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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, fibrillin-1, C-reactive protein
Papers on FEV
Generation of functional human serotonergic neurons from fibroblasts.
Gage et al., Los Angeles, United States. In Mol Psychiatry, Jan 2016
FEV, GATA2 and LMX1B in combination with ASCL1 and NGN2 directly and efficiently generated serotonergic neurons from human fibroblasts.
Combined value of apparent diffusion coefficient-standardized uptake value max in evaluation of post-treated locally advanced rectal cancer.
Sironi et al., Milano, Italy. In World J Radiol, Jan 2016
All patients underwent a whole body (18)FDG positron emission tomography (PET)/computed tomography (CT) scan and a pelvic magnetic resonance (MR) examination including diffusion weighted (DW) imaging for staging (PET1, RM1) and after completion (6.6 wk) of neoadjuvant treatment (PET2, RM2).
Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH.
Antonescu et al., Kayseri, Turkey. In Genes Chromosomes Cancer, Jan 2016
Among the 85 SBRCTs tested, seven (8.2%) cases harbored FUS gene rearrangements; six fused to ERG and one with FEV.
Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma.
Imyanitov et al., Saint Petersburg, Russia. In Gastrointest Tumors, Sep 2015
However, polymerase chain reaction testing for ES-specific rearrangements (EWSR1/FLI1, EWSR1/ERG, EWSR1/ETV1, EWSR1/ETV4, EWS/FEV) failed to confirm the ES origin of the neoplastic tissue.
[Ewing/PNET sarcoma family of tumors: towards a new paradigm?].
Ranchère-Vince et al., Lyon, France. In Ann Pathol, 2015
Besides the rearrangements between the FET family of genes (EWS or FUS) and the wide ETS family of genes (FLI1, ERG, FEV, ETV…), new partner genes are gradually identified: cases with EWS-non ETS partners are extremely rare, but there are more important groups which are CIC-DUX4 and BCOR-CCNB3 translocation-positive sarcomas.
Role of Serum Interleukin 6, Albumin and C-Reactive Protein in COPD Patients.
Zaerin et al., Eşfahān, Iran. In Tanaffos, 2014
There was no significant difference among the three groups in this regard (P=0.099).There was a significant inverse relationship between serum levels of IL-6 and FEV 1 (r=-0.341,
In vivo treatment sensitivity testing with positron emission tomography/computed tomography after one cycle of chemotherapy for Hodgkin lymphoma.
Coleman et al., Copenhagen, Denmark. In J Clin Oncol, 2014
This prospective study aimed to assess the prognostic value of PET after one cycle of chemotherapy in HL and to assess the dynamics of FDG uptake after one cycle (PET1) and after two cycles (PET2).
The potential for aclidinium bromide, a new anticholinergic, in the management of chronic obstructive pulmonary disease.
Milot et al., Québec, Canada. In Ther Adv Respir Dis, 2012
In two phase III studies (ACCORD I and ATTAIN), both aclidinium 200 µg and 400 µg BID provided statistically significant improvements in trough forced expiratory volume in 1 second (FEV(1)) and other related lung function measurements.
Probing the diversity of serotonin neurons.
Lillesaar et al., Paris, France. In Philos Trans R Soc Lond B Biol Sci, 2012
In both species, PET1 plays a major role in the acquisition and maintenance of 5-HT identity in the hindbrain, although some 5-HT neurons do not require PET1 for their differentiation, indicating the existence of several transcriptional routes to become serotoninergic.
Roflumilast--a phosphodiesterase-4 inhibitor licensed for add-on therapy in severe COPD.
Kullak-Ublick et al., Zürich, Switzerland. In Swiss Med Wkly, 2011
Roflumilast is a selective phosphodiesterase 4 inhibitor which has been licensed in the European Union since 2010 and in Switzerland since November 2011 as an add-on treatment for patients with chronic obstructive pulmonary disease (COPD) in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages 3 and 4 (FEV(1) <50% predicted after bronchodilatation) and frequent exacerbations despite correctly-dosed therapy with a long-acting bronchodilator.
Monosodium glutamate avoidance for chronic asthma in adults and children.
Dong et al., Chengdu, China. In Cochrane Database Syst Rev, 2011
They reported the number of subjects who had a maximum fall in forced expiratory volume in the first second (FEV(1)) greater than 15% or 200 mL after MSG or the control challenge.
A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.
VX08-770-102 Study Group et al., Seattle, United States. In N Engl J Med, 2011
The primary end point was the estimated mean change from baseline through week 24 in the percent of predicted forced expiratory volume in 1 second (FEV(1)).
Lebrikizumab treatment in adults with asthma.
Matthews et al., Los Angeles, United States. In N Engl J Med, 2011
The primary efficacy outcome was the relative change in prebronchodilator forced expiratory volume in 1 second (FEV(1)) from baseline to week 12.
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
Tamari et al., Yokohama, Japan. In Nat Genet, 2011
We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07 × 10(-23)), which is close to rs2070600, a SNP previously reported for association with FEV(1)/FVC in genome-wide association studies for lung function.
A transient placental source of serotonin for the fetal forebrain.
Levitt et al., Los Angeles, United States. In Nature, 2011
To examine putative central and peripheral sources of embryonic brain 5-HT, we used Pet1(-/-) (also called Fev) mice in which most dorsal raphe neurons lack 5-HT.
Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo.
Albert et al., Ottawa, Canada. In J Neurochem, 2011
The data of this study indicated that, in addition to transcriptional regulation by Pet-1 in raphe neurons, 5-HT1A receptor expression is regulated indirectly by alterations in 5-HT neurotransmission in a region-specific manner
A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.
Gaspar et al., Paris, France. In J Neurosci, 2011
Pet1-dependent and Pet1-resistant 5-serotonin (5-HT) neurons target different brain centers that might delineate the anatomical basis for a dual serotonergic control on stress responses.
Pet-1 is required across different stages of life to regulate serotonergic function.
Deneris et al., Cleveland, United States. In Nat Neurosci, 2010
This study indicated that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.
The expression of the transcription factor FEV in adult human brain and its association with affective disorders.
Schmitt et al., Würzburg, Germany. In J Neural Transm, 2010
our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders
Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks.
Nattie et al., United States. In Am J Physiol Regul Integr Comp Physiol, 2010
Pet-1(-/-) neonates are probably not hypoxic from respiratory dysfunction until P14-15; neither apnea-related hypoxia nor greater hypopnea contribute to the enhanced bradycardias of Pet-1 and there may be enhanced temperature reflex in hyperthermia
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