived C-Terminal Filaggrin-2 Fragments Are Pseudomonas aeruginosa-Directed Antimicrobials Targeting Bacterial Replication.
Gerstel et al., Kiel, Germany. In Plos Pathog, Sep 2015
Due to its high abundance in the upper epidermis and eccrine sweat glands, filaggrin-2 (FLG2), a water-insoluble 248 kDa S100 fused-type protein, might possess these innate effector functions.
In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification.
Simon et al., Toulouse, France. In Cell Death Dis, 2014
In the epidermis of European patients, the expression of filaggrin-2, the filaggrin-related protein encoded by FLG2, is decreased.
Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.
Shimizu et al., Toyama, Japan. In Biochem Biophys Res Commun, 2014
Filaggrin-2 is a member of the S100 fused-type protein family, and the structural features and expression of filaggrin-2 are similar to those of profilaggrin, a protein essential for keratinization.
Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects.
Mitra et al., Philadelphia, United States. In J Allergy Clin Immunol, 2014
OBJECTIVE: We sought to evaluate genetic variation of filaggrin-2 (FLG2) in African American subjects with AD.
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
Simon et al., Toulouse, France. In J Allergy Clin Immunol, 2013
OBJECTIVES: We sought to evaluate the respective role of FLG mutations and proinflammatory cytokines and to assess the expression of FLG, hornerin (HRNR), and FLG2, 2 FLG-like proteins, which are involved in epidermal barrier functions, in normal skin and both lesional and nonlesional skin of patients with AD.
Isolation of human epidermal layers by laser capture microdissection: application to the analysis of gene expression by quantitative real-time PCR.
Follet-Gueye et al., Mont-Saint-Aignan, France. In Exp Dermatol, 2012
Using integrin alpha-6/integrin beta-4 and corneodesmosin/filaggrin-2 sets as gene markers for the basal and granular layers, respectively, we showed that Toll-like receptor 2, RNase 7, human beta-defensin-2 and -3, psoriasin and nucleotide-binding oligomerization domain 1 are upregulated in the suprabasal layer of normal human epidermis.
Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair.
Zeeuwen et al., Nijmegen, Netherlands. In Br J Dermatol, 2012
RESULTS: Upon tape stripping, several structural molecules were significantly downregulated (at the mRNA level as well as the protein level), including LCE5A, LCE2B, FLG, FLG2 and LOR, whereas others were upregulated: IVL, SPRR1, SPRR2, HRNR and most notably LCE3A.
Murine filaggrin-2 is involved in epithelial barrier function and down-regulated in metabolically induced skin barrier dysfunction.
Schröder et al., Kiel, Germany. In Exp Dermatol, 2012
Recently, we identified human filaggrin-2 as a new member of the SFTP family.
Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema.
Lee et al., Berlin, Germany. In J Invest Dermatol, 2011
Of these, 4 were validated in 94 eczema patients: a nonsense mutation in FLG2 (rs12568784), a stop codon mutation in LCE1D (rs41268500), a 24-bp deletion in SPRR3 (rs28989168), and a frameshift mutation in S100A3 (rs11390146).
Deimination of human filaggrin-2 promotes its proteolysis by calpain 1.
Simon et al., Toulouse, France. In J Biol Chem, 2011
calpain 1 is essential for the proteolytic processing of FLG2 and that deimination accelerates this process.
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization.
Leung et al., Denver, United States. In J Allergy Clin Immunol, 2011
RESULTS: Proteins related to the skin barrier (filaggrin-2, corneodesmosin, desmoglein-1, desmocollin-1, and transglutaminase-3) and generation of natural moisturizing factor (arginase-1, caspase-14, and gamma-glutamyl cyclotransferase) were expressed at significantly lower levels in lesional versus nonlesional sites of patients with AD with and without history of eczema herpeticum; epidermal fatty acid-binding protein was expressed at significantly higher levels in patients with methicillin-resistant S. aureus.
Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family.
Schröder et al., Kiel, Germany. In Plos One, 2008
FLG2 and filaggrin may have overlapping and perhaps synergistic roles in the formation of the epidermal barrier, protecting the skin from environmental insults and the escape of moisture by offering precursors of natural moisturizing factors
Flg-2, a new member of the family of fibroblast growth factor receptors.
Givol et al., Israel. In Oncogene, 1991
Here we report the molecular cloning and sequence of a new member of the FGF receptor family, denoted flg-2, which was isolated from a human keratinocyte cDNA library.
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