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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

FHIT fragile histidine triad gene

Top mentioned proteins: HAD, p53, POLYMERASE, p16, CAN
Papers on FHIT
Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse.
Huebner et al., Nagasaki, Japan. In Cancer Sci, Feb 2016
UNASSIGNED: Loss of expression of Fhit, a tumor suppressor and genome caretaker, occurs in preneoplastic lesions during development of many human cancers.
Integrated genomic analysis of pancreatic ductal adenocarcinomas reveals genomic rearrangement events as significant drivers of disease.
Vasmatzis et al., United States. In Cancer Res, Jan 2016
SMAD4, ZNF521, and FHIT were among the most frequently hit genes.
[DNA methylation and telomere damage in occupational people exposed to coal tar pitch].
Wu et al., Anyang, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, Jul 2015
OBJECTIVE: To investigate the promoter methylation of p16, FHIT and RASSF1A gene and telomere damage in the workers exposed to coal tar pitch, and to explore the effective biomarker of occupational exposure to coal tar pitch.
WWOX, large common fragile site genes, and cancer.
Smith et al., Rochester, United States. In Exp Biol Med (maywood), Mar 2015
Two other highly unstable CFSs, FRA3B (3p14.2) and FRA6E (6q26), also span extremely large genes, FHIT and PARK2, respectively, and these two genes are also found to be important tumor suppressors.
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism.
Ma et al., Wuhan, China. In Nat Genet, Feb 2015
Beyond recalculating frequencies for the previously reported frequent integration sites POU5F1B (9.7%), FHIT (8.7%), KLF12 (7.8%), KLF5 (6.8%), LRP1B (5.8%) and LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and SEMA3D (4.9%).
Very large common fragile site genes and their potential role in cancer development.
Smith et al., Rochester, United States. In Cell Mol Life Sci, 2014
The three most frequently expressed CFS regions (FRA3B, FRA16D and FRA6E) contain genes that span extremely large genomic regions (FHIT, WWOX and PARK2, respectively), and these genes were found to function as important tumor suppressors.
The FHIT gene product: tumor suppressor and genome "caretaker".
Huebner et al., Columbus, United States. In Cell Mol Life Sci, 2014
The FHIT gene at FRA3B is one of the earliest and most frequently altered genes in the majority of human cancers.
The clinicopathological significance and drug target potential of FHIT in breast cancer, a meta-analysis and literature review.
Xu et al., Wuhan, China. In Drug Des Devel Ther, 2014
FHIT is a bona fide tumor-suppressor gene and its loss contributes to tumorigenesis of epithelial cancers including breast cancer (BC).
FHIT Gene Expression in Acute Lymphoblastic Leukemia and its Clinical Significance.
Elbossaty et al., Damietta, Egypt. In Asian Pac J Cancer Prev, 2014
BACKGROUND: To investigate the expression of the fragile histidine triad (FHIT) gene in acute lymphoblastic leukemia and its clinical significance.
Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers.
Harrison et al., Edinburgh, United Kingdom. In Plos One, 2014
Frequently gained regions contained EGFR, PIK3CA, MYC, SMO, TRIB1, FZD1, and BRCA2, while frequently lost regions contained FHIT and MACROD2.
DNA methylation-based biomarkers in bladder cancer.
Zwarthoff et al., Rotterdam, Netherlands. In Nat Rev Urol, 2013
Indeed, several studies have revealed that methylated genes--including CDH1, FHIT, LAMC2, RASSF1A, TIMP3, SFRP1, SOX9, PMF1 and RUNX3--are associated with poor survival in patients with MIBC.
Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH).
Ferretti et al., Pavia, Italy. In Cytogenet Genome Res, 2007
the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors
The DNA sequence, annotation and analysis of human chromosome 3.
Gibbs et al., Houston, United States. In Nature, 2006
It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B.
Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer.
Kim et al., Seoul, South Korea. In J Clin Oncol, 2004
Aberrant methylation at the promoters of the p16, Ras association domain family 1A (RASSF1A), fragile histidine triad (FHIT), H-cadherin, and retinoic acid receptor beta (RARbeta) genes were evaluated in the resected tumor tissues and bronchial lavage samples of NSCLC patients and in the bronchial lavage samples of cancer-free subjects by methylation-specific polymerase chain reaction.
Chromosome arm 8p and cancer: a fragile hypothesis.
Chaffanet et al., Marseille, France. In Lancet Oncol, 2003
Some fragile sites lie within genes that may have a role in cancer; the best example is FHIT at 3p14, which contains the fragile site FRA3B.
FHIT: from gene discovery to cancer treatment and prevention.
Croce et al., United States. In Lancet Oncol, 2002
6 years ago, the FHIT gene was identified in this region.
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