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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Formin-like 3

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, DAAM2, FRL, DAAM1, ACID
Papers on FHOD3
An integrated analysis of cancer genes in thyroid cancer.
Lv et al., Shanghai, China. In Oncol Rep, Feb 2016
Two genes, FHOD3 and SRP72, were hypomethylated, overexpressed and involved in major deletions in thyroid cancer.
Cell type-dependent mechanisms for formin-mediated assembly of filopodia.
Higgs et al., Hannover, Germany. In Mol Biol Cell, Jan 2016
We test this model using constitutively active constructs of two formins, FMNL3 and mDia2.
α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.
Caswell et al., Manchester, United Kingdom. In J Cell Biol, Oct 2015
Dynamic actin spike assembly in cells invading in vitro and in vivo is regulated by Formin homology-2 domain containing 3 (FHOD3), which is activated by RhoA/ROCK, establishing a novel mechanism through which the RCP-α5β1 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin.
Mellor et al., Bristol, United Kingdom. In Curr Biol, Oct 2015
In our previous work, we showed that the cytoskeletal regulator FMNL3/FRL2 controls the alignment of stabilized microtubules during polarized endothelial cell elongation and that depletion of FMNL3 retards elongation of the intersegmental vessels in zebrafish.
Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder.
Gecz et al., Adelaide, Australia. In Hum Mol Genet, May 2015
Considering other modes of inheritance, we also found compound heterozygous variants in FMNL3 (c.114G>C, p.Phe38Leu and c.1372T>G, p.Ile458Leu [CCDS44874.1])
Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma.
Xin et al., Nanchang, China. In Exp Mol Pathol, Apr 2015
Formin-like 3 (FMNL3), a member of diaphanous-related formins subfamily, plays an important role in cytoskeleton reorganization, cell adhesion and cancer cell invasion in vitro.
The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.
Higgs et al., Hannover, Germany. In Mol Biol Cell, Mar 2015
FMNL3 is a vertebrate-specific formin protein previously shown to play a role in angiogenesis and cell migration.
Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres.
Mannherz et al., Bochum, Germany. In Eur J Cell Biol, Feb 2015
Two polyclonal antibodies against FHOD1 were generated against (i) its N-terminal sequence (residues 1-339) and (ii) a peptide corresponding the sequence from position 358-371, which is unique for FHOD1 and does not occur in its close relative FHOD3.
The formin FHOD1 in cardiomyocytes.
Ehler et al., London, United Kingdom. In Anat Rec (hoboken), 2014
We have recently identified a muscle specific splice variant of the formin FHOD3 and demonstrated its role in the maintenance of the contractile filaments of cardiomyocytes.
Whole-genome analysis in Korean patients with autoimmune myasthenia gravis.
Choi et al., Taejŏn, South Korea. In Yonsei Med J, 2014
From regional analysis, we selected seven candidate genes (RYR3, CACNA1S, SLAMF1, SOX5, FHOD3, GABRB1, and SACS) for further analysis.
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
Marazita et al., Pittsburgh, United States. In G3 (bethesda), 2014
Moreover, we nominated novel loci not previously implicated in chronic periodontitis or related pathways, including the regions 3p22 near OSBPL10 (a lipid receptor implicated in hyperlipidemia), 4p15 near HSP90AB2P (a heat shock pseudogene), 11p15 near GVINP1 (a GTPase pseudogene), 14q31 near SEL1L (an intracellular transporter), and 18q12 in FHOD3 (an actin cytoskeleton regulator).
Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy.
Huggins et al., Boston, United States. In Circ Cardiovasc Genet, 2013
We identified an intronic FHOD3 variant (rs516514) associated with HCM (odds ratio, 2.45; 95% confidence interval, 1.76-3.41;
MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation.
Tazi et al., Montpellier, France. In Nat Commun, 2012
These critical splicing adjustments arise early in vertebrate evolution and remain fixed in at least 10 genes (including PLOD2, CLSTN1, ATP2A1, PALM, ITGA6, KIF13A, FMNL3, PPIP5K1, MARK2 and FNIP1), implying that vertebrates require alternative splicing to fully implement the instructions of transcriptional control networks.
Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.
Bray et al., Dublin, Ireland. In Plos One, 2012
We demonstrate that miR-335 regulates the expression of at least five formin family members and validate three family members, FMNL3, FMN2 and DAAM2, as direct targets of miR-335.
Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor.
Kimura et al., Tokyo, Japan. In Circ J, 2012
Formin homology 2 domain containing 3 (FHOD3) is a sarcomeric protein expressed in the heart that plays an essential role in sarcomere organization during myofibrillogenesis.
Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart.
Sumimoto et al., Fukuoka, Japan. In Plos One, 2011
embryonic heart of mice specifically expresses the Fhod3 mRNA isoform harboring the three alternative exons
Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3.
Utsumi et al., Yamaguchi, Japan. In Biosci Biotechnol Biochem, 2011
Protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3.
Assembly of filopodia by the formin FRL2 (FMNL3).
Higgs et al., Stanford, United States. In Cytoskeleton (hoboken), 2010
Data suggest that the FH2 domain of FRL2 possesses properties not shared by FRL1 that allow it to generate filopodia.
Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles.
Sumimoto et al., Fukuoka, Japan. In J Biol Chem, 2009
actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells.
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
Relling et al., Memphis, United States. In Blood, 2009
Single nucleotide polymorphism in FHOD3 gene is associated with acute lymphoblastic leukemia.
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