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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Filamin, alpha

filamin A, dilp2, filamin, a
Top mentioned proteins: Actin, CAN, V1a, HAD, Insulin
Papers using filamin A antibodies
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
Kapus András et al., In The Journal of Cell Biology, 2003
... (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK (Invitrogen), E-cadherin and filamin A (clone 5/ABP280; BD), HA.11 (clone 16B12; Covance), and CapZ (AbD Serotec).
Kindlin-2 (Mig-2): a co-activator of β3 integrins
Plow Edward F. et al., In The Journal of Cell Biology, 2002
... -endonexin, and filamin A Ig-like domain 21 (2235–2330 amino acids) were cloned into pEGFP vectors (Clontech Laboratories, Inc.) ...
Papers on filamin A
Overexpression of filamin-A protein is associated with aggressive phenotype and poor survival outcomes in NSCLC patients treated with platinum-based combination chemotherapy.
Kolar et al., In Neoplasma, Feb 2016
UNASSIGNED: An actin-binding protein filamin A connects the actin filament network to cell membrane receptors, and acts as a scaffold for various signaling pathways related to cancer growth and progression.
Phosphatidylinositol 4-Phosphate 5-Kinase β Controls Recruitment of Lipid Rafts into the Immunological Synapse.
Viola et al., Milano, Italy. In J Immunol, Feb 2016
In this study, we analyze the contribution of PIP5Kβ to T cell activation and show that CD28 induces the recruitment of PIP5Kβ to the immunological synapse, where it regulates filamin A and lipid raft accumulation, as well as T cell activation, in a nonredundant manner.
Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.
Augustin et al., Heidelberg, Germany. In Dev Cell, Feb 2016
RNF213 targets filamin A and NFAT1 for proteasomal degradation attenuating non-canonical WNT/Ca(2+) signaling.
Filamin A Is Involved in HIV-1 Vpu Mediated Evasion of Host Restriction by Modulating Tetherin Expression.
Dong et al., United States. In J Biol Chem, Feb 2016
Here we report a novel role for the actin cross-linking regulator filamin A (FLNa) in Vpu anti-tetherin activities.
Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours.
Lania et al., Rozzano, Italy. In Endocr Relat Cancer, Feb 2016
Since it has been demonstrated that Filamin A (FLNA) is involved in mediating GPCR expression, membrane anchoring and signalling, we investigated the role of this cytoskeleton protein in SST2 expression and signalling, angiogenesis, cell adhesion and cell migration in human P-NETs and in QGP1 cell line.
The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response.
Hassel et al., Baltimore, United States. In Int J Mol Sci, Dec 2015
It can bind to several cytoskeletal proteins, including filamin A, an actin-binding protein that collaborates with RNase-L to maintain the cellular barrier to viral entry.
TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation.
Li et al., Guangzhou, China. In Nat Immunol, Nov 2015
Desumoylation did not affect the catalytic activity of PKC-θ but inhibited the association of CD28 with PKC-θ and filamin A and impaired the assembly of a mature immunological synapse and central co-accumulation of PKC-θ and CD28.
Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides.
Broeck et al., Stockholm, Sweden. In Cell Mol Life Sci, Nov 2015
DILP2, 3 and 5 are produced by a set of neurosecretory cells (IPCs) in the brain and their biosynthesis and release are controlled by a number of mechanisms differing between larvae and adults.
Filamin A: Insights into its Exact Role in Cancers.
Zhao et al., Beijing, China. In Pathol Oncol Res, Oct 2015
UNASSIGNED: Filamin A (FlnA) is a well-known actin cross-linking protein.
Dopamine and Somatostatin Analogues Resistance of Pituitary Tumors: Focus on Cytoskeleton Involvement.
Mantovani et al., Milano, Italy. In Front Endocrinol (lausanne), 2014
Recently, a role for cytoskeleton protein filamin A (FLNA) in DRD2 and SSTRs receptors expression and signaling in PRL- and GH-secreting tumors, respectively, has been demonstrated, first revealing a link between FLNA expression and responsiveness of pituitary tumors to pharmacological therapy.
Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling, and Importance of Interacting Proteins.
Ray, Bethesda, United States. In Prog Mol Biol Transl Sci, 2014
These processes are impacted by its interactions with several proteins in addition to signaling molecules per se (i.e., G-proteins, protein kinases, inositol phosphates, etc.) and include small molecular weight G-proteins (Sar1, Rabs, ARF, P24A, RAMPs, filamin A, 14-3-3 proteins, calmodulin, and caveolin-1).
A colorectal cancer classification system that associates cellular phenotype and responses to therapy.
Hanahan et al., Lausanne, Switzerland. In Nat Med, 2013
One of these three subtypes, identified by filamin A expression, does not respond to cetuximab but may respond to cMET receptor tyrosine kinase inhibitors in the metastatic setting.
Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.
Sheen et al., Boston, United States. In J Neurosci, 2012
Filamin A interacts with Big2 and overexpression of Filamin A interfers with neuronal migration.
A stem cell-based approach to cartilage repair.
Schultz et al., San Diego, United States. In Science, 2012
Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program.
Macrophage mesenchymal migration requires podosome stabilization by filamin A.
Maridonneau-Parini et al., Toulouse, France. In J Biol Chem, 2012
FLNa is involved in podosome stability and their organization as rosettes and three-dimensional podosomes in macrophages.
GPIbα regulates platelet size by controlling the subcellular localization of filamin.
Newman et al., Milwaukee, United States. In Blood, 2012
these data demonstrate that coordinated expression of GPIbalpha and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.
A meckelin-filamin A interaction mediates ciliogenesis.
Johnson et al., Leeds, United Kingdom. In Hum Mol Genet, 2012
Loss of filamin A expression is associated with increases in the frequency of dysmorphology and severity of ciliopathy developmental defects caused by mks3 knockdown
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
Stossel et al., Boston, United States. In Nature, 2011
Here we identify the actin-binding protein filamin A (FLNA) as a central mechanotransduction element of the cytoskeleton.
FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.
Falet et al., Boston, United States. In Blood, 2011
FlnA stabilizes the platelet von Willebrand factor receptor, as surface expression of von Willebrand factor receptor components is normal on FlnA-null MKs but decreased on FlnA-null platelets.
Polycystin-1 and -2 dosage regulates pressure sensing.
Honoré et al., Antibes, France. In Cell, 2009
Finally, we show that TRPP2 interacts with filamin A and demonstrate that this actin crosslinking protein is critical for SAC regulation.
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