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Arachidonate 5-lipoxygenase-activating protein

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: 5-lipoxygenase, ACID, HAD, CAN, cyclooxygenase
Papers using FLAP antibodies
Cysteinyl Leukotrienes and Uridine Diphosphate Induce Cytokine Generation by Human Mast Cells Through an Interleukin 4–regulated Pathway that Is Inhibited by Leukotriene Receptor Antagonists
Boyce Joshua A. et al., In The Journal of Experimental Medicine, 2000
... ); MK886 (1 μM), an inhibitor of FLAP (26) and LTC4S (27) (both from Cayman); the selective MEK inhibitor ...
Papers on FLAP
Genetics of ischemic stroke: An Indian scenario.
Prasad et al., New Delhi, India. In Neurol India, Jan 2016
Combined linkage/association studies have demonstrated that genes encoding phosphodiesterase 4D (PDE4D) and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) confer risk for stroke.
The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease.
Strosznajder et al., Warsaw, Poland. In Neurochem Res, Jan 2016
The protein/protein interaction also is involved in the mechanism of 5-LOX regulation through FLAP protein and coactosin-like protein.
Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients.
Irimia et al., Boston, United States. In Crit Care Med, Dec 2015
Individually, ALOX12, PTGS2, PTGES, PTGDS, ALOX5AP, LTA4H, FPR2, PTGER2, LTB4R, HPGD, PTGR1, and CYP4F3 were expressed differentially over 28 days posttrauma between patients with uncomplicated and complicated recoveries (p < 0.05).
Non-Zinc-Binding Inhibitors of MMP-13: GRID-Based Approaches to Rationalize the Binding Process.
Tortorella et al., Bari, Italy. In Curr Top Med Chem, Dec 2015
In particular, FLAP, a program based on GRID molecular interaction fields, was used to analyze the ligand-protein interactions: molecular shape and hydrogen bond acceptor groups strongly influence the binding according to the ligand-based modeling, while the aromatic interactions are better identified by the structure-based study.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Okuyama et al., Tokyo, Japan. In Redox Biol, Dec 2015
Importantly, 5-LOX activity is strictly regulated by 5-LOX activating protein (FLAP) though the distribution of 5-LOX in the nucleus.
The role of 12/15-lipoxygenase in production of selected eicosanoids in allergic airway inflammation.
Kowal et al., Białystok, Poland. In Adv Med Sci, Dec 2015
Whole lung samples were used for isolation of RNA and evaluation of selected genes involved in eicosanoid metabolism, including cyclooxygenase-2 (COX-2), 12/15-LOX, 5-LOX and 5-LOX activated protein (FLAP).
Recent advances for FLAP inhibitors.
Whatling et al., Mölndal, Sweden. In Bioorg Med Chem Lett, Aug 2015
A number of FLAP inhibitors have been progressed to clinical trials for respiratory and other inflammatory indications but so far no drug has reached the market.
The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis.
Kukla et al., Ostrava, Czech Republic. In Bmc Cardiovasc Disord, 2014
Using real time polymerase chain reaction and melting-curve analysis, we detected 13 single-nucleotide polymorphisms in 11 candidate genes - rs1803274 (BCHE gene), rs529038 (ROS1), rs1050450 (GPX1), rs1800849 (UCP3), rs17216473 (ALOX5AP), rs7412, rs429358 (ApoE), rs2228570 (VDR), rs7041, rs4588 (GC), rs1799986 (LRP1) and rs2228671 (LDLR).
Targeting 5-lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease.
Antoniu, Jászvásár, Romania. In Expert Opin Ther Targets, 2014
AREAS COVERED: The role of the 5-lipoxygenase-activating protein (FLAP) in generating proinflammatory molecules such as leukotrienes is discussed, highlighting, in particular, its potential as a therapeutic target in asthma and COPD.
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotype.
Praticò et al., Philadelphia, United States. In Front Cell Neurosci, 2013
Recent in vivo evidence using murine knock-out models has implicated the 5LO pathway, which also requires the 5LO activating protein (FLAP), in the molecular pathology of AD, including the metabolism of amyloid-β and tau.
Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population.
Kwack et al., South Korea. In Scand J Immunol, 2012
study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population
Association of ALOX5AP haplotypes with susceptibility to coronary artery disease in a Chinese Han population.
Han et al., Xi'an, China. In Eur J Intern Med, 2012
SNP haplotypes with susceptibility to coronary artery disease in a Chinese Han population
No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.
Mayeux et al., New York City, United States. In Neurobiol Aging, 2012
Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts.
The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms.
Norman et al., Amsterdam, Netherlands. In Atherosclerosis, 2012
ALOX5AP SNPs are unlikely to play a dominant role in the pathogenesis of abdominal aortic aneurysms.
The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.
Sayers et al., Nottingham, United Kingdom. In Bmc Med Genet, 2010
The polymorphisms spanning ALOX5AP is not major determinants of baseline lung function in smokers.
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Becker et al., Rahway, United States. In Science, 2007
x-ray crystal structures of FLAP in complex with two leukotriene biosynthesis inhibitors at 4.0 and 4.2 angstrom resolution, respectively; structures show that inhibitors bind in membrane-embedded pockets of FLAP
Genetics of ischaemic stroke.
Dichgans, München, Germany. In Lancet Neurol, 2007
Genome-wide linkage studies in extended pedigrees from Iceland led to the identification of PDE4D and ALOX5AP.
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2006
Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be associated with risk of myocardial infarction.
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial.
Stefansson et al., Reykjavík, Iceland. In Jama, 2005
Variants in the 5-lipoxygenase-activating protein (FLAP) gene are associated with risk of MI.
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2004
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
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