GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Leucine zipper, putative tumor suppressor 1
FEZ1, LZTS1, F37
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009] (from
NCBI)
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Top mentioned proteins:
DISC1, ACID, CAN, Nudel, V1a
Papers using
FEZ1
antibodies
Two binding partners cooperate to activate the molecular motor Kinesin-1
Supplier
In The Journal of Cell Biology, 2005
... A full-length clone of FEZ1 was isolated from a Marathon-Ready human brain cDNA library (CLONTECH Laboratories, Inc.) and inserted ...
Papers on
FEZ1
Striatal Reward Activity and Antipsychotic-Associated Weight Change in Patients With Schizophrenia Undergoing Initial Treatment.
New
Copenhagen, Denmark. In Jama Psychiatry, Feb 2016
After 6 weeks, weight gain was associated with an increase in mean (SD) reward activity in the same region during treatment (0.28 [0.74]; F37,1 = 4.48; P = .04).
The tumor-suppressor gene LZTS1 suppresses hepatocellular carcinoma proliferation by impairing PI3K/Akt pathway.
New
Shanghai, China. In Biomed Pharmacother, Dec 2015
BACKGROUND: To study the role of LZTS1 in hepatocellular carcinoma (HCC) proliferation and the molecular mechanism involved.
PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.
New
Maebashi, Japan. In J Neurosci, Nov 2015
PSD-Zip70 (Lzts1/FEZ1) is a postsynaptic density (PSD) protein predominantly expressed in the frontal cortex, olfactory bulb, striatum, and hippocampus.
[miR-135b promotes the invasion and metastasis of hepatocellular carcinoma cells].
New
Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Oct 2015
Western blotting and dual-luciferase report system analysis showed that multiple key components in the Hippo pathway, including large tumor suppressor homolog 2 (LATS2), beta-transducin repeats-containing proteins (β-TrCP), N-myc downstream-regulated gene 2 (NDR2) as well as leucine zipper tumor suppressor gene 1 (LZTS1) were targeted by miR-135b.
Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.
New
Karāchi, Pakistan. In Mol Cell Biochem, Jul 2015
Up-regulation of CASP7(Caspase7) and LZTS1 (leucine zipper, putative tumor suppressor 1) and down-regulation of DNMT1(DNA (cytosine-5-)-methyltransferase 1) was noted in treated cells.
Molecular basis of major psychiatric diseases such as schizophrenia and depression.
Review
New
Ōsaka, Japan. In Anat Sci Int, Jun 2015
DISC1 is involved in neural development directly via adhesion molecules or via its binding partners of DISC1 such as elongation protein ζ-1 (FEZ1), DISC1-binding zinc-finger protein (DBZ) and kendrin.
HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.
Chicago, United States. In Nat Commun, 2014
Here we show that human immunodeficiency virus type 1 (HIV-1) associates with the kinesin-1 adaptor protein, Fasiculation and Elongation Factor zeta 1 (FEZ1).
An S188V mutation alters substrate specificity of non-stereospecific α-haloalkanoic acid dehalogenase E (DehE).
Kuantan, Malaysia. In Plos One, 2014
MD simulations showed that residues W34, F37, and S188 of DehE were crucial for substrate binding.
MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma.
Milwaukee, United States. In Plos One, 2014
In functional studies, inhibition of miR-135b by specific anti-miR oligonucleotides resulted in upregulation of its target gene LZTS1 mRNA and protein levels and led to decreased cell motility and invasion of both primary and metastatic cSCC cell lines.
Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family.
Gent, Belgium. In Dis Markers, 2014
Subsequent whole exome sequencing revealed the presence of a unique missense variant in the LZTS1 gene, located within the candidate region.
The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development.
GeneRIF
Umeå, Sweden. In Dev Dyn, 2012
Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons.
Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.
GeneRIF
Göttingen, Germany. In Proc Natl Acad Sci U S A, 2012
FEZ1 operates as a kinesin adaptor for the transport of Stx, with cargo loading and unloading being regulated by protein kinases.
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
GeneRIF
Baltimore, United States. In Neuron, 2011
Fezzeta-1 interacts with disrupted in schizophrenia (DISC)1 to synergistically regulate dendritic growth of newborn neurons in the adult mouse hippocampus.
Down-regulation of leucine zipper putative tumor suppressor 1 is associated with poor prognosis, increased cell motility and invasion, and epithelial-to-mesenchymal transition characteristics in human breast carcinoma.
GeneRIF
Tianjin, China. In Hum Pathol, 2011
Lower levels of leucine zipper putative tumor suppressor 1 correlated with high histologic grade, lymph node metastasis, and poor prognosis.
Four mood stabilizers commonly induce FEZ1 expression in human astrocytes.
GeneRIF
Sendai, Japan. In Bipolar Disord, 2011
The data of this study suggested that FEZ1 may play important roles in human astrocytes, and that mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes.
Functions of fasciculation and elongation protein zeta-1 (FEZ1) in the brain.
Review
GeneRIF
Nagaoka, Japan. In Scientificworldjournal, 2009
Studies indicate that suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Review
Hastings, United Kingdom. In Schizophr Bull, 2009
Other viral or bacterial components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB, NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by Apolipoprotein E (APOE).
"JIP"ing along the axon: the complex roles of JIPs in axonal transport.
Review
Bengaluru, India. In Bioessays, 2008
In mammalian cell culture, JIP1 is necessary and, together with UNC-76/FEZ1, sufficient for activating Kinesin-I.2
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
Impact
GeneRIF
Columbus, United States. In Cancer Cell, 2007
Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice.
[Recent research on the JC virus].
Review
Sapporo, Japan. In Brain Nerve, 2007
Second, a yeast two-hybrid screen of a human brain cDNA library demonstrated that the fasciculation and elongation protein zeta 1 (FEZ1) and the heterochromatin protein 1alpha (HP1alpha) are proteins that interacted with JCV agnoprotein (Agno).
