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Fibroblast growth factor 10

Fibroblast Growth Factor 10, FGF10
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: keratinocyte growth factor, CAN, FGFR2, Fibroblast Growth Factor 2, V1a
Papers on Fibroblast Growth Factor 10
Mechanisms of fibroblast growth factor signaling in the ovarian follicle.
Price, Saint-Hyacinthe, Canada. In J Endocrinol, Feb 2016
Other FGFs have also been implicated in ovarian function, and this review summarizes the effects of members of two subfamilies on ovarian function; the FGF7 subfamily that also contains FGF10, and the FGF8 subfamily that also contains FGF18.
Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation.
Fukumoto et al., Fukuoka, Japan. In J Biol Chem, Feb 2016
The expression of Pdgfa, Pdgfb, Fgf7, and Fgf10, which induced branching of SMGs in Cx43(-/-) samples, were not changed as compared with those from heterozygotes.
Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions.
Ieda et al., Tokyo, Japan. In Stem Cell Reports, Jan 2016
Here, we report that a combination of fibroblast growth factor (FGF) 2, FGF10, and vascular endothelial growth factor (VEGF), termed FFV, promoted cardiac reprogramming under defined serum-free conditions, increasing spontaneously beating iCMs by 100-fold compared with those under conventional serum-based conditions.
Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development.
Bellusci et al., Los Angeles, United States. In Development, Jan 2016
This is accompanied by significant upregulation, in the lung mesenchyme, of peroxisome proliferator-activated receptor gamma (master switch of lipogenesis), adipose differentiation-related protein (marker of mature lipofibroblasts) and fibroblast growth factor 10 (previously shown to identify a subpopulation of lipofibroblast progenitors).
Comparative study on the differentiation of mesenchymal stem cells between fetal and postnatal rat spinal cord niche.
Yuan et al., Shenyang, China. In Cell Transplant, Dec 2015
In addition, we found that the expression of brain-derived neurotrophic factor (BDNF), NT-3, FGF-8, TGF-α, epidermal growth factor (EGF), and insulin-like growth factor (IGF) decreased with age, and the expression of FGF-2, FGF-10, FGF-20, TGF-α, and PDGF increased with age.
FGF10: A multifunctional mesenchymal-epithelial signaling growth factor in development, health, and disease.
Itoh, Kyoto, Japan. In Cytokine Growth Factor Rev, Dec 2015
FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co-factor.
The Roles of Growth Factors in Keratinocyte Migration.
Paller et al., Chicago, United States. In Adv Wound Care (new Rochelle), May 2015
This review will highlight the growth factors, particularly transforming growth factor-α (TGF-α), heparin-binding epidermal growth factor (HB-EGF), insulin-like growth factor 1 (IGF-1), fibroblast growth factor 7 (FGF-7), FGF-10, and hepatocyte growth factor (HGF), which have conclusively been shown to be the most motogenic for KCs.
Harnessing the potential of lung stem cells for regenerative medicine.
Laurent et al., Melbourne, Australia. In Int J Biochem Cell Biol, 2014
We also discuss the role of mesenchymal progenitor cells in maintaining the structural integrity of the lung and propose a model in which mesenchymal cells act as the quintessential architects of lung regeneration by providing molecular signals, such as FGF-10, to regulate the fate and specificity of epithelial stem and progenitor cells.
Hereditary disorders affecting the lacrimal system.
Allen, Iowa City, United States. In Curr Opin Ophthalmol, 2014
These disorders can be categorized into the following groups: fibroblast growth factor 10 associated disorders, tumor protein p63 associated disorders, disorders associated with the development of the branchial apparatus, and disorders associated with autonomic dysfunction.
Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury.
Bellusci et al., Gießen, Germany. In Scientifica (cairo), 2013
During the past 18 years, Fgf10 has emerged not only as a marker for the distal lung mesenchyme during early lung development, but also as a key player in branching morphogenesis and a critical component of the niche for epithelial stem cells.
FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.
Bellusci et al., Los Angeles, United States. In Dev Biol, 2012
Using tissue specific Fgf9 versus Pitx2 loss of function approaches in the gut epithelium and/or mesenchyme, we determined that FGF9 signals to the mesenchyme via Pitx2 to induce mesenchymal Fgf10 expression, which leads to epithelial cecal bud formation.
A Sox9/Fgf feed-forward loop maintains pancreatic organ identity.
Sander et al., San Diego, United States. In Development, 2012
Results demonstrate that organ fate commitment and progenitor cell expansion are coordinately controlled by the activity of a Sox9/Fgf10/Fgfr2b feed-forward loop in the pancreatic niche.
Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development.
Zhang et al., Indianapolis, United States. In Development, 2012
GAG controls lacrimal gland induction by restricting the diffusion of Fgf10
FGF10 inhibits dominant follicle growth and estradiol secretion in vivo in cattle.
Gonçalves et al., Rio Grande, Brazil. In Reproduction, 2012
FGF10 and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 acts as an important regulator of follicular growth in cattle.
Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver.
Stainier et al., San Francisco, United States. In Mech Dev, 2012
fgf10a, which is expressed in the mesenchyme surrounding non-hepatic endodermal cells, negatively impacts the regulative capacity of endodermal tissues.
Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.
Martin et al., San Francisco, United States. In Science, 2011
We identify sprouty genes, which encode negative regulators of fibroblast growth factor 10 (FGF10)-mediated RAS-regulated ERK1/2 signaling, as essential for controlling airway shape change during development through an effect on mitotic spindle orientation.
Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation.
Witte et al., Los Angeles, United States. In Cell Stem Cell, 2011
In an in vivo prostate regeneration system, Bmi-1 inhibition protects prostate cells from FGF10-driven hyperplasia and slows the growth of aggressive Pten-deletion-induced prostate cancer.
Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.
Witte et al., Los Angeles, United States. In Cancer Cell, 2007
Stromal FGF10 expression may facilitate the multifocal histology observed in prostate adenocarcinoma.
Fgf10 regulates hepatopancreatic ductal system patterning and differentiation.
Stainier et al., San Francisco, United States. In Nat Genet, 2007
Fgf10 signaling from the adjacent mesenchyme is responsible for refining the boundaries
Mutations in different components of FGF signaling in LADD syndrome.
Wollnik et al., Köln, Germany. In Nat Genet, 2006
We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3) in LADD families, and in one further LADD family, we detected a mutation in the gene encoding fibroblast growth factor 10 (FGF10), a known FGFR ligand.
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