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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Fibroblast growth factor 14

FGF14, fibroblast growth factor 14, fibroblast growth factor 14 gene, SCA27, FHF4
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CACNA1A, FGF12, SCA10, Fibroblast Growth Factor 2
Papers on FGF14
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
Kiessling et al., Athens, Greece. In Stem Cells Dev, Feb 2016
High-level detection of CSF1R, ENG, IL23R, and IL3RA specifically on the 8C arrays suggests the embryo plays an active role in blocking immune rejection and is poised for trophectoderm development; robust detection of NRG1, GAB1, -2, GRB7, and FGF14(FHF4) indicates novel roles in early development in addition to their known roles in later development.
Effects of low level laser therapy on inflammatory and angiogenic gene expression during the process of bone healing: A microarray analysis.
Rennó et al., São Carlos, Brazil. In J Photochem Photobiol B, Jan 2016
Microarray analysis demonstrated that LLLT produced an up-regulation of the genes related to the inflammatory process (MMD, PTGIR, PTGS2, Ptger2, IL1, 1IL6, IL8, IL18) and the angiogenic genes (FGF14, FGF2, ANGPT2, ANGPT4 and PDGFD) at 36h and 3days, followed by the decrease of the gene expression on day 7. Immunohistochemical analysis revealed that the subjects that were treated presented a higher expression of COX-2 at 36h after surgery and an increased VEGF expression on days 3 and 7 after surgery.
Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus.
Laezza et al., Galveston, United States. In Mol Neurobiol, Jan 2016
Here, we provide evidence for a previously undescribed function of fibroblast growth factor 14 (FGF14), a brain disease-associated factor that controls neuronal excitability and synaptic plasticity, in regulating adult neurogenesis in the dentate gyrus (DG).
High-throughput alternative splicing detection using dually constrained correspondence analysis (DCCA).
Brutsche et al., Sankt Gallen, Switzerland. In J Biomed Inform, Dec 2015
Splicing candidates reveal a series of genes related to carcinogenesis (SFTPB), cell adhesion (STAB2, PCDH15, HABP2), tumor aggressiveness (ARNTL2), apoptosis, proliferation and differentiation (PDE4D, FLT3, IL1R2), cell invasion (ETV1), as well as tumor growth (OLFM4, FGF14), tumor necrosis (AFF3) or tumor suppression (TUSC3, CSMD1, RHOBTB2, SERPINB5), with indication of known alternative splicing in a majority of genes.
Role of long purine stretches in controlling the expression of genes associated with neurological disorders.
Rajeswari et al., New Delhi, India. In Gene, Dec 2015
Interactome analysis identified four PR-genes in signaling pathways whose dysregulation is correlated directly with pathogenesis: GRK5 and KLK6 in Alzheimer's disease; FGF14 in craniosynostosis, mental retardation and FLT1 in neuroferritinopathy.
Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance.
Nerbonne et al., Saint Louis, United States. In J Neurosci, May 2015
Mutations in FGF14, which encodes intracellular fibroblast growth factor 14 (iFGF14), have been linked to spinocerebellar ataxia (SCA27).
Split-luciferase complementation assay to detect channel-protein interactions in live cells.
Laezza et al., Galveston, United States. In Methods Mol Biol, 2014
As a response to the urgent need of developing rapid and albeit accurate technologies to survey ion channel molecular complexes, we describe a new application of the split-luciferase complementation assay to study the interaction of the voltage-gated Na + channel with the intracellular fibroblast growth factor 14 and its dynamic regulation in live cells.
Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
Laezza et al., Galveston, United States. In Plos One, 2014
Here, we applied LCA in live cells to assay 12 kinase pathways as regulators of the PPI complex formed by the voltage-gated sodium channel, Nav1.6, a transmembrane ion channel that elicits the action potential in neurons and mediates synaptic transmission, and its multivalent accessory protein, the fibroblast growth factor 14 (FGF14).
Spinocerebellar ataxia 28: a novel AFG3L2 mutation in a German family with young onset, slow progression and saccadic slowing.
Bürk et al., Lübeck, Germany. In Cerebellum Ataxias, 2014
METHODS: After excluding repeat expansions in the genes for SCA1-3, 6-8, 10, 12, and 17, Sanger sequencing of the coding regions of TTBK2 (SCA11), KCNC3 (SCA13), PRKCG (SCA14), FGF14 (SCA27) and AFG3L2 (SCA28) was performed.
Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27.
Laezza et al., Galveston, United States. In Front Cell Neurosci, 2014
Genetically inherited mutations in the fibroblast growth factor 14 (FGF14) gene lead to spinocerebellar ataxia type 27 (SCA27), an autosomal dominant disorder characterized by heterogeneous motor and cognitive impairments.
Roles of intracellular fibroblast growth factors in neural development and functions.
Li et al., Shanghai, China. In Sci China Life Sci, 2012
FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neurons.
Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.
Hennessey et al., Durham, United States. In Trends Cardiovasc Med, 2011
The four fibroblast growth factor homologous factors (FHFs; FGF11-FGF14) are intracellular proteins that bind and modulate voltage-gated sodium channels (VGSCs).
Autosomal dominant cerebellar ataxia type I: a review of the phenotypic and genotypic characteristics.
Wszolek et al., Johnson City, United States. In Orphanet J Rare Dis, 2010
To date, 21 subtypes have been identified: SCA1-SCA4, SCA8, SCA10, SCA12-SCA14, SCA15/16, SCA17-SCA23, SCA25, SCA27, SCA28 and dentatorubral pallidoluysian atrophy (DRPLA).
Autosomal dominant cerebellar ataxias: polyglutamine expansions and beyond.
Durr, Paris, France. In Lancet Neurol, 2010
All other SCAs are caused by either conventional mutations or large rearrangements in genes with different functions, including glutamate signalling (SCA5/SPTBN2) and calcium signalling (SCA15/16/ITPR1), channel function (SCA13/KCNC3, SCA14/PRKCG, SCA27/FGF14), tau regulation (SCA11/TTBK2), and mitochondrial activity (SCA28/AFG3L2) or RNA alteration (SCA31/BEAN-TK2).
FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.
Yamada et al., Saint Louis, United States. In Neurobiol Dis, 2009
results suggest that FGF14 is required for normal Nav1.6 expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 channels
Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.
D'Angelo et al., New York City, United States. In Neuron, 2007
Sodium channels in Fhf1-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state.
Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor.
Tan et al., In Am J Med Genet B Neuropsychiatr Genet, 2007
FGF14 mutations in Ataxia and childhood onset postural tremor.
Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14.
Ornitz et al., Saint Louis, United States. In Neurobiol Dis, 2007
these results suggest a role for FGF14 in certain spatial learning functions and synaptic plasticity
Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14.
Ornitz et al., Saint Louis, United States. In Mol Cell Neurosci, 2007
FGF14 in regulating synaptic plasticity via presynaptic mechanisms by affecting the mobilization, trafficking, or docking of synaptic vesicles to presynaptic active zones.
Spinocerebellar Ataxia Type 15
Storey, Seattle, United States. In Unknown Journal, 2006
DIAGNOSIS/TESTING: The diagnosis of SCA15 should be considered in individuals in whom the diagnoses of SCA5, SCA6, SCA8, SCA11, SCA12, SCA14, and SCA27 have been excluded by molecular genetic testing (if available) and who fulfill the clinical diagnostic criteria for SCA15.
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