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Membrane-spanning 4-domains, subfamily A, member 2

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: IgE, HAD, MAST, CD20, CAN
Papers on FCER1B
Interactions between Ibrutinib and Anti-CD20 Antibodies: Competing Effects on the Outcome of Combination Therapy.
Wiestner et al., Bethesda, United States. In Clin Cancer Res, Feb 2016
An NF-κB binding site in the promoter of MS4A1 (encoding CD20) and downregulation of CD20 by NF-κB inhibitors support a direct transcriptional effect.
The MS4A family: counting past 1, 2 and 3.
Hulett et al., Melbourne, Australia. In Immunol Cell Biol, Jan 2016
The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4).
Genomic Profile of Fatigued Men Receiving Localized Radiation Therapy.
Saligan et al., Cleveland, United States. In Biol Res Nurs, Dec 2015
Membrane-spanning four domains, subfamily A, member (MS4A1) was the most differentially expressed gene and was associated with fatigue at treatment end point (r = -.46,
Four-locus gene interaction between IL13, IL4, FCER1B, and ADRB2 for asthma in Chinese Han children.
Ji et al., Shanghai, China. In Pediatr Pulmonol, Dec 2015
RATIONALE: IL13, IL4, IL4RA, FCER1B, and ADRB2 are important inflammatory genes associated with immunoglobulin E levels.
Interferon at the crossroads of allergy and viral infections.
Farrar et al., Dallas, United States. In J Leukoc Biol, Aug 2015
These findings support a model, whereby allergic and antiviral responses are able to cross-regulate each other, as IgER cross-linking of pDCs prevents IFN-α/β production in response to viral infection.
Identification of IL13 C1923T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius.
Fang et al., Shanghai, China. In Pediatr Allergy Immunol Pulmonol, Jul 2015
Results: No statistically significant differences (p>0.05) were found between the experimental and control group in genotype distribution among nine of the loci (MS4A2 E237G, MS4A2 C-109T, ADRB2 R16G, IL4RA Q551R, IL4RA I75V, IL4 C-590T, IL13 A2044G, IL13 C-1112T, and CHI3L1 C-131G).
MS4A Cluster in Alzheimer's Disease.
Tan et al., Qingdao, China. In Mol Neurobiol, Jun 2015
Besides, although the MS4A family members are poorly characterized, an important role in immunity has already been identified for several members of this cluster (such as MS4A1, MS4A2, and MS4A4B), indicating the possible involvement of MS4A gene cluster in AD pathogenesis.
Multifactor-dimensionality reduction reveals interaction of important gene variants involved in allergy.
Ramos et al., Manila, Philippines. In Int J Immunogenet, Jun 2015
SNPs genotyped include the IL4 -590C>T (rs2243250), FCER1B E237G (rs569108), CD14 -159C>T (rs2569190), IL4RA Q551R (rs1801275) and ADRB2 R16G (rs1042713).
Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets.
Lai et al., Taipei, Taiwan. In World J Gastroenterol, 2015
A 7-gene model of CPEB4, EIF2S3, MGC20553, MS4A1, ANXA3, TNFAIP6 and IL2RB was pairwise selected, which showed the best results in logistic regression analysis (H-L P = 1.000,
The expression of B & T cell activation markers in children's tonsils following live attenuated influenza vaccine.
Brokstad et al., Bergen, Norway. In Hum Vaccin Immunother, 2014
Meanwhile at 6-7 days post vaccination, 9 genes were significantly up-regulated, including RIPK2, TGFB1, MICB, SOCS1, IL2RA, MS4A1, PTPRC, IL2 and IL8.
B Cell Markers of Operational Tolerance Can Discriminate Acute Kidney Allograft Rejection From Stable Graft Function.
Claas et al., Leiden, Netherlands. In Transplantation, 2014
We also determined expression levels of the B cell-related genes, MS4A1, TCL1A, and CD79B, in PBMCs and isolated B cells.
Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.
Golab et al., Warsaw, Poland. In Mabs, 2013
A transcriptional profiling of tumor cells incubated with SFKs inhibitors revealed strong downregulation of MS4A1 gene encoding CD20 antigen.
Impact of capsaicin on mast cell inflammation.
Pandolfi et al., Thessaloníki, Greece. In Int J Immunopathol Pharmacol, 2013
Mast cells possess high-affinity receptors for IgE (FcERI) and the cross-linking of these receptors is essential to trigger the secretion of granules containing arachidonic acid metabolism (such as prostaglandin (PG) D2, leukotriene (LT) B4, and LTC4), histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases.
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.
Metcalfe et al., Bethesda, United States. In Immunity, 2013
Human linkage analyses have implicated the MS4A2-containing gene locus (encoding FcεRIβ) as a candidate for allergy susceptibility.
(99m)Tc-Labeled rituximab, a chimeric murine/human anti-CD20 monoclonal antibody
Chopra, Bethesda, United States. In Unknown Journal, 2012
Rituximab is a chimeric murine/human monoclonal antibody (mAb) that targets the CD20 antigen (also known as membrane-spanning 4-domains, subfamily A, member 1; or MS4A1), which is expressed on 95% of the transformed B-cells that participate in the pathogenesis of non-Hodgkin lymphomas (NHL; diffused large-B cell, low-grade, or the follicular types), a hematological malignancy, and autoimmune diseases such as rheumatoid arthritis (RA), granulomatosis with polyangiitis (Wegener's granulomatosis), and microscopic polyangiitis.
Demethylation of the FCER1G promoter leads to FcεRI overexpression on monocytes of patients with atopic dermatitis.
Lu et al., Changsha, China. In Allergy, 2012
Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis.
Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk.
Weidinger et al., Liège, Belgium. In Allergy, 2010
No associations with total and specific IgE levels as well as allergic sensitization were seen for FCER1B and FCER1G
Characterization of the methylation patterns of MS4A2 in atopic cases and controls.
Duffy et al., Brisbane, Australia. In Allergy, 2010
Methylation levels at the AluSp repeat analysed in MS4A2 were inconsistent with classical imprinting mechanisms and did not associate with atopy status
Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma.
Kim et al., Seoul, South Korea. In Eur J Pediatr, 2009
Polymorphisms in the Fc epsilon R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways in asthmatic patients.
A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.
ISAAC Phase 2 Study Group et al., Ulm, Germany. In Clin Exp Allergy, 2009
Significant associations of single nucleotide polymorphisms with wheeze in the past year were detected in only four genes (IL4R, TLR4, MS4A2, TLR9). Variants in IL4R and TLR4 were also related to allergen-specific IgE, but not for MS4A2 and TLR9.
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