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Four and a half LIM domains 1

FHL1, Slim, SLIM1
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: LIM, CAN, HAD, ACID, AGE
Papers using FHL1 antibodies
Phylogenetic motif detection by expectation-maximization on evolutionary mixtures.
Wolfe Kenneth H., In PLoS Biology, 2003
... Protein interaction assays were done with fragments of Fhl1 and Ifh1 cloned by PCR in the Yeast-two hybrid plasmids pGADT7 and pGBKT7 between SfiI and XmaI (Clontech Laboratories Inc.) ...
Papers on FHL1
Preservation of cochlear structures and hearing when using the Nucleus Slim Straight (CI422) electrode in children.
Skarzynski et al., Warsaw, Poland. In J Laryngol Otol, Feb 2016
This study aimed to evaluate hearing preservation in children implanted with the Nucleus Slim Straight (CI422) electrode.
Central and peripheral defects in motor units of the diaphragm of spinal muscular atrophy mice.
Schümperli et al., Bern, Switzerland. In Mol Cell Neurosci, Jan 2016
These are apoptosis inducing factor 1 (AIFM1), a mitochondrial flavoprotein that initiates apoptosis in a caspase-independent pathway, and four and a half Lim domain protein 1 (FHL1), a regulator of skeletal muscle mass that has been implicated in several myopathies.
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies.
Lundberg et al., In J Clin Invest, Jan 2016
Mutations of the gene encoding four-and-a-half LIM domain 1 (FHL1) are the causative factor of several X-linked hereditary myopathies that are collectively termed FHL1-related myopathies.
The FHL2 regulation in the transcriptional circuitry of human cancers.
Tsui et al., Hong Kong, Hong Kong. In Gene, Dec 2015
Five members have been categorized into the FHL subfamily, which are FHL1, FHL2, FHL3, FHL4 and activator of CREM in testis (ACT) in human.
Evaluation of a Voluntary Worksite Weight Loss Program on Metabolic Syndrome.
Church et al., Dallas, United States. In Metab Syndr Relat Disord, Nov 2015
METHODS: Participants (N = 3880, from 93 companies) volunteered within their workplaces to participate in a 10-week weight loss program (Naturally Slim) focused on self-monitoring, eating behaviors, understanding hunger signals, reducing refined carbohydrate and sugar intake, and increasing protein intake to 25%-30%.
Mitochondrial abnormalities in the myofibrillar myopathies.
Reichmann et al., Dresden, Germany. In Eur J Neurol, Nov 2015
Causative mutations have been identified in the genes MYOT, LDB3, DES, CRYAB, FLNC, BAG3, DNAJB6, FHL1, PLEC and TTN, which encode proteins which either reside in the Z-disc or associate with the Z-disc.
Myofibrillar myopathies: State of the art, present and future challenges.
Eymard et al., Paris, France. In Rev Neurol (paris), Oct 2015
The boundaries of this concept are still uncertain, and whereas six genes (DES, CRYAB, LDB3/ZASP, MYOT, FLNC and BAG3) are now classically considered as responsible for MFM, other entities such as FHL1 myopathy or Hereditary Myopathy with Early Respiratory Failure linked to mutations of titin can now as well be included in this group.
[FHL1 knockdown mediated by lentiviral shRNA promotes the growth of HeLa and HepG2 cells].
Jiao et al., Beijing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Jul 2015
OBJECTIVE: To investigate the effect of four-and-a-half LIM domain 1 (FHL1) knockdown by lentiviral-mediated shRNA on the growth of HeLa and HepG2 cells.
[PDLIM2 and Its Role in Oncogenesis--Tumor Suppressor or Oncoprote?].
Bouchal et al., In Klin Onkol, 2014
PDZ and LIM domain containing protein 2 (PDLIM2), also known as Mystique or SLIM, is a member of the actinin-associated LIM family of proteins that play essential roles in cytoskeletone organization, cell differentiation and have been associated with oncogenesis.
Links Between Ethylene and Sulfur Nutrition-A Regulatory Interplay or Just Metabolite Association?
Sirko et al., Warsaw, Poland. In Front Plant Sci, 2014
Regulatory links of EIN3 and SLIM1 (both from the same family of transcriptional factors) involved in the regulation of ethylene and sulfur pathway, respectively, is also quite probable as well as the reciprocal modulation of both pathways on the enzyme activity levels.
Transcriptator: An Automated Computational Pipeline to Annotate Assembled Reads and Identify Non Coding RNA.
Guarracino et al., Napoli, Italy. In Plos One, 2014
The implementation of QuickGo web-services in our pipeline enable the users to carry out GO-Slim analysis, whereas the integration of PORTRAIT (Prediction of transcriptomic non coding RNA (ncRNA) by ab initio methods) helps to identify the non coding RNAs and their regulatory role in transcriptome.
FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy.
Kemp et al., London, United Kingdom. In Febs Open Bio, 2014
In cancer cells, TGFβ signalling is increased by the protein FHL1.
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Sheikh et al., San Diego, United States. In J Biol Chem, 2012
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Fhl1 as a downstream target of Wnt signaling to promote myogenesis of C2C12 cells.
Lee et al., Taiwan. In Mol Cell Biochem, 2012
Wnt signaling induces muscle cell differentiation, at least partly, through Fhl1 activation.
Expression of FHL1 in gastric cancer tissue and its correlation with the invasion and metastasis of gastric cancer.
Guo et al., Shenyang, China. In Mol Cell Biochem, 2012
The decrease in or loss of FHL1 expression may be related to the incidence, progression, invasiveness, and metastatic potential of gastric cancer.
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
Semenza et al., Baltimore, United States. In J Biol Chem, 2012
FHL1-3 inhibit HIF-1 transcriptional activity and HIF-1alpha transactivation domain function by oxygen-independent mechanisms.
PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3.
Matsuda et al., Yokohama, Japan. In Sci Signal, 2010
Deficiency in PDLIM2 resulted in the accumulation of STAT3 in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation.
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling.
Grusby et al., Boston, United States. In Immunity, 2005
SLIM is a novel ubiquitin E3 ligase whose targets include STAT proteins.
Ribosome biogenesis: giant steps for a giant problem.
Powers, Davis, United States. In Cell, 2005
In this issue of Cell, the Hall group describes how the rapamycin-sensitive TOR signaling network controls ribosomal protein (RP) gene expression via the Forkhead-like transcription factor FHL1 in budding yeast (Martin et al., 2004).
TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.
Hall et al., Basel, Switzerland. In Cell, 2005
FHL1 is involved in the target of rapamycin (TOR)-protein kinase A regulated transcription of Ribosomal protein gene in yeast.
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