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Fibroblast growth factor 5

FGF-5, Fibroblast Growth Factor 5
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Fibroblast Growth Factor 2, CAN, HAIR, keratinocyte growth factor, HAD
Papers on FGF-5
Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats.
Chen et al., China. In Gene, Feb 2016
To determine the relationship between fibroblast growth factor 5 (FGF5) and FGF5-short (FGF5s) in dermal papilla cells of cashmere goat primary and secondary hair follicles.
Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway.
Pospelov et al., Saint Petersburg, Russia. In Cell Death Dis, Dec 2015
mTOR activation is accompanied by a decrease of pluripotent gene expression Oct-4, Nanog, Sox2 and by an augmentation of fgf5 gene expression - a marker of post-implantation epiblast.
A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster.
Hashizume et al., Abashiri, Japan. In Mamm Genome, Nov 2015
FGF5, one of the hair cycle regulators, has a role in inducing catagen, and that mutation causes abnormal hair length in both sexes in humans, mice, dogs, and cats.
Cloning, molecular characterization, and expression pattern of FGF5 in Cashmere goat (Capra hircus).
Wang et al., Hohhot, China. In Genet Mol Res, 2014
Fibroblast growth factor 5 (FGF5) is a secreted signaling protein that belongs to the FGF family, and was found to be associated with hair growth in humans and other animals.
Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5.
He et al., China. In Genet Mol Res, 2014
Fibroblast growth factor 5 (FGF5) has been previously reported to be involved in the initiation of the catagen phase of hair growth.
Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians.
Mi et al., Jinan, China. In Metabolism, 2013
A meta-analysis was performed to assess the associations of the most published polymorphisms, including CSK rs1378942, CYP17A1 rs11191548, MTHFR rs17367504, and FGF5 rs16998073 polymorphisms with hypertension.
[Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice].
Koniukhov et al., In Ontogenez, 2012
Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice
Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
Lin et al., Shanghai, China. In J Hypertens, 2011
Variants in or near FGF5, CYP17A1 and MTHFR contributed to variation in BP and hypertension risk. Effect sizes of these three loci tended to be larger in Chinese than in white Europeans
Fluctuations of BMP signaling pathway during hair cycles in skin of mice with mutant genes we, wal and Fgf5(go).
Konyukhov et al., In J Dermatol Sci, 2010
Fluctuations of BMP2 signaling pathway during hair cycles in skin with mutant genes we, wal and Fgf5(go).
Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair.
Yagami et al., Tsukuba, Japan. In Exp Anim, 2010
A deletion of a 9.3-kb region in the Fgf5 gene showed insertion of a 498-bp early transposon element long terminal repeat. Results show that long hair mutation of moja/moja mice is caused by Fgf5 disruption mediated by retrotransposon insertion.
Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese.
Zhu et al., Shanghai, China. In Clin Chim Acta, 2010
variation in FGF5 and ZNF652 gene upstream regions with altered susceptibility to hypertension in Han Chinese
Coat variation in the domestic dog is governed by variants in three genes.
Ostrander et al., Bethesda, United States. In Science, 2009
Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States.
Genome-wide association study identifies eight loci associated with blood pressure.
Munroe et al., Boston, United States. In Nat Genet, 2009
We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes.
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.
Studer et al., New York City, United States. In Nat Biotechnol, 2009
Temporal fate analysis reveals the appearance of a transient FGF5(+) epiblast-like stage followed by PAX6(+) neural cells competent to form rosettes.
Immune recognition of a human renal cancer antigen through post-translational protein splicing.
Yang et al., Bethesda, United States. In Nature, 2004
C2 CTLs, cloned from human CTLs infiltrating a renal cell carcinoma, kill cancer cells overexpressing fibroblast growth factor-5 (FGF-5).
Fibroblast growth factors and their receptors in the central nervous system.
von Bohlen und Halbach et al., Heidelberg, Germany. In Cell Tissue Res, 2003
In the CNS, FGFs are widely expressed; FGF-2 is predominantly synthesized by astrocytes, whereas other FGF family members, e.g., FGF-5, FGF-8, and FGF-9, are primarily synthesized by neurons.
[Hair growth effect of minoxidil].
Otomo, Saitama, Japan. In Nihon Yakurigaku Zasshi, 2002
On the other hand, negative factors, like FGF-5, thrombospondin, or still unknown ones, terminate the anagen phase.
Attenuation of FGF signalling in mouse beta-cells leads to diabetes.
Edlund et al., Umeå, Sweden. In Nature, 2001
Here we show that the FGF receptors (FGFRs) 1 and 2, together with the ligands FGF1, FGF2, FGF4, FGF5, FGF7 and FGF10, are expressed in adult mouse beta-cells, indicating that FGF signalling may have a role in differentiated beta-cells.
Technology evaluation: gene therapy (FGF-5), Vical.
Ward et al., Los Angeles, United States. In Curr Opin Mol Ther, 1999
Vical has obtained preclinical data in animal models showing that a gene for a potent growth factor, FGF-5, can be delivered and expressed in coronary arteries stimulating the formation of new blood vessels.
Development of the neuromuscular junction: genetic analysis in mice.
Zhou et al., Saint Louis, United States. In J Physiol Paris, 1998
Here, we review our studies on neuromuscular development in mutant mice lacking agrin alpha CGRP, rapsyn, MuSK, dystrophin, dystrobrevin, utrophin, laminin alpha 5, laminin beta 2, collagen alpha 3 (IV), the acetylcholine receptor epsilon subunit, the collagenous tail of acetylcholinesterase, fibroblast growth factor-5, the neural cell adhesion molecule, and tenascin-C.
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