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Four jointed box 1

The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: HAD, TUBE, ACID, vasohibin-1, TIF
Papers on Fjx1
Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma.
Lim et al., Kuala Selangor, Malaysia. In Plos One, 2014
As our prior observations had found that four-jointed box 1 (FJX1), a tumor antigen, is overexpressed in NPCs, we investigated if short 9-20 amino acid sequence specific peptides matching to FJX1 requiring only intramuscular immunization to train host immune systems would be a better treatment option for this disease.
FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue.
Thorne et al., Newcastle, Australia. In Febs Lett, 2014
Given that many signalling functions are conserved between Drosophila and vertebrate Fat cadherins, we sought to determine whether ectodomain phosphorylation is conserved in FAT1 cadherin, and also whether FJX1, the vertebrate orthologue of four-jointed, was involved in such phosphorylation events.
Deficiency of the microRNA-31-microRNA-720 pathway in the plasma and endothelial progenitor cells from patients with coronary artery disease.
Cheng et al., Taipei, Taiwan. In Arterioscler Thromb Vasc Biol, 2014
FAT atypical cadherin 4 inhibited miR-720 expression via repression of the planar cell polarity signaling gene four-jointed box 1 (FJX1), which was required for miR-720 expression through a hypoxia-inducible factor 1, α subunit-dependent mechanism.
Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma.
Beauchamp et al., Nashville, United States. In Plos One, 2012
We identified four jointed box 1 (FJX1) as a candidate regulator of tumor angiogenesis in colorectal cancer.
Comparison of genomic signatures of non-small cell lung cancer recurrence between two microarray platforms.
Wang et al., Taiwan. In Anticancer Res, 2012
Using univariate analysis, four (lipocalin 2, LCN2; parathyroid hormone-like hormone, PTHLH; ras-related protein Rab-38, RAB38; and four jointed box 1, FJX1) of these six genes were associated with survival.
High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx.
Monni et al., Helsinki, Finland. In Genes Chromosomes Cancer, 2008
We identified a number of altered regions including nine high-level amplifications such as 6q12-q14 (CD109, MYO6), 9p24 (JAK2, CD274, SLC1A1, RLN1), 11p12-p13 (TRAF6, COMMD9, TRIM44, FJX1, CD44, PDHX, APIP), 11q13 (FADD, PPFIA1, CTTN), and 14q24 (ABCD4, HBLD1, LTBP2, ZNF410, COQ6, ACYP1, JDP2) where 9% to 64% of genes showed overexpression.
The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.
Püschel et al., Münster, Germany. In Dev Biol, 2008
These results identify Fjx1 as a new inhibitory factor that regulates dendrite extension.
Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.
Gessler et al., Würzburg, Germany. In Dev Dyn, 2005
data are compatible with conservation and sub-functionalization of dachsous 1, Fj, and Fat signaling in higher vertebrates
Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.
Gessler et al., Würzburg, Germany. In Dev Dyn, 2005
fjx1 is expressed in the peripheral nervous system, epithelial cells of multiple organs, and during limb development
Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma.
Albertson et al., San Francisco, United States. In Oncogene, 2005
We found genes involved in integrin signaling (TLN1), survival (YAP1, BIRC2), and adhesion and migration (TLN1, LAMA3, MMP7), as well as members of the hedgehog (GLI2) and notch (JAG1, RBPSUH, FJX1) pathways to be amplified and overexpressed.
Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain.
Gruss et al., Göttingen, Germany. In Mech Dev, 1999
Here we report the cloning of the mouse four-jointed gene (fjx1) and its pattern of expression in the brain during embryogenesis and in the adult.
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