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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: cytokeratin, HAD, AGE, Involucrin, IgE
Papers on Filaggrin
Filaggrin genotype and skin diseases independent of atopic dermatitis in childhood.
Melbye et al., Denmark. In Pediatr Allergy Immunol, Dec 2015
BACKGROUND: Filaggrin gene (FLG) mutations compromise skin barrier functions, and increase risk of atopic dermatitis.
Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro.
El Ghalbzouri et al., Leiden, Netherlands. In Cell Tissue Res, Sep 2015
Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.
DENND1B gene variants associate with elevated exhaled nitric oxide in healthy high-risk neonates.
Bisgaard et al., Copenhagen, Denmark. In Pediatr Pulmonol, Feb 2015
The risk factor analyses included genetic variants in DENND1B, Filaggrin, and ORMDL3; anthropometrics; demographics; socioeconomics; paternal atopy; maternal smoking, and mother's consumption of paracetamol and antibiotics during 3rd trimester; and neonatal bacterial airway colonization.
Filaggrin mutations in a Western siberian population and their association with atopic dermatitis in children.
Vavilin et al., Novosibirsk, Russia. In Genet Test Mol Biomarkers, 2014
We determined the frequencies of null mutations of the FLG gene--2282del4, R501X, R2447X, 3702delG, S3247X, and the 12-repeat allele (rs12730241)--among 460 Caucasians of the city of Novosibirsk, Russia.
Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.
Erlewyn-Lajeunesse et al., Southampton, United Kingdom. In J Allergy Clin Immunol, 2014
Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and atopy, but their association with food allergy (FA) is less clear.
Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate.
Kudoh et al., Tokyo, Japan. In J Dermatol Sci, 2014
BACKGROUND: Filaggrin (FLG) is a major protein component of the stratum corneum (SC) layer, and FLG loss-of-function mutations are a predisposing factor for atopic dermatitis (AD).
Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants.
Lack et al., London, United Kingdom. In J Invest Dermatol, 2014
Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL).
Crossing barriers; restoring barriers? Filaggrin protein replacement takes a bow.
Irvine, Dublin, Ireland. In J Invest Dermatol, 2014
In this issue of the Journal, Stout and colleagues report a novel and creative approach to replacement of genetically determined absence or deficiency of epidermal proteins.
Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes.
Hashimoto et al., Sakado, Japan. In Biosci Biotechnol Biochem, 2013
Low molecular weight soybean peptide (LSP) was applied to normal human epidermal keratinocytes, and the results showed a significant increase in the gene expression levels of involucrin, transglutaminase, and profilaggrin.
[Mouse models for spontaneous dermatitis due to impaired skin barrier formation].
Amagai et al., In Nihon Rinsho Meneki Gakkai Kaishi, 2013
We demonstrated that flaky tail mice possess loss of function mutation in Filaggrin (Flg) which is one of the major component of stratum corneum, and showed skin barrier abnormality, although our genetically engineered Flg null mice did not develop dermatitis spontaneously.
Mutations in the Filaggrin are Predisposing Factor in Korean Children With Atopic Dermatitis.
Hong et al., Seoul, South Korea. In Allergy Asthma Immunol Res, 2013
PURPOSE: Filaggrin (FLG) is a key protein that facilitates the terminal differentiation of the epidermis and the formation of the skin barrier.
Filaggrin mutations are not associated with chronic allergic keratoconjunctivitis.
Matsuda et al., In Br J Ophthalmol, 2012
Our results revealed no significant association between filaggrin mutations and chronic allergic keratoconjunctivitis.
Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies.
Kubota et al., Japan. In Am J Pathol, 2012
The decreased expression of epidermal growth factor receptor (EGFR), E-cadherin, occludin, and SIRT1 in the skin of Flg(ft) mice, compared with those in C57BL/6J mice, is reported.
Loss-of-function mutations in filaggrin gene associate with psoriasis vulgaris in Chinese population.
Xia et al., Changsha, China. In Hum Genet, 2012
study indicated that rare mutations, such as p.K4022X, in FLG gene may be associated with psoriasis in Chinese population.
Interactions between genetic variants of FLG and chromosome 11q13 locus determine susceptibility for eczema phenotypes.
Leung et al., In J Invest Dermatol, 2012
Two FLG SNPs rs11584427 and rs1933064 were in complete linkage disequilibrium
Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.
Arshad et al., Columbia, United States. In Plos One, 2011
a combination of FLG variants and allergic sensitization increased the risk of eczema in subsequent years
Extrinsic and intrinsic types of atopic dermatitis.
Tokura, Kitakyūshū, Japan. In J Dermatol Sci, 2010
Filaggrin gene mutations are not a feature of intrinsic AD.
[Atopic dermatitis - current insights into path physiology and management].
Ballmer-Weber et al., Zürich, Switzerland. In Ther Umsch, 2010
Recently, it was demonstrated that Filaggrin is a major gene for atopic eczema.
The skin's barrier.
Proksch et al., Kiel, Germany. In G Ital Dermatol Venereol, 2009
Filaggrin is cross-linked to the cornified envelope and aggregates keratin filaments into macrofibrils.
The skin: an indispensable barrier.
Jensen et al., Kiel, Germany. In Exp Dermatol, 2008
Filaggrin is cross-linked to the cornified envelope and aggregates keratin filaments into macrofibrils.
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