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Fibroblast growth factor 12

FGF12, fibroblast growth factor homologous factor, FHF-1
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, FGF-2, FGF14, SCN5A
Papers on FGF12
Rare copy number variants implicated in posterior urethral valves.
Mills et al., Bethesda, United States. In Am J Med Genet A, Jan 2016
Other interesting CNVs, each detected in a single PUV case included: a deletion of PIK3R3 and TSPAN1, duplication/triplication in FGF12, duplication of FAT1-a gene essential for normal growth and development, a large deletion (>2 Mb) on chromosome 17q that involves TBX2 and TBX4, and large duplications (>1 Mb) on chromosomes 3q and 6q.
SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Mohler et al., Columbus, United States. In Proc Natl Acad Sci U S A, Nov 2015
Nav channels are essential for metazoan membrane depolarization, and Nav channel dysfunction is directly linked with epilepsy, ataxia, pain, arrhythmia, myotonia, and irritable bowel syndrome.
Exome sequencing identified FGF12 as a novel candidate gene for Kashin-Beck disease.
Guo et al., Xi'an, China. In Funct Integr Genomics, Sep 2015
We identified a novel 106T>C at the 3'UTR of the FGF12 gene, which has not been reported by now.
Exposure to aflatoxin B1 in utero is associated with DNA methylation in white blood cells of infants in The Gambia.
Routledge et al., Lyon, France. In Int J Epidemiol, Aug 2015
Aflatoxin-associated differential methylation was observed in growth factor genes such as FGF12 and IGF1, and immune-related genes such as CCL28, TLR2 and TGFBI.
Regulation of smooth muscle contractility by competing endogenous mRNAs in intracranial aneurysms.
Jiang et al., Beijing, China. In J Neuropathol Exp Neurol, May 2015
Using a multifaceted computational and experimental approach, we determined that depletion of competitive endogenous RNAs (ARHGEF12, FGF12, and ADCY5) enhanced factors that downregulate MYOCD, which induces the conversion of SMCs from differentiated contractile states into dedifferentiated phenotypes that exhibit enhanced proliferation, synthesis of new extracellular matrix, and organization of mural thrombi.
Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.
Laezza et al., Galveston, United States. In Mol Cell Proteomics, May 2015
Of the identified putative protein interactors, fibroblast growth factor 12 (FGF12), a member of the nonsecreted intracellular FGF family, exhibited 30-fold enrichment in Nav1.2 purifications compared with other identified proteins.
Differentially expressed genes in metastatic advanced Egyptian bladder cancer.
Abu-Taleb et al., Cairo, Egypt. In Asian Pac J Cancer Prev, 2014
PLCB2 was involved in 11 different pathways, MDM2 in 9 pathways, FZD4 in 5 pathways, p15 and FGF12 in 4 pathways, POLE2 in 3 pathways, and MCM4 and POLR2E in 2 pathways.
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis.
Kashuba et al., Moscow, Russia. In Dis Markers, 2014
Frequent methylation of the discovered loci was confirmed by bisulfite sequencing on selective sampling of genes: FGF12, GATA2, and LMCD1.
Genomic and epigenomic analyses of monozygotic twins discordant for congenital renal agenesis.
Chen et al., Beijing, China. In Am J Kidney Dis, 2014
KEGG analysis indicated the DMRs localized to 10 signaling pathways and 25 genes, including the mitogen-activated protein kinase pathway and 6 genes (FGF18, FGF12, PDGFRA, MAPK11, AMH, CTBP1) involved in organ development.
Cellular internalization of fibroblast growth factor-12 exerts radioprotective effects on intestinal radiation damage independently of FGFR signaling.
Imai et al., Chiba, Japan. In Int J Radiat Oncol Biol Phys, 2014
In contrast, FGF12 cannot activate any FGFRs.
FGF12 is a candidate Brugada syndrome locus.
Pitt et al., Durham, United States. In Heart Rhythm, 2013
OBJECTIVE: The goal of this study was to test whether FGF12 is a candidate BrS locus.
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
Pitt et al., Durham, United States. In Nat Commun, 2013
Here we report the crystal structures of two ternary complexes of a human NaV cytosolic C-terminal domain (CTD), a fibroblast growth factor homologous factor and Ca(2+)/calmodulin (Ca(2+)/CaM).
Polymorphisms in FGF12, VCL, CX43 and VAX1 in Brazilian patients with nonsyndromic cleft lip with or without cleft palate.
Coletta et al., Piracicaba, Brazil. In Bmc Med Genet, 2012
Previous association studies with populations from Europe and Asia have identified putative susceptibility markers for NSCL/P in fibroblast growth factor 12 (FGF12), vinculin (VCL), connexin 43 (CX43) and in a region close to the ventral anterior homeobox 1 (VAX1) gene.
Roles of intracellular fibroblast growth factors in neural development and functions.
Li et al., Shanghai, China. In Sci China Life Sci, 2012
FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neurons.
Identification of novel DNA methylation markers in colorectal cancer using MIRA-based microarrays.
Yang et al., Yinchuan, China. In Oncol Rep, 2012
PHOX2B, FGF12 and GAD2 genes are hypermethylated in colorectal neoplastic tissue
Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12.
Akashi et al., Chiba, Japan. In J Biol Chem, 2011
exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane
Involvement of intracellular expression of FGF12 in radiation-induced apoptosis in mast cells.
Meineke et al., München, Germany. In J Radiat Res (tokyo), 2008
These findings suggest that FGF12 intracellularly suppresses radiation-induced apoptosis in mast cells independently of IB2.
Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene-related peptide-positive nociceptive neurons in the murine dorsal root ganglia.
Fichard-Carroll et al., Montpellier, France. In J Comp Neurol, 2008
results argue strongly against the possibility that FHF1 has a modulatory effect on the Na(v)1.9 sodium channel isoform in cRet+/IB4+ neurons, but FHF1 could play a role in a distinct subset of TrkA+/CGRP+ nociceptors.
Biophysical characterization of fibroblast growth factor homologous factor-1b (FHF-1b): sodium dodecyl sulfate promotes two state folding.
Jagannadham et al., Guwāhāti, India. In Protein Pept Lett, 2007
Data describe the biophysical characterization and folding of fibroblast growth factor homologous factor-1b (FHF-1b) in comparison with acidic fibroblast growth factor (FGF-1), and show that FHF-1 is significantly more stable than FGF-1.
Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins.
Kass et al., Lausanne, Switzerland. In Trends Cardiovasc Med, 2005
ankyrin proteins, fibroblast growth factor homologous factor 1B, calmodulin, Nedd4-like ubiquitin-protein ligases, and syntrophin proteins.
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