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Fibroblast growth factor receptor 1

FGFR1, fibroblast growth factor receptor 1
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Fibroblast Growth Factor 2, CAN, FGFR2, HAD, V1a
Papers using FGFR1 antibodies
Interaction of tissue transglutaminase with nuclear transport protein importin-α3
Kojima Soichi et al., In Molecular Cancer, 1998
... Mouse anti-Sp1 (IC6), rabbit anti-Sp1 (PEP2), anti-EGFR, anti-c-Met, anti-FGFR1 antibodies were bought from Santa Cruz Biotechnology (Santa Cruz, CA).
Localization of beta 1, beta 3, alpha 5, alpha v, and alpha IIb subunits of the integrin family in spreading erythroleukemia cells
Belkin Alexey M. et al., In The Journal of Cell Biology, 1989
... Rabbit polyclonal antibody against FXIIIa was from Calbiochem and antibody against FGF receptor FGFR-1 Flg (H-76) was from Santa Cruz Biotechnology.
Papers on FGFR1
FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice.
Hurley et al., Farmington, United States. In J Cell Biochem, Feb 2016
Since abnormal Wnt signaling was reported in Hyp mice we assessed whether Wnt signaling was impaired in HMWTg kidneys and the effect of blocking FGF receptor (FGFR) signaling.
Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study.
Stephens et al., Albany, United States. In Breast Cancer Res Treat, Feb 2016
Amplification of FGFR1 or ZNF703, located within the same amplicon, was found in 8 of 22 cases (36 %).
Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis.
Chiosea et al., Ottawa, Canada. In Head Neck Pathol, Feb 2016
A subset of PMTs harbours an FGFR1 translocation although this alteration has not been demonstrated in PMT involving a head and neck site.
Evidence Based Theory for Integrated Genome Regulation of Ontogeny - an Unprecedented Role of Nuclear FGFR1 Signaling.
Stachowiak et al., Buffalo, United States. In J Cell Physiol, Feb 2016
UNASSIGNED: Genetic experiments have positioned the fgfr1 gene at the top of the gene hierarchy that governs gastrulation, as well as the subsequent development of the major body axes, nervous system, muscles, and bones, by affecting downstream genes that control the cell cycle, pluripotency and differentiation, as well as microRNAs.
FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression.
Fuxe et al., Stockholm, Sweden. In Trends Neurosci, Jan 2016
The discovery of brain fibroblast growth factor receptor 1 (FGFR1)-5 hydroxytryptamine receptor 1A (5-HT1A) heteroreceptor complexes, and their enhancement of neuroplasticity, offers an integration of these hypotheses at the molecular level.
Altered FGF signalling in congenital craniofacial and skeletal disorders.
Wollnik et al., Göttingen, Germany. In Semin Cell Dev Biol, Jan 2016
In humans, four FGFRs are described, and, to date, mutations in FGFR1, FGFR2, and FGFR3 have been shown to underlie human developmental disorders.
Fibroblast Growth Factor Receptors: From the Oncogenic Pathway to Targeted Therapy.
Varella-Garcia et al., Aurora, United States. In Curr Mol Med, Dec 2015
DNA and RNA-based technologies have been used to detect these abnormalities, especially in FGFR1, FGFR2 and FGFR3 and tests have been developed for their detection, but no assay has been proved ideal for molecular diagnosis.
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2.
Baselga et al., Houston, United States. In J Clin Oncol, Nov 2015
RESULTS: Progression-free survival benefit with everolimus was maintained regardless of alteration status of PIK3CA, FGFR1, and CCND1 or the pathways of which they are components.
The genomic landscape of response to EGFR blockade in colorectal cancer.
Velculescu et al., Torino, Italy. In Nature, Nov 2015
In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy.
Whole genomes redefine the mutational landscape of pancreatic cancer.
Grimmond et al., Brisbane, Australia. In Nature, Mar 2015
A significant proportion harboured focal amplifications, many of which contained druggable oncogenes (ERBB2, MET, FGFR1, CDK6, PIK3R3 and PIK3CA), but at low individual patient prevalence.
Landscape of gene fusions in epithelial cancers: seq and ye shall find.
Chinnaiyan et al., Ann Arbor, United States. In Genome Med, 2014
Tumors with fusions involving therapeutically targetable genes such as ALK, RET, BRAF, RAF1, FGFR1-4, and NOTCH1-3 have immediate implications for precision medicine across tissue types.
The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data.
Liu et al., Nanjing, China. In Biomed Res Int, 2014
The prognostic factors of the fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer (NSCLC) remain controversial.
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.
Kieran et al., Montréal, Canada. In Nat Genet, 2014
Gain-of-function mutations in ACVR1 occur in tumors of the pons in conjunction with histone H3.1 p.Lys27Met substitution, whereas FGFR1 mutations or fusions occur in thalamic tumors associated with histone H3.3 p.Lys27Met substitution.
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.
Rafii et al., New York City, United States. In Cancer Cell, 2014
Here, we show that FGF4 produced by B cell lymphoma cells (LCs) through activating FGFR1 upregulates the Notch ligand Jagged1 (Jag1) on neighboring ECs.
Transforming fusions of FGFR and TACC genes in human glioblastoma.
Iavarone et al., New York City, United States. In Science, 2012
study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity
The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
Oess et al., Frankfurt am Main, Germany. In Embo J, 2012
NOSTRIN participates in FGF signal transduction and vascular development.
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.
Grose et al., London, United Kingdom. In J Cell Biol, 2012
FGFR1 localized to the nucleus specifically in invading cells in both clinical material and a three-dimensional model of breast cancer
Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1.
Kim et al., Sacramento, United States. In Febs Lett, 2012
proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs
FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms.
Knowles et al., Leeds, United Kingdom. In Plos One, 2011
FGFR1 activation in urothelial carcinoma cell lines promotes epithelial-mesenchymal transition via coordinated activation of multiple signalling pathways and by promoting activation of prostaglandin synthesis.
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