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FGFR1 oncogene partner

FGFR1OP, FGFR1 oncogene partner, fibroblast growth factor receptor 1 oncogene partner
This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FGFR1, CAN, ZNF198, BCR, POLYMERASE
Papers on FGFR1OP
Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.
Minucci et al., Milano, Italy. In Mol Oncol, 2014
Recently, a RET (exon 12) rearrangement with FGFR1OP [fibroblast growth factor receptor 1 (FGFR1) oncogene partner] (exon 12) was identified in one chronic myelomonocytic leukemia (CMML) patient.
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Song et al., Seoul, South Korea. In Gut, 2014
RESULTS: We confirmed four previously reported loci: TNFSF15, IL23R, the major histocompatibility complex region, and the RNASET2-FGFR1OP-CCR6 region.
Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells.
Peters et al., Madison, United States. In Mol Cell Proteomics, 2013
Five of these proteins (PDLIM1, FGFR1OP, leiomodin-1, ZO-2 and LRP16A) were only detected in DEX-treated cells by MS.
FOP is a centriolar satellite protein involved in ciliogenesis.
Stearns et al., Stanford, United States. In Plos One, 2012
FOP (FGFR1 Oncogene Partner) is a known centrosome protein with homology to the centriolar satellite proteins FOR20 and OFD1.
FGFR1OP tagSNP but not CCR6 polymorphisms are associated with Vogt-Koyanagi-Harada syndrome in Chinese Han.
Yang et al., Chongqing, China. In Plos One, 2012
BACKGROUND: Polymorphisms of the CC chemokine receptor 6 (CCR6) and FGFR10P tagSNP (locus close to CCR6) at 6q27 have recently been reported to be associated with the susceptibility to several immune-related diseases.
RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation.
Delabesse et al., Paris, France. In Leukemia, 2012
We report here the cloning and functional characterization of two novel fusion genes BCR-RET and FGFR1OP-RET in chronic myelomonocytic leukemia (CMML) cases generated by two balanced translocations t(10;22)(q11;q11) and t(6;10)(q27;q11), respectively.
The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein.
Wiedlocha et al., Oslo, Norway. In Cell Signal, 2011
The KG-1a cell line is developed from a human stem cell myeloproliferative neoplasm as the result of intragenic disruption and a chromosomal translocation of the FGFR1 gene and the FGFR1OP2 gene encoding a protein of unknown function called FOP2 (FGFR1 Oncogene Partner 2).
A genome-wide association study identifies two new risk loci for Graves' disease.
China Consortium for Genetics of Autoimmune Thyroid Disease et al., Shanghai, China. In Nat Genet, 2011
We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)).
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Osman et al., New York City, United States. In Cancer Res, 2011
We identified 8 genes (DIS3, FGFR1OP, G3BP2, GALNT7, MTAP, SEC23IP, USO1, and ZNF668) in which NM/SSM-specific copy number alterations correlated with differential gene expression (P < 0.05; Spearman's rank).
Myeloproliferative disorders with t(8;9)(p12;q33): a case report and review of the literature.
He et al., Suzhou, China. In Pediatr Hematol Oncol, 2011
The most frequent partner genes are in decreasing order of frequency: ZNF198 (or ZMYM2, zinc finger MYM type 2), CEP110 (centrosomal protein 110 kDa), FOP (or FGFR1OP, FGFR1 [fibroblast growth factor receptor 1] oncogene partner), and BCR (breakpoint cluster region) located on 13q12, 9q33, 6q27, and 22q11, respectively.
Using regulatory and epistatic networks to extend the findings of a genome scan: identifying the gene drivers of pigmentation in merino sheep.
Kijas et al., Brisbane, Australia. In Plos One, 2010
Further, we report a number of differentially expressed genes in regions containing highly associated SNP including ATRN, DOCK7, FGFR1OP, GLI3, SILV and TBX15.
Wound closure and wound management: A new therapeutic molecular target.
Nishimura et al., Los Angeles, United States. In Cell Adh Migr, 2010
also known as fibroblast growth factor receptor 1 oncogene partner 2 (FGFR1OP2), can significantly modulate fibroblast-driven wound closure in vitro and in vivo.
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
Zhang et al., Hefei, China. In Nat Genet, 2010
OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6.
Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.
Nishimura et al., Los Angeles, United States. In Am J Pathol, 2010
also known as fibroblast growth factor receptor 1 oncogene partner 2 (FGFR1OP2).
Proteome changes in platelets activated by arachidonic acid, collagen, and thrombin.
Dyr et al., Praha, Czech Republic. In Proteome Sci, 2009
Five proteins were found that had not previously been identified in platelets: protein CDV3 homolog, protein ETHE1, protein LZIC, FGFR1 oncogene partner 2, and guanine nucleotide-binding protein subunit beta-5.
Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.
Daigo et al., Tokyo, Japan. In Cancer Sci, 2007
Since FGFR1OP is plays a significant role in lung cancer growth and progression, it may be useful as a prognostic biomarker and as a therapeutic target for lung cancer.
Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization.
Holak et al., Martinsried, Germany. In J Mol Biol, 2006
a 1.6A resolution crystal structure of the N-terminal dimerization domain of FOP. The structure comprises an alpha-helical bundle composed of two antiparallel chains, each of them having five alpha-helices.
A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.
Nigg et al., Martinsried, Germany. In Mol Biol Cell, 2006
CAP350 interacts directly with FOP (FGFR1 oncogene partner) to form a centrosomal complex required for microtubule anchoring.
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