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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


fetuin-A, AHSG, alpha-2-HS-glycoprotein
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, AGE, Insulin, HAD, fibrillin-1
Papers on fetuin-A
Urinary Peptide Analysis Differentiates Pancreatic Cancer From Chronic Pancreatitis.
Lankisch et al., Hannover, Germany. In Pancreas, Feb 2016
Fetuin-A was the most prominent peptide marker source for PCA as verified by immunoassay and IHC.
Association of serum fetuin-A levels with the risk of albuminuria in middle-aged and elderly Chinese.
Xu et al., Shanghai, China. In J Clin Endocrinol Metab, Feb 2016
CONTEXT: Fetuin-A is an important hepatokine associated with many cardiometabolic abnormities.
Very low protein diet enhances inflammation, malnutrition, and vascular calcification in uremic rats.
Ooboshi et al., Fukuoka, Japan. In Life Sci, Feb 2016
After 6weeks, body weight, urinary biochemistry (creatinine and phosphate), serum biochemical parameters (urea, creatinine, fibroblast growth factor 23, albumin, and fetuin-A), systemic inflammatory markers (serum tumor necrosis factor-alpha and urinary 8-hydroxy-2'-deoxyguanosine), calcium content in the aorta, and serum calcium-phosphate precipitates were evaluated.
The relationship between malnutrition subgroups and volume parameters in pre-dialysis patients.
Ütük et al., İstanbul, Turkey. In Saudi J Kidney Dis Transpl, Jan 2016
Serum inflammation markers [high-sensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 and tumor necrosis factor-alfa] and nutrition parameters (albumin, pre-albumin, transferrin, fetuin-A, insulin like growth factor-1 and insulin-like growth factor-binding protein-3)] were measured in all the patients.
From infancy to aging: Biological and behavioral modifiers of Fetuin-A.
Teran-Garcia et al., Urbana, United States. In Biochimie, Jan 2016
UNASSIGNED: Fetuin-A is a multifunctional protein which inhibits ectopic calcification and insulin receptor phosphorylation.
Koçak-Toker et al., İstanbul, Turkey. In Arch Physiol Biochem, Jan 2016
UNASSIGNED: Effects of curcumin (turmeric) and capsaicin (red pepper) on hepatic fat accumulation and fetuin-A expression in rats fed high fat diet (HFD) is aimed to be investigated.
Evaluation of Arterial Stiffness in Patients with Behçet's Disease by Using Noninvasive Radiological Methods such as Intima-Media Thickness of the Carotid, Ankle-Brachial Pressure Index, Coronary Artery Calcium Scoring, and Their Relation to Serum Fetuin-A Levels: A Case-Control Study.
Saklamaz et al., İzmir, Turkey. In Ann Dermatol, Dec 2015
OBJECTIVE: We performed this study to evaluate arterial stiffness in patients with BD by using noninvasive radiological methods such as carotid artery intima-media thickness (CIMT), ankle-brachial pressure index (ABPI), coronary artery calcium score (CACaS), and their relation to serum fetuin-A levels, which was recently found to be important in vascular calcification.
Pathophysiology of Vascular Calcification.
Moe et al., Indianapolis, United States. In Curr Osteoporos Rep, Dec 2015
The imbalance of promoters (such as hyperphosphatemia and hypercalcemia) and inhibitors (e.g., fetuin-A) is critical in the development of vascular calcification.
Emerging Liver-Kidney Interactions in Nonalcoholic Fatty Liver Disease.
Gambino et al., Torino, Italy. In Trends Mol Med, Oct 2015
NAFLD affects renal injury through lipoprotein dysmetabolism and altered secretion of the hepatokines fibroblast growth factor-21, fetuin-A, insulin-like growth factor-1, and syndecan-1.
Biomarkers of insulin sensitivity and insulin resistance: Past, present and future.
Sweeney et al., Seoul, South Korea. In Crit Rev Clin Lab Sci, 2014
This review discusses potential biomarkers including adiponectin, RBP4, chemerin, A-FABP, FGF21, fetuin-A, myostatin, IL-6, and irisin, all of which may play significant roles in determining insulin sensitivity.
The role of fetuin-A in mineral trafficking and deposition.
Holt et al., Melbourne, Australia. In Bonekey Rep, 2014
In the past decade, through in vitro, in vivo and clinical observation studies, we have come to appreciate the importance of fetuin-A (Fet-A), a circulating glycoprotein, in preventing ectopic calcium phosphate mineralisation.
Serum and tissue biomarkers in aortic stenosis.
Cokkinos et al., Athens, Greece. In Glob Cardiol Sci Pract, 2014
We prospectively studied the following serum BMs in 60 patients with CAVS and compared them to 20 healthy controls, free from any cardiac disease: Matrix metalloproteinases (MMP) 2 and 9 and tissue inhibitor of metalloproteinase 1 (TIMP1), which regulate collagen turnover, inflammatory factors, i.e. tumor necrosis factor a (TNFa), interleukin 2 (IL2), transforming growth factor β1 (TGF-β1) which regulates fibrosis, fetuin-A (fet-A), osteopontin (OPN), osteoprotegerin (OPG), sclerostin (SOST), and relaxin-2 (RL2) which positively or negatively regulate calcification.
Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.
Jahnen-Dechent et al., Aachen, Germany. In Circ Res, 2012
Fetuin-A-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A.
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance.
Bhattacharya et al., India. In Nat Med, 2012
Here we show that fetuin-A (FetA) could be this endogenous ligand and that it has a crucial role in regulating insulin sensitivity via Tlr4 signaling in mice.
Serum Fetuin-A and Pentraxin3 in hemodialysis and renal transplant patients.
Meimand et al., Tabrīz, Iran. In Clin Biochem, 2012
Data show that serum Fetuin-A concentration was significantly higher in the hemodialysis (HD) compared to renal transplant (RT) group.
Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance.
Chang et al., Tainan City, Taiwan. In Endocrinology, 2012
ER stress induced by high glucose and palmitate increases the expression of fetuin-A and further contributes to the development of insulin resistance
Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study.
Djousse et al., San Diego, United States. In Circulation, 2012
Higher fetuin-A is associated with incident diabetes mellitus in older persons regardless of sex, race, or prevalent cardiovascular disease status.
The association of fetuin-A with cardiovascular disease mortality in older community-dwelling adults: the Rancho Bernardo study.
Ix et al., San Diego, United States. In J Am Coll Cardiol, 2012
Low fetuin-A levels predicted greater risk for CVD mortality in older adults without diabetes, but were associated with reduced risk of CVD death in those with diabetes
Fetuin-A and incident diabetes mellitus in older persons.
Health ABC Study et al., San Diego, United States. In Jama, 2008
Among well-functioning older persons, serum fetuin-A is associated with incident diabetes mellitus, independent of other markers of insulin resistance.
Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study.
Floege et al., Aachen, Germany. In Lancet, 2003
Fetuin-A (alpha2-Heremans Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response.
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