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Fibrinogen gamma chain

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, POLYMERASE, ACID, AGE
Papers on FGG
[Analysis of molecular pathogenesis and clinical phenotypes in 10 probands with inherited fibrinogen deficiency].
Wang et al., Wenzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Jan 2016
CONCLUSION: Mutations of the Fg gene seem to aggregate to the D region of FGG in our region, and Arg275 is a common mutation.
Differences in the function and secretion of congenital aberrant fibrinogenemia between heterozygous γD320G (Okayama II) and γΔN319-ΔD320 (Otsu I).
Okumura et al., Matsumoto, Japan. In Thromb Res, Dec 2015
RESULTS: A heterozygous A>G in FGG, resulting in γ320Asp>Gly for Okayama II, and a heterozygous deletion of AATGAT in FGG, resulting in the deletion of γAsn319 and γAsp320 (γΔN319-ΔD320) for Otsu I, were obtained.
Aestivation induces changes in transcription and translation of coagulation factor II and fibrinogen gamma chain in the liver of the African lungfish Protopterus annectens.
Ip et al., Singapore, Singapore. In J Exp Biol, Dec 2015
This study aimed to sequence and characterize two pro-coagulant genes, coagulation factor II (f2) and fibrinogen gamma chain (fgg), from the liver of the African lungfish Protopterus annectens, and to determine their hepatic mRNA expression levels during three phases of aestivation.
Fibrinogen storage disease and cirrhosis associated with hypobetalipoproteinemia owing to fibrinogen Aguadilla in a Turkish child.
Callea et al., Ankara, Turkey. In Liver Int, Dec 2015
Herein, we report on the first Turkish family carrying the mutation p.Arg375Trp (fibrinogen Aguadilla) in the γ-chain of the fibrinogen (FGG) gene.
Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum.
Chen et al., Tianjin, China. In Cancer Biol Med, Sep 2015
Three differential glycoproteins, namely, fibrinogen gamma chain (FGG), FOS-like antigen 2 (FOSL2), and α-1,6-mannosylglycoprotein 6-β-N-acetylglucosaminyltransferase B (MGAT5B) were validated by Western blot.
Hepatic fibrinogen storage disease: identification of two novel mutations (p.Asp316Asn, fibrinogen Pisa and p.Gly366Ser, fibrinogen Beograd) impacting on the fibrinogen γ-module.
Duga et al., Milano, Italy. In J Thromb Haemost, Aug 2015
Their genetic basis is invariably represented by mutations within the fibrinogen genes (FGA, FGB and FGG coding for the Aα, Bβ and γ chains).
Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.
Freedman et al., Boston, United States. In Plos One, 2014
Genes, such as Serpina1a, Ttr, Fgg, Rpl21, and Alb, were uniquely affected by infection and diet.
Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells.
Mat Junit et al., Kuala Lumpur, Malaysia. In Peerj, 2014
The expression of KNG1, SERPINC1, SERPIND1, SERPINE1, FGG, FGA, MVK, DHCR24, CYP24A1, ALDH6A1, EPHX1 and LEAP2 were amongst the highly regulated.
Impaired Activity of Blood Coagulant Factor XIII in Patients with Necrotizing Enterocolitis.
Sylvester et al., Stanford, United States. In Sci Rep, 2014
We observed significant impairment in the formation of fibrinogen-γ dimers (FGG-dimer) in the plasma of newborns with NEC that could efficiently differentiate NEC and sepsis with a high level of sensitivity and specificity.
A novel fibrinogen γ chain frameshift deletion (c.637delT) in a patient with hypodysfibrinogenemia associated with thrombosis.
Oldenburg et al., Bonn, Germany. In Hamostaseologie, 2014
A novel deletion in FGG gene (c.637delT)
Fibrinogen gene regulation.
Neerman-Arbez et al., Genève, Switzerland. In Thromb Haemost, 2012
The fibrinogen genes (FGB-FGA-FGG) are expressed almost exclusively in hepatocytes where their output is coordinated to ensure a sufficient mRNA pool for each chain and maintain an abundant plasma fibrinogen protein level.
Fibrinogen residue γAla341 is necessary for calcium binding and 'A-a' interactions.
Lord et al., Seoul, South Korea. In Thromb Haemost, 2012
Fibrinogen residue gammaAla341 is important for the proper conformation of the gamma-module, maintaining calcium-binding site and 'A-a' interactions.
Mechanism of fibrin(ogen) forced unfolding.
Barsegov et al., Lowell, United States. In Structure, 2011
mechanical unraveling of fibrin(ogen) is determined by the combined molecular transitions that couple stepwise unfolding of the gamma chain nodules and reversible extension-contraction of the alpha-helical coiled-coil connectors
Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.
Farrell et al., Springfield, United States. In Arterioscler Thromb Vasc Biol, 2011
gamma' fibrinogen is associated with prevalent cardiovascular disease and with SNPs exclusively in and near the fibrinogen gene locus.
ICAM1 and fibrinogen-γ are increased in uterine epithelial cells at the time of implantation in rats.
Murphy et al., Sydney, Australia. In Mol Reprod Dev, 2011
FGG dimerization increased on day 6 of pregnancy, dependent on the presence of a developing blastocyst
Correlation of D dimer and factor VIII levels with histopathology in patients with breast carcinoma.
Khurana et al., Delhi, India. In Cancer Biomark, 2009
Data show that D-dimer and factor VIII may be used as yardstick for systemic adjuvant therapy in node negative < 1 cm breast cancer.
A novel frameshift mutation in FGA accounting for congenital afibrinogenemia predicted to encode an aberrant peptide terminating 158 amino acids downstream.
Neerman-Arbez et al., Genève, Switzerland. In Blood Coagul Fibrinolysis, 2009
Many causative mutations have been described to date in all three fibrinogen genes, most of them in the fibrinogen A alpha-chain gene (FGA), but also in the fibrinogen B beta-chain gene (FGB) and the fibrinogen gamma-chain gene (FGG).
Genetic polymorphisms for the study of multifactorial stroke.
Candelise et al., Milano, Italy. In Hum Mutat, 2008
We evaluated a number of studies on several candidate genes (including F5, F2, FGA/FGB/FGG, F7, F13A1, vWF, F12, SERPINE1, ITGB3/PLA1/PLA2/ITGA2B, ITGA2, GP1BA, ACE, AGT, NOS3, APOE, LPL, PON1, PDE4D, ALOX5AP, MTHFR, MTR, and CBS), providing a final panel of genes and molecular variants.
Molecular mechanisms accounting for fibrinogen deficiency: from large deletions to intracellular retention of misfolded proteins.
Neerman-Arbez et al., Genève, Switzerland. In J Thromb Haemost, 2007
Each polypeptide is encoded by a distinct gene, FGA, FGB and FGG, all three clustered in a region of 50 kb on 4q32.
Molecular genetics of quantitative fibrinogen disorders.
Tenchini et al., Milano, Italy. In Cardiovasc Hematol Agents Med Chem, 2007
Three genes (FGA, FGB, and FGG) clustered on chromosome 4q31.3-4q32.1 encode the three polypeptide chains (Aalpha, Bbeta, and gamma), which in a pairwise fashion form the hexameric circulating molecule.
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