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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


fibromodulin, Fmod
Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Decorin, Lum, Aggrecan, CAN, HAD
Papers on fibromodulin
Effect of proteoglycans at interfaces as related to location, architecture, and mechanical cues.
Ho et al., San Francisco, United States. In Arch Oral Biol, Mar 2016
RESULTS: Immunohistochemistry (N=3) indicated presence of biglycan and fibromodulin small leucine rich proteoglycans at the interfaces.
Local trauma in human patellar tendon leads to widespread changes in the tendon gene expression.
Kjaer et al., Nottingham, United Kingdom. In J Appl Physiol, Feb 2016
Results for DNA content were inconclusive, and no changes were detected in expression of Insulin-like growth factor-I, connective tissue growth factor, scleraxis, decorin, fibromodulin, tenascin-C, tenomodulin, VEGFa, CD68, IL-6, MMP12 and MMP13.
Fibromodulin reprogrammed cells: A novel cell source for bone regeneration.
Soo et al., Los Angeles, United States. In Biomaterials, Feb 2016
Previously, we established a novel platform technology for inducing a quiescent stem cell-like stage using only a single extracellular proteoglycan, fibromodulin (FMOD), circumventing gene transduction.
Proteoglycans in liver cancer.
Kovalszky et al., Budapest, Hungary. In World J Gastroenterol, Feb 2016
This article details and discusses the roles of syndecan-1, glypicans, agrin, perlecan, collagen XVIII/endostatin, endocan, serglycin, decorin, biglycan, asporin, fibromodulin, lumican, and versican in liver function.
Gene expression profiling of prostate cancer-associated genes identifies fibromodulin as potential novel biomarker for prostate cancer.
Reyes et al., Cartagena, Colombia. In Int J Biol Markers, Jan 2016
A potential biomarker from this set of genes, the FMOD gene, encoding the small leucine-rich proteoglycan fibromodulin, was selected for further evaluation in clinical samples from patients diagnosed with benign or malignant prostatic disease.
Different responses of articular cartilage to strenuous running and joint immobilization.
Zhan et al., Fuzhou, China. In Connect Tissue Res, Jan 2016
In addition, cartilage samples were obtained to assess gene expression of aggrecan, collagen type II, biglycan and fibromodulin by quantitative RT-PCR.
The small leucine rich proteoglycan fibromodulin is overexpressed in human prostate epithelial cancer cell lines in culture and human prostate cancer tissue.
Geliebter et al., Cartagena, Colombia. In Cancer Biomark, Dec 2015
BACKGROUND: Fibromodulin is a small leucine-rich proteoglycan important for extracellular matrix organization and essential for tissue repair in multiple organs.
The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis.
Chakravarti et al., Lund, Sweden. In J Intern Med, Nov 2015
We focus on five SLRPs, decorin, biglycan, lumican, fibromodulin and PRELP, because these have been detected in atherosclerotic plaques or demonstrated to have a role in animal models of atherosclerosis.
Genome-wide scan for selection signatures in six cattle breeds in South Africa.
Maiwashe et al., South Africa. In Genet Sel Evol, 2014
In addition, a number of candidate genes associated with the nervous system (WNT5B, FMOD, PRELP, and ATP2B), immune response (CYM, CDC6, and CDK10), production (MTPN, IGFBP4, TGFB1, and AJAP1) and reproductive performance (ADIPOR2, OVOS2, and RBBP8) were also detected as being under selection.
Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction.
Hultström et al., Bergen, Norway. In Plos One, 2014
25 genes were upregulated in Mmp2+/+ OK compared to Mmp2+/+ CL: Adamts1, -2, Col1a1, -2, -3a1, -4a1, -5a1, -5a2, Dcn, Fbln1, -5, Fmod, Fn1, Itga2, Loxl1, Mgp, Mmp2, -3, Nid1, Pdgfb, Spp1, Tgfb1, Timp2, Trf, Vim.
Soluble biglycan as a biomarker of inflammatory renal diseases.
Schaefer et al., Frankfurt am Main, Germany. In Int J Biochem Cell Biol, 2014
Finally, we will critically evaluate the potential application of soluble biglycan vis-à-vis other SLRPs (decorin, lumican and fibromodulin) as a promising target and novel biomarker of inflammatory renal diseases.
Proteoglycans and diseases of soft tissues.
Halper, Athens, United States. In Adv Exp Med Biol, 2013
Several members of Class I and II, such as decorin and biglycan from Class I, and Class II fibromodulin and lumican, are known to regulate collagen fibrillogenesis.
The role of lumican in ocular disease.
Wakefield et al., Sydney, Australia. In Isrn Ophthalmol, 2012
Lumican deficiency in mice results in increased axial length with fibromodulin deficiency and thinner sclerae.
Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.
Nieto et al., New York City, United States. In Gastroenterology, 2012
Hepatic fibromodulin activates hepatic stellate cells and promotes collagen I deposition, which leads to liver fibrosis.
Role of subchondral bone during early-stage experimental TMJ osteoarthritis.
Young et al., Bethesda, United States. In J Dent Res, 2011
critical for temporomandibular joint subchondral bone integrity
Lectin affinity chromatography of articular cartilage fibromodulin: Some molecules have keratan sulphate chains exclusively capped by α(2-3)-linked sialic acid.
Nieduszynski et al., Lancaster, United Kingdom. In Glycoconj J, 2011
There are discrete populations of fibromodulin within articular cartilage, which may have differing impacts upon tissue processes.
Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth: a micro-CT time course study.
Young et al., Paris, France. In Cells Tissues Organs, 2010
The differential effects of Fmod deficiency on bones and teeth appear to diverge in adult mice.
Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint.
Fujita et al., Wakayama, Japan. In Eur J Histochem, 2010
lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta.
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche.
Young et al., Bethesda, United States. In Nat Med, 2007
Moreover, we show that TSPCs reside within a unique niche predominantly comprised of an extracellular matrix, and we identify biglycan (Bgn) and fibromodulin (Fmod) as two critical components that organize this niche.
Negative regulation of transforming growth factor-beta by the proteoglycan decorin.
Ruoslahti et al., Los Angeles, United States. In Nature, 1990
Similar repeats have been found in two other proteoglycans, biglycan and fibromodulin, and in several other proteins including Drosophila morphogenetic proteins.
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