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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Fibroblast growth factor 21

FGF21, Fibroblast growth factor 21
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, ACID, HAD, fibrillin-1, CAN
Papers on FGF21
Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway.
Carriere et al., Toulouse, France. In Biochem J, Feb 2016
UNASSIGNED: The fibroblast growth factor-21 (FGF21), firstly described as a main fasting responsive molecule in the liver, has been shown to act as a true metabolic regulator in additional tissues including muscle and adipose tissues.
Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet.
Ross et al., Paraguay. In J Nutr, Feb 2016
BACKGROUND: Fibroblast growth factor 21 (FGF21) is a regulator of carbohydrate and lipid metabolism; however, the regulation of Fgf21 gene expression by diet remains incompletely understood.
Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles.
Lee et al., Suwŏn, South Korea. In Endocrine, Feb 2016
We investigated whether the levels and signalings of FGF21 changed in the skeletal muscle of type 2 diabetes mellitus (T2DM) patients, participants with impaired glucose tolerance (IGT), human skeletal muscle myotubes (HSMMs) under insulin-resistant conditions, and mice with diet-induced obesity (DIO).
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.
Dixit et al., New Haven, United States. In Proc Natl Acad Sci U S A, Feb 2016
Here we show that the prolongevity ketogenic hormone fibroblast growth factor 21 (FGF21), a member of the endocrine FGF subfamily, is expressed in thymic stromal cells along with FGF receptors and its obligate coreceptor, βKlotho.
Potential roles of fibroblast growth factor 21 in the brain.
Chattipakorn et al., Chiang Mai, Thailand. In Metab Brain Dis, Feb 2016
UNASSIGNED: Fibroblast growth factor 21 (FGF21) is an endocrine hormone, playing an important role in the regulation of metabolism.
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.
Moschetta et al., Bari, Italy. In Nat Rev Drug Discov, Jan 2016
The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting.
FGF21 Regulates Sweet and Alcohol Preference.
Kliewer et al., Cambridge, United States. In Cell Metab, Jan 2016
UNASSIGNED: Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis.
FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.
Potthoff et al., Copenhagen, Denmark. In Cell Metab, Jan 2016
Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.
Practical prospects for boosting hepatic production of the "pro-longevity" hormone FGF21.
McCarty, In Horm Mol Biol Clin Investig, Jan 2016
UNASSIGNED: Fibroblast growth factor-21 (FGF21), produced mainly in hepatocytes and adipocytes, promotes leanness, insulin sensitivity, and vascular health while down-regulating hepatic IGF-I production.
Understanding the Physiology of FGF21.
Maratos-Flier et al., Boston, United States. In Annu Rev Physiol, Dec 2015
UNASSIGNED: Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several organs and regulates energy homeostasis.
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wan et al., Dallas, United States. In Cell Metab, Dec 2015
Fibroblast growth factor 21 (FGF21) promotes insulin sensitivity but causes bone loss.
[Mechanisms of the role of fibroblast growth factor 21 in attenuating insulin resistance].
Li et al., In Yao Xue Xue Bao, Sep 2015
This study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on type 2 diabetic mice model and to provide mechanistic insights into its therapeutic effect.
The sum of all browning in FGF21 therapeutics.
Greenfield et al., Australia. In Cell Metab, Jul 2015
FGF21 mimetics are a promising therapeutic tool, believed to exert their anti-obesity effect partly through browning of white fat.
Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity.
Bartesaghi et al., Mölndal, Sweden. In Front Endocrinol (lausanne), 2014
In this review, we discuss three different drug classes [the thiazolidinedione (TZD) class of PPARγ agonists, β3-adrenergic receptor agonists, and fibroblast growth factor 21 (FGF21) analogs] that have been proposed to regulate BAT and beige recruitment or activation, or both, and which have been tested in both rodent and human.
Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders.
Li et al., San Francisco, United States. In Front Endocrinol (lausanne), 2014
FGF21 expression is induced under different disease conditions, such as type 2 diabetes, obesity, chronic kidney diseases, and cardiovascular diseases, and it has a broad spectrum of functions in regulating various metabolic parameters.
Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21.
Díez et al., Madrid, Spain. In Eur J Endocrinol, 2012
[review] FGF21 is a recently identified hormone with antihyperglycemic, antihyperlipidemic, and thermogenic properties; it stimulates glucose uptake in adipocytes via induction of glucose transporter-1.
Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate.
De Luca et al., Philadelphia, United States. In J Biol Chem, 2012
FGF21 may directly suppress growth plate chondrocyte proliferation and differentiation.
Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21.
Hillgartner et al., Morgantown, United States. In J Biol Chem, 2012
the enhanced enterohepatic flux of bile acids during HF-LC consumption leads to activation of hepatic FXR and FGF19 signaling activity and an increase in FGF21 gene expression and secretion.
Long-term high-fat diet links the regulation of the insulin-sensitizing fibroblast growth factor-21 and visfatin.
Li et al., Chongqing, China. In Cytokine, 2012
The aim of present study is to evaluate the effects of long-term high-fat diet on the regulation of the insulin-sensitizing fibroblast growth factor-21 (FGF-21) and visfatin in ApoE(-/-) mice.
Exercise increases serum fibroblast growth factor 21 (FGF21) levels.
Aguilar-Salinas et al., Mexico. In Plos One, 2011
Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positively with clinical parameters related to the adrenergic and lipolytic response to exercise
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